ID C4A0B6_BRAFL Unreviewed; 1336 AA. AC C4A0B6; DT 28-JUL-2009, integrated into UniProtKB/TrEMBL. DT 28-JUL-2009, sequence version 1. DT 16-JAN-2019, entry version 78. DE RecName: Full=Tyrosine-protein kinase receptor {ECO:0000256|RuleBase:RU000312}; DE EC=2.7.10.1 {ECO:0000256|RuleBase:RU000312}; GN ORFNames=BRAFLDRAFT_128184 {ECO:0000313|EMBL:EEN41775.1}; OS Branchiostoma floridae (Florida lancelet) (Amphioxus). OC Eukaryota; Metazoa; Chordata; Cephalochordata; Branchiostomidae; OC Branchiostoma. OX NCBI_TaxID=7739 {ECO:0000313|Proteomes:UP000001554}; RN [1] {ECO:0000313|EMBL:EEN41775.1, ECO:0000313|Proteomes:UP000001554} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN41775.1, RC ECO:0000313|Proteomes:UP000001554}; RC TISSUE=Testes {ECO:0000313|EMBL:EEN41775.1}; RX PubMed=18563158; DOI=10.1038/nature06967; RG US DOE Joint Genome Institute (JGI-PGF); RA Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U., RA Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K., RA Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., RA Gibson-Brown J.J., Grigoriev I.V., Horton A.C., de Jong P.J., RA Jurka J., Kapitonov V.V., Kohara Y., Kuroki Y., Lindquist E., RA Lucas S., Osoegawa K., Pennacchio L.A., Salamov A.A., Satou Y., RA Sauka-Spengler T., Schmutz J., Shin-I T., Toyoda A., RA Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H., RA Satoh N., Rokhsar D.S.; RT "The amphioxus genome and the evolution of the chordate karyotype."; RL Nature 453:1064-1071(2008). CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L- CC tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, CC Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; CC EC=2.7.10.1; Evidence={ECO:0000256|RuleBase:RU000312, CC ECO:0000256|SAAS:SAAS01124082}; CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein CC kinase family. Insulin receptor subfamily. CC {ECO:0000256|RuleBase:RU000312}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; GG666796; EEN41775.1; -; Genomic_DNA. DR RefSeq; XP_002585764.1; XM_002585718.1. DR UniGene; Bfl.791; -. DR STRING; 7739.JGI128184; -. DR GeneID; 7254882; -. DR KEGG; bfo:BRAFLDRAFT_128184; -. DR eggNOG; KOG4258; Eukaryota. DR eggNOG; COG0515; LUCA. DR InParanoid; C4A0B6; -. DR KO; K04527; -. DR OMA; KFRGYAF; -. DR OrthoDB; 223327at2759; -. DR Proteomes; UP000001554; Partially assembled WGS sequence. DR GO; GO:0030424; C:axon; IBA:GO_Central. DR GO; GO:0005899; C:insulin receptor complex; IBA:GO_Central. DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central. DR GO; GO:0043235; C:receptor complex; IBA:GO_Central. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0043560; F:insulin receptor substrate binding; IBA:GO_Central. DR GO; GO:0005009; F:insulin-activated receptor activity; IBA:GO_Central. DR GO; GO:0043548; F:phosphatidylinositol 3-kinase binding; IEA:InterPro. DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IBA:GO_Central. DR GO; GO:0048856; P:anatomical structure development; IBA:GO_Central. DR GO; GO:0042593; P:glucose homeostasis; IBA:GO_Central. DR GO; GO:0043410; P:positive regulation of MAPK cascade; IBA:GO_Central. DR GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; IBA:GO_Central. DR GO; GO:0051897; P:positive regulation of protein kinase B signaling; IBA:GO_Central. DR GO; GO:0046777; P:protein autophosphorylation; IEA:InterPro. DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central. DR CDD; cd00063; FN3; 3. DR CDD; cd00064; FU; 1. DR Gene3D; 2.60.40.10; -; 2. DR Gene3D; 3.80.20.20; -; 2. DR InterPro; IPR003961; FN3_dom. DR InterPro; IPR036116; FN3_sf. DR InterPro; IPR006211; Furin-like_Cys-rich_dom. DR InterPro; IPR006212; Furin_repeat. DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR011009; Kinase-like_dom_sf. DR InterPro; IPR000719; Prot_kinase_dom. DR InterPro; IPR017441; Protein_kinase_ATP_BS. DR InterPro; IPR000494; Rcpt_L-dom. DR InterPro; IPR036941; Rcpt_L-dom_sf. DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom. DR InterPro; IPR008266; Tyr_kinase_AS. DR InterPro; IPR020635; Tyr_kinase_cat_dom. DR InterPro; IPR016246; Tyr_kinase_insulin-like_rcpt. DR InterPro; IPR002011; Tyr_kinase_rcpt_2_CS. DR Pfam; PF00041; fn3; 2. DR Pfam; PF00757; Furin-like; 1. DR Pfam; PF07714; Pkinase_Tyr; 1. DR Pfam; PF01030; Recep_L_domain; 2. DR PIRSF; PIRSF000620; Insulin_receptor; 2. DR PRINTS; PR00109; TYRKINASE. DR SMART; SM00060; FN3; 3. DR SMART; SM00261; FU; 1. DR SMART; SM00219; TyrKc; 1. DR SUPFAM; SSF49265; SSF49265; 2. DR SUPFAM; SSF56112; SSF56112; 1. DR SUPFAM; SSF57184; SSF57184; 1. DR PROSITE; PS50853; FN3; 3. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1. DR PROSITE; PS00239; RECEPTOR_TYR_KIN_II; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|PIRSR:PIRSR000620-2, KW ECO:0000256|SAAS:SAAS00708816}; KW Complete proteome {ECO:0000313|Proteomes:UP000001554}; KW Kinase {ECO:0000256|SAAS:SAAS00708717}; KW Membrane {ECO:0000256|SAAS:SAAS00602125, ECO:0000256|SAM:Phobius}; KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR000620-2, KW ECO:0000256|SAAS:SAAS00708656}; KW Phosphoprotein {ECO:0000256|RuleBase:RU000312}; KW Receptor {ECO:0000256|RuleBase:RU000312, KW ECO:0000256|SAAS:SAAS00600436}; KW Reference proteome {ECO:0000313|Proteomes:UP000001554}; KW Repeat {ECO:0000256|SAAS:SAAS00786331}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transferase {ECO:0000256|SAAS:SAAS00708727}; KW Transmembrane {ECO:0000256|RuleBase:RU000312, KW ECO:0000256|SAAS:SAAS00600943, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00602683, KW ECO:0000256|SAM:Phobius}; KW Tyrosine-protein kinase {ECO:0000256|SAAS:SAAS00582553}. FT SIGNAL 1 29 {ECO:0000256|SAM:SignalP}. FT CHAIN 30 1336 Tyrosine-protein kinase receptor. FT {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002935171. FT TRANSMEM 902 925 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 440 553 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 557 647 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 781 885 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 967 1256 Protein kinase. {ECO:0000259|PROSITE: FT PS50011}. FT NP_BIND 1048 1054 ATP. {ECO:0000256|PIRSR:PIRSR000620-2}. FT NP_BIND 1125 1126 ATP. {ECO:0000256|PIRSR:PIRSR000620-2}. FT ACT_SITE 1121 1121 Proton acceptor. {ECO:0000256|PIRSR: FT PIRSR000620-1}. FT BINDING 977 977 ATP. {ECO:0000256|PIRSR:PIRSR000620-2}. FT BINDING 1001 1001 ATP. {ECO:0000256|PIRSR:PIRSR000620-2}. FT BINDING 1139 1139 ATP. {ECO:0000256|PIRSR:PIRSR000620-2}. SQ SEQUENCE 1336 AA; 151287 MW; 763A2E02244BDA7B CRC64; MRVVDKMAGL MWAALTLVIG LGLLVPSNGE EYICDSMDIR NRVTNLRQLE NCTVIEGYLQ ILLIDFAEEQ DYRGLSFPNL VEITDYFLLY RVRGLTNLSE LFPNLAVIRG TNLFFNYALV VFEMLDMQKI GLYSLQNITR GSVRIEKNPN LCYLDTIDWS FIAESGYRNN FIVDNRDEEE CGYCPKRCRN ENPVVLQDLC WAEEHCQKVC PESCLGNCLD GSSGCCHENC IGGCDGPTER DCVACKYFVH NGECLIQCPP DTYQYKDRRC ITEDECPNTT NAVWKLHHRK CIPECPSGYT TDVNNPRLCT ECEGQCPKYN IITELEENLG LIEEVGHYVA IVRSYALVTL DFLRSLKRIR GIQKENGYAF YVLDNRNLEK LFEWDRTDLT IDEGKLFFHF NPKLCRHVIL TMVEKVGLPP DTITDTDIST LTNGDQAQCS FSRLEIEEIN TRKDMIILRW SEFTPPDPRD LLSYTVSYRE TEEQGIDEYD GQDACGNTEW KEFDVSPDQR AHIITGLKPW TQYALLVKTY TKAGAREGSG AKSDIVYART DADKPTHPQD VVVYSNSSNT LIITWKPPNR PNGNVTHYIV RYKRQLEEED SMEHREYCIG GLKPHRPTQG LEDIVNNEEE PNNGTIGDGT CCECPKSEDE IRIEEEEAAF QQEFENFLHN NVYHKRENET RAGRRRRELP VTARPFYSNQ TVNVTLPSTN TTAPPTPTPN PNPQLETTVW NEHMVVLTGL RHFSEYIIEV IACNADVINV GCSGSAVELA RTQADDSADN IPGNITVDVG VDVETKVKMA KLYWPKPYQP NSMVVLYNVE YKKLGADGNY EQPQQKCVES YKLMEQQGYT ISNLVAGNYS VRVQATSFAG NGSWSNYVTF YVEEEDTSPA NQDPQQQVPV SLMIGMGVGF SLLVLLAVVF AFWYCTKKRF GDKQMPNGVL YASVNPEYMS SADVYVPDEW EVPREKITLI RELGQGSFGM VYEGEAKDLV KDEPMVSVAV KTVNESASIR ERIEFLNEAS VMKTFNCHHV VKLMGVVSKG QPTLVVMELM ALGDLKNYLR RHRPEEDAGL SDSPASNEAK NSPFAENDND PPPTFKDIIQ MAGEIADGMS YLAAKKFVHR DLACRNCMVA QDRTVKIGDF GMTRDIYETD YYRKGGKGLL PVRWMSPESL KDGVFTSQSD VWSYGVVLWE MATLASQPYQ GKSNEEVLKF VIDGGMLEKP EGCPNKLYDL MKLCWQYRQS MRPTFLEIVE ILSPELQAHF AEVSFYHSLD NHGREPLEMD DVALDSGADT ETEMYPSGSE FSSTPSPPSE TPYSHMNGSH PQNGSMNLRI PKSTLC //