ID C4A0B6_BRAFL Unreviewed; 1336 AA. AC C4A0B6; DT 28-JUL-2009, integrated into UniProtKB/TrEMBL. DT 28-JUL-2009, sequence version 1. DT 24-NOV-2009, entry version 6. DE RecName: Full=Tyrosine-protein kinase receptor; DE EC=2.7.10.1; GN ORFNames=BRAFLDRAFT_128184; OS Branchiostoma floridae (Florida lancelet) (Amphioxus). OC Eukaryota; Metazoa; Chordata; Cephalochordata; Branchiostomidae; OC Branchiostoma. OX NCBI_TaxID=7739; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=S238N-H82; TISSUE=Testes; RX PubMed=18563158; DOI=10.1038/nature06967; RA Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U., RA Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K., RA Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., RA Gibson-Brown J.J., Grigoriev I.V., Horton A.C., de Jong P.J., RA Jurka J., Kapitonov V.V., Kohara Y., Kuroki Y., Lindquist E., RA Lucas S., Osoegawa K., Pennacchio L.A., Salamov A.A., Satou Y., RA Sauka-Spengler T., Schmutz J., Shin-I T., Toyoda A., RA Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H., RA Satoh N., Rokhsar D.S.; RT "The amphioxus genome and the evolution of the chordate karyotype."; RL Nature 453:1064-1071(2008). CC -!- CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a CC [protein]-L-tyrosine phosphate. CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein CC kinase family. CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein CC kinase family. Insulin receptor subfamily. CC -!- SIMILARITY: Contains 1 protein kinase domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; GG666796; EEN41775.1; -; Genomic_DNA. DR RefSeq; XP_002585764.1; -. DR GeneID; 7254882; -. DR InterPro; IPR000494; EGF_rcpt_L. DR InterPro; IPR008957; Fibronectin_typ-III-like_fold. DR InterPro; IPR003961; FN_III. DR InterPro; IPR006211; Furin-like. DR InterPro; IPR006212; Furin_repeat. DR InterPro; IPR009030; Growth_fac_rcpt. DR InterPro; IPR011009; Kinase-like_dom. DR InterPro; IPR000719; Prot_kinase_cat_dom. DR InterPro; IPR017441; Protein_kinase_ATP_BS. DR InterPro; IPR016246; Tyr_kinase_insulin-like_rcpt. DR InterPro; IPR020714; Tyr_kinase_insulin_GF_rcpt. DR InterPro; IPR020685; Tyr_prot_kinase. DR InterPro; IPR008266; Tyr_prot_kinase_AS. DR InterPro; IPR001245; Tyr_prot_kinase_cat_dom. DR InterPro; IPR002011; Tyr_prot_kinase_rcpt_2_CS. DR InterPro; IPR020635; Tyr_prot_kinase_subgr_cat_dom. DR Gene3D; G3DSA:2.60.40.30; FN_III-like; 1. DR PANTHER; PTHR23256:SF178; Tyr_kinase_insulin_GF_rcpt; 1. DR PANTHER; PTHR23256; Tyr_prot_kinase; 1. DR Pfam; PF00041; fn3; 3. DR Pfam; PF00757; Furin-like; 1. DR Pfam; PF07714; Pkinase_Tyr; 1. DR Pfam; PF01030; Recep_L_domain; 2. DR PIRSF; PIRSF000620; Insulin_receptor; 1. DR SMART; SM00060; FN3; 3. DR SMART; SM00261; FU; 1. DR SMART; SM00219; TyrKc; 1. DR PROSITE; PS50853; FN3; 4. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1. DR PROSITE; PS00239; RECEPTOR_TYR_KIN_II; 1. PE 3: Inferred from homology; KW ATP-binding; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; KW Receptor; Transferase; Transmembrane; Tyrosine-protein kinase. SQ SEQUENCE 1336 AA; 151287 MW; 763A2E02244BDA7B CRC64; MRVVDKMAGL MWAALTLVIG LGLLVPSNGE EYICDSMDIR NRVTNLRQLE NCTVIEGYLQ ILLIDFAEEQ DYRGLSFPNL VEITDYFLLY RVRGLTNLSE LFPNLAVIRG TNLFFNYALV VFEMLDMQKI GLYSLQNITR GSVRIEKNPN LCYLDTIDWS FIAESGYRNN FIVDNRDEEE CGYCPKRCRN ENPVVLQDLC WAEEHCQKVC PESCLGNCLD GSSGCCHENC IGGCDGPTER DCVACKYFVH NGECLIQCPP DTYQYKDRRC ITEDECPNTT NAVWKLHHRK CIPECPSGYT TDVNNPRLCT ECEGQCPKYN IITELEENLG LIEEVGHYVA IVRSYALVTL DFLRSLKRIR GIQKENGYAF YVLDNRNLEK LFEWDRTDLT IDEGKLFFHF NPKLCRHVIL TMVEKVGLPP DTITDTDIST LTNGDQAQCS FSRLEIEEIN TRKDMIILRW SEFTPPDPRD LLSYTