ID   C4A0B6_BRAFL            Unreviewed;      1336 AA.
AC   C4A0B6;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   28-FEB-2018, entry version 73.
DE   RecName: Full=Tyrosine-protein kinase receptor {ECO:0000256|RuleBase:RU000312};
DE            EC=2.7.10.1 {ECO:0000256|RuleBase:RU000312};
GN   ORFNames=BRAFLDRAFT_128184 {ECO:0000313|EMBL:EEN41775.1};
OS   Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC   Eukaryota; Metazoa; Chordata; Cephalochordata; Branchiostomidae;
OC   Branchiostoma.
OX   NCBI_TaxID=7739 {ECO:0000313|Proteomes:UP000001554};
RN   [1] {ECO:0000313|EMBL:EEN41775.1, ECO:0000313|Proteomes:UP000001554}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN41775.1,
RC   ECO:0000313|Proteomes:UP000001554};
RC   TISSUE=Testes {ECO:0000313|EMBL:EEN41775.1};
RX   PubMed=18563158; DOI=10.1038/nature06967;
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA   Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA   Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J.,
RA   Gibson-Brown J.J., Grigoriev I.V., Horton A.C., de Jong P.J.,
RA   Jurka J., Kapitonov V.V., Kohara Y., Kuroki Y., Lindquist E.,
RA   Lucas S., Osoegawa K., Pennacchio L.A., Salamov A.A., Satou Y.,
RA   Sauka-Spengler T., Schmutz J., Shin-I T., Toyoda A.,
RA   Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA   Satoh N., Rokhsar D.S.;
RT   "The amphioxus genome and the evolution of the chordate karyotype.";
RL   Nature 453:1064-1071(2008).
CC   -!- CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a
CC       [protein]-L-tyrosine phosphate. {ECO:0000256|RuleBase:RU000312,
CC       ECO:0000256|SAAS:SAAS00701269}.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC       kinase family. Insulin receptor subfamily.
CC       {ECO:0000256|RuleBase:RU000312}.
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DR   EMBL; GG666796; EEN41775.1; -; Genomic_DNA.
DR   RefSeq; XP_002585764.1; XM_002585718.1.
DR   UniGene; Bfl.791; -.
DR   STRING; 7739.JGI128184; -.
DR   GeneID; 7254882; -.
DR   KEGG; bfo:BRAFLDRAFT_128184; -.
DR   eggNOG; KOG4258; Eukaryota.
DR   eggNOG; COG0515; LUCA.
DR   InParanoid; C4A0B6; -.
DR   KO; K04527; -.
DR   OMA; FARTMPH; -.
DR   Proteomes; UP000001554; Partially assembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0043560; F:insulin receptor substrate binding; IEA:InterPro.
DR   GO; GO:0043548; F:phosphatidylinositol 3-kinase binding; IEA:InterPro.
DR   GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046777; P:protein autophosphorylation; IEA:InterPro.
DR   GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro.
DR   CDD; cd00063; FN3; 3.
DR   Gene3D; 2.60.40.10; -; 2.
DR   Gene3D; 3.80.20.20; -; 2.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR006211; Furin-like_Cys-rich_dom.
DR   InterPro; IPR006212; Furin_repeat.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR000494; Rcpt_L-dom.
DR   InterPro; IPR036941; Rcpt_L-dom_sf.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   InterPro; IPR020635; Tyr_kinase_cat_dom.
DR   InterPro; IPR016246; Tyr_kinase_insulin-like_rcpt.
DR   InterPro; IPR002011; Tyr_kinase_rcpt_2_CS.
DR   Pfam; PF00041; fn3; 2.
DR   Pfam; PF00757; Furin-like; 1.
DR   Pfam; PF07714; Pkinase_Tyr; 1.
DR   Pfam; PF01030; Recep_L_domain; 2.
DR   PIRSF; PIRSF000620; Insulin_receptor; 2.
DR   PRINTS; PR00109; TYRKINASE.
DR   SMART; SM00060; FN3; 3.
DR   SMART; SM00261; FU; 1.
DR   SMART; SM00219; TyrKc; 1.
DR   SUPFAM; SSF49265; SSF49265; 2.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   SUPFAM; SSF57184; SSF57184; 1.
