ID   C4A0B6_BRAFL            Unreviewed;      1336 AA.
AC   C4A0B6;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   26-FEB-2020, entry version 84.
DE   RecName: Full=Tyrosine-protein kinase receptor {ECO:0000256|RuleBase:RU000312};
DE            EC=2.7.10.1 {ECO:0000256|RuleBase:RU000312};
GN   ORFNames=BRAFLDRAFT_128184 {ECO:0000313|EMBL:EEN41775.1};
OS   Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC   Eukaryota; Metazoa; Chordata; Cephalochordata; Branchiostomidae;
OC   Branchiostoma.
OX   NCBI_TaxID=7739 {ECO:0000313|Proteomes:UP000001554};
RN   [1] {ECO:0000313|EMBL:EEN41775.1, ECO:0000313|Proteomes:UP000001554}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN41775.1,
RC   ECO:0000313|Proteomes:UP000001554};
RC   TISSUE=Testes {ECO:0000313|EMBL:EEN41775.1};
RX   PubMed=18563158; DOI=10.1038/nature06967;
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA   Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA   Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA   Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA   Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA   Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA   Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA   Satoh N., Rokhsar D.S.;
RT   "The amphioxus genome and the evolution of the chordate karyotype.";
RL   Nature 453:1064-1071(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC         [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC         COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC         ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC         Evidence={ECO:0000256|RuleBase:RU000312,
CC         ECO:0000256|SAAS:SAAS01168082};
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC       kinase family. Insulin receptor subfamily.
CC       {ECO:0000256|RuleBase:RU000312}.
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DR   EMBL; GG666796; EEN41775.1; -; Genomic_DNA.
DR   RefSeq; XP_002585764.1; XM_002585718.1.
DR   STRING; 7739.XP_002585764.1; -.
DR   GeneID; 7254882; -.
DR   KEGG; bfo:BRAFLDRAFT_128184; -.
DR   eggNOG; KOG4258; Eukaryota.
DR   eggNOG; COG0515; LUCA.
DR   InParanoid; C4A0B6; -.
DR   KO; K04527; -.
DR   OMA; KFRGYAF; -.
DR   OrthoDB; 223327at2759; -.
DR   Proteomes; UP000001554; Partially assembled WGS sequence.
DR   GO; GO:0030424; C:axon; IBA:GO_Central.
DR   GO; GO:0005899; C:insulin receptor complex; IBA:GO_Central.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0043560; F:insulin receptor substrate binding; IBA:GO_Central.
DR   GO; GO:0005009; F:insulin-activated receptor activity; IBA:GO_Central.
DR   GO; GO:0043548; F:phosphatidylinositol 3-kinase binding; IEA:InterPro.
DR   GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IBA:GO_Central.
DR   GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR   GO; GO:0042593; P:glucose homeostasis; IBA:GO_Central.
DR   GO; GO:0007275; P:multicellular organism development; IBA:GO_Central.
DR   GO; GO:0033674; P:positive regulation of kinase activity; IBA:GO_Central.
DR   GO; GO:0043410; P:positive regulation of MAPK cascade; IBA:GO_Central.
DR   GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; IBA:GO_Central.
DR   GO; GO:0051897; P:positive regulation of protein kinase B signaling; IBA:GO_Central.
DR   GO; GO:0046777; P:protein autophosphorylation; IEA:InterPro.
DR   GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
DR   CDD; cd00063; FN3; 3.
DR   CDD; cd00064; FU; 1.
DR   Gene3D; 2.60.40.10; -; 2.
DR   Gene3D; 3.80.20.20; -; 2.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR006211; Furin-like_Cys-rich_dom.
DR   InterPro; IPR006212; Furin_repeat.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR000494; Rcpt_L-dom.
DR   InterPro; IPR036941; Rcpt_L-dom_sf.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   InterPro; IPR020635; Tyr_kinase_cat_dom.
DR   InterPro; IPR016246; Tyr_kinase_insulin-like_rcpt.
DR   InterPro; IPR002011; Tyr_kinase_rcpt_2_CS.
DR   Pfam; PF00041; fn3; 2.
DR   Pfam; PF00757; Furin-like; 1.
DR   Pfam; PF07714; Pkinase_Tyr; 1.
DR   Pfam; PF01030; Recep_L_domain; 2.
DR   PIRSF; PIRSF000620; Insulin_receptor; 2.
DR   PRINTS; PR00109; TYRKINASE.
DR   SMART; SM00060; FN3; 3.
DR   SMART; SM00261; FU; 1.
DR   SMART; SM00219; TyrKc; 1.
DR   SUPFAM; SSF49265; SSF49265; 2.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   SUPFAM; SSF57184; SSF57184; 1.
