ID C4RJ69_MICS3 Unreviewed; 201 AA. AC C4RJ69; DT 07-JUL-2009, integrated into UniProtKB/TrEMBL. DT 07-JUL-2009, sequence version 1. DT 24-JAN-2024, entry version 40. DE SubName: Full=Dihydrofolate reductase {ECO:0000313|EMBL:EEP70594.1}; GN ORFNames=MCAG_00921 {ECO:0000313|EMBL:EEP70594.1}; OS Micromonospora sp. (strain ATCC 39149 / NRRL 15099 / SCC 1413). OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales; OC Micromonosporaceae; Micromonospora. OX NCBI_TaxID=219305 {ECO:0000313|EMBL:EEP70594.1, ECO:0000313|Proteomes:UP000010307}; RN [1] {ECO:0000313|Proteomes:UP000010307} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 39149 / NRRL 15099 / SCC 1413 RC {ECO:0000313|Proteomes:UP000010307}; RG The Broad Institute Genome Sequencing Platform; RG Broad Institute Microbial Sequencing Center; RA Fischbach M., Godfrey P., Ward D., Young S., Kodira C.D., Zeng Q., RA Koehrsen M., Alvarado L., Berlin A.M., Borenstein D., Chen Z., Engels R., RA Freedman E., Gellesch M., Goldberg J., Griggs A., Gujja S., Heiman D.I., RA Hepburn T.A., Howarth C., Jen D., Larson L., Lewis B., Mehta T., Park D., RA Pearson M., Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C., RA Sykes S.N., Walk T., White J., Yandava C., Straight P., Clardy J., Hung D., RA Kolter R., Mekalanos J., Walker S., Walsh C.T., Wieland-Brown L.C., RA Galagan J., Nusbaum C., Birren B.; RT "The genome sequence of Micromonospora carbonacea var. africana strain ATCC RT 39149."; RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; GG657738; EEP70594.1; -; Genomic_DNA. DR AlphaFoldDB; C4RJ69; -. DR STRING; 219305.MCAG_00921; -. DR eggNOG; COG0262; Bacteria. DR HOGENOM; CLU_043966_1_2_11; -. DR OMA; PGYRNSG; -. DR Proteomes; UP000010307; Unassembled WGS sequence. DR GO; GO:0008703; F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity; IEA:InterPro. DR GO; GO:0009231; P:riboflavin biosynthetic process; IEA:InterPro. DR Gene3D; 3.40.430.10; Dihydrofolate Reductase, subunit A; 1. DR InterPro; IPR024072; DHFR-like_dom_sf. DR InterPro; IPR002734; RibDG_C. DR PANTHER; PTHR38011:SF11; 2,5-DIAMINO-6-(5-PHOSPHO-D-RIBOSYLAMINO)PYRIMIDIN-4(3H)-ONE REDUCTASE; 1. DR PANTHER; PTHR38011; DIHYDROFOLATE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G06820); 1. DR Pfam; PF01872; RibD_C; 1. DR SUPFAM; SSF53597; Dihydrofolate reductase-like; 1. PE 4: Predicted; KW Reference proteome {ECO:0000313|Proteomes:UP000010307}. FT DOMAIN 12..193 FT /note="Bacterial bifunctional deaminase-reductase C- FT terminal" FT /evidence="ECO:0000259|Pfam:PF01872" SQ SEQUENCE 201 AA; 22480 MW; A38F2E6207DBF564 CRC64; MHLKPTKELP VRTLIATAFV SLDGVIEAPG GEPGYRNSGW TFKDIEFDEA AYEIKSREQD EATAMLLGRV SYQAFSPVWP DMTAEFPGYN AMPKYVVSTT LQEKDLVSNW GEISILRSLD DVAALKKTEG GPIIIHGSAT LNRELADARL IDRYHLLVFP VLLSAGKRLF SDTDRDKQNL KLIESESYAN GIQKLVYDVI R //