DR   PROSITE; PS50853; FN3; 3.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR   PROSITE; PS00239; RECEPTOR_TYR_KIN_II; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00708816};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001554};
KW   Kinase {ECO:0000256|SAAS:SAAS00708717};
KW   Membrane {ECO:0000256|SAAS:SAAS00602125, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00708656};
KW   Phosphoprotein {ECO:0000256|RuleBase:RU000312};
KW   Receptor {ECO:0000256|RuleBase:RU000312,
KW   ECO:0000256|SAAS:SAAS00600436};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001554};
KW   Repeat {ECO:0000256|SAAS:SAAS00786331};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000256|SAAS:SAAS00708727};
KW   Transmembrane {ECO:0000256|RuleBase:RU000312,
KW   ECO:0000256|SAAS:SAAS00600943, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00602683,
KW   ECO:0000256|SAM:Phobius};
KW   Tyrosine-protein kinase {ECO:0000256|SAAS:SAAS00582553}.
FT   SIGNAL        1     29       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        30   1336       Tyrosine-protein kinase receptor.
FT                                {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002935171.
FT   TRANSMEM    902    925       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      440    553       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      557    647       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      781    885       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      967   1256       Protein kinase. {ECO:0000259|PROSITE:
FT                                PS50011}.
FT   ACT_SITE   1121   1121       Proton acceptor. {ECO:0000256|PIRSR:
FT                                PIRSR000620-1}.
SQ   SEQUENCE   1336 AA;  151287 MW;  763A2E02244BDA7B CRC64;
     MRVVDKMAGL MWAALTLVIG LGLLVPSNGE EYICDSMDIR NRVTNLRQLE NCTVIEGYLQ
     ILLIDFAEEQ DYRGLSFPNL VEITDYFLLY RVRGLTNLSE LFPNLAVIRG TNLFFNYALV
     VFEMLDMQKI GLYSLQNITR GSVRIEKNPN LCYLDTIDWS FIAESGYRNN FIVDNRDEEE
     CGYCPKRCRN ENPVVLQDLC WAEEHCQKVC PESCLGNCLD GSSGCCHENC IGGCDGPTER
     DCVACKYFVH NGECLIQCPP DTYQYKDRRC ITEDECPNTT NAVWKLHHRK CIPECPSGYT
     TDVNNPRLCT ECEGQCPKYN IITELEENLG LIEEVGHYVA IVRSYALVTL DFLRSLKRIR
     GIQKENGYAF YVLDNRNLEK LFEWDRTDLT IDEGKLFFHF NPKLCRHVIL TMVEKVGLPP
     DTITDTDIST LTNGDQAQCS FSRLEIEEIN TRKDMIILRW SEFTPPDPRD LLSYTVSYRE
     TEEQGIDEYD GQDACGNTEW KEFDVSPDQR AHIITGLKPW TQYALLVKTY TKAGAREGSG
     AKSDIVYART DADKPTHPQD VVVYSNSSNT LIITWKPPNR PNGNVTHYIV RYKRQLEEED
     SMEHREYCIG GLKPHRPTQG LEDIVNNEEE PNNGTIGDGT CCECPKSEDE IRIEEEEAAF
     QQEFENFLHN NVYHKRENET RAGRRRRELP VTARPFYSNQ TVNVTLPSTN TTAPPTPTPN
     PNPQLETTVW NEHMVVLTGL RHFSEYIIEV IACNADVINV GCSGSAVELA RTQADDSADN
     IPGNITVDVG VDVETKVKMA KLYWPKPYQP NSMVVLYNVE YKKLGADGNY EQPQQKCVES
     YKLMEQQGYT ISNLVAGNYS VRVQATSFAG NGSWSNYVTF YVEEEDTSPA NQDPQQQVPV
     SLMIGMGVGF SLLVLLAVVF AFWYCTKKRF GDKQMPNGVL YASVNPEYMS SADVYVPDEW
     EVPREKITLI RELGQGSFGM VYEGEAKDLV KDEPMVSVAV KTVNESASIR ERIEFLNEAS
     VMKTFNCHHV VKLMGVVSKG QPTLVVMELM ALGDLKNYLR RHRPEEDAGL SDSPASNEAK
     NSPFAENDND PPPTFKDIIQ MAGEIADGMS YLAAKKFVHR DLACRNCMVA QDRTVKIGDF
     GMTRDIYETD YYRKGGKGLL PVRWMSPESL KDGVFTSQSD VWSYGVVLWE MATLASQPYQ
     GKSNEEVLKF VIDGGMLEKP EGCPNKLYDL MKLCWQYRQS MRPTFLEIVE ILSPELQAHF
     AEVSFYHSLD NHGREPLEMD DVALDSGADT ETEMYPSGSE FSSTPSPPSE TPYSHMNGSH
     PQNGSMNLRI PKSTLC
//