DR   PROSITE; PS50853; FN3; 3.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR   PROSITE; PS00239; RECEPTOR_TYR_KIN_II; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PIRSR:PIRSR000620-2,
KW   ECO:0000256|SAAS:SAAS00600564}; Kinase {ECO:0000256|SAAS:SAAS00601152};
KW   Membrane {ECO:0000256|SAAS:SAAS00602125, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR000620-2,
KW   ECO:0000256|SAAS:SAAS00600689};
KW   Phosphoprotein {ECO:0000256|RuleBase:RU000312};
KW   Receptor {ECO:0000256|RuleBase:RU000312, ECO:0000256|SAAS:SAAS00600436};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001554};
KW   Repeat {ECO:0000256|SAAS:SAAS00786331}; Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000256|SAAS:SAAS00601608};
KW   Transmembrane {ECO:0000256|RuleBase:RU000312,
KW   ECO:0000256|SAAS:SAAS00600943, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00602683,
KW   ECO:0000256|SAM:Phobius};
KW   Tyrosine-protein kinase {ECO:0000256|SAAS:SAAS00582553}.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           30..1336
FT                   /note="Tyrosine-protein kinase receptor"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002935171"
FT   TRANSMEM        902..925
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          440..553
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          557..647
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          781..885
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          967..1256
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   NP_BIND         1048..1054
FT                   /note="ATP"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000620-2"
FT   NP_BIND         1125..1126
FT                   /note="ATP"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000620-2"
FT   REGION          704..723
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1064..1093
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1289..1336
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1074..1088
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1292..1336
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        1121
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000620-1"
FT   BINDING         977
FT                   /note="ATP"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000620-2"
FT   BINDING         1001
FT                   /note="ATP"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000620-2"
FT   BINDING         1139
FT                   /note="ATP"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000620-2"
SQ   SEQUENCE   1336 AA;  151287 MW;  763A2E02244BDA7B CRC64;
     MRVVDKMAGL MWAALTLVIG LGLLVPSNGE EYICDSMDIR NRVTNLRQLE NCTVIEGYLQ
     ILLIDFAEEQ DYRGLSFPNL VEITDYFLLY RVRGLTNLSE LFPNLAVIRG TNLFFNYALV
     VFEMLDMQKI GLYSLQNITR GSVRIEKNPN LCYLDTIDWS FIAESGYRNN FIVDNRDEEE
     CGYCPKRCRN ENPVVLQDLC WAEEHCQKVC PESCLGNCLD GSSGCCHENC IGGCDGPTER
     DCVACKYFVH NGECLIQCPP DTYQYKDRRC ITEDECPNTT NAVWKLHHRK CIPECPSGYT
     TDVNNPRLCT ECEGQCPKYN IITELEENLG LIEEVGHYVA IVRSYALVTL DFLRSLKRIR
     GIQKENGYAF YVLDNRNLEK LFEWDRTDLT IDEGKLFFHF NPKLCRHVIL TMVEKVGLPP
     DTITDTDIST LTNGDQAQCS FSRLEIEEIN TRKDMIILRW SEFTPPDPRD LLSYTVSYRE
     TEEQGIDEYD GQDACGNTEW KEFDVSPDQR AHIITGLKPW TQYALLVKTY TKAGAREGSG
     AKSDIVYART DADKPTHPQD VVVYSNSSNT LIITWKPPNR PNGNVTHYIV RYKRQLEEED
     SMEHREYCIG GLKPHRPTQG LEDIVNNEEE PNNGTIGDGT CCECPKSEDE IRIEEEEAAF
     QQEFENFLHN NVYHKRENET RAGRRRRELP VTARPFYSNQ TVNVTLPSTN TTAPPTPTPN
     PNPQLETTVW NEHMVVLTGL RHFSEYIIEV IACNADVINV GCSGSAVELA RTQADDSADN
     IPGNITVDVG VDVETKVKMA KLYWPKPYQP NSMVVLYNVE YKKLGADGNY EQPQQKCVES
     YKLMEQQGYT ISNLVAGNYS VRVQATSFAG NGSWSNYVTF YVEEEDTSPA NQDPQQQVPV
     SLMIGMGVGF SLLVLLAVVF AFWYCTKKRF GDKQMPNGVL YASVNPEYMS SADVYVPDEW
     EVPREKITLI RELGQGSFGM VYEGEAKDLV KDEPMVSVAV KTVNESASIR ERIEFLNEAS
     VMKTFNCHHV VKLMGVVSKG QPTLVVMELM ALGDLKNYLR RHRPEEDAGL SDSPASNEAK
     NSPFAENDND PPPTFKDIIQ MAGEIADGMS YLAAKKFVHR DLACRNCMVA QDRTVKIGDF
     GMTRDIYETD YYRKGGKGLL PVRWMSPESL KDGVFTSQSD VWSYGVVLWE MATLASQPYQ
     GKSNEEVLKF VIDGGMLEKP EGCPNKLYDL MKLCWQYRQS MRPTFLEIVE ILSPELQAHF
     AEVSFYHSLD NHGREPLEMD DVALDSGADT ETEMYPSGSE FSSTPSPPSE TPYSHMNGSH
     PQNGSMNLRI PKSTLC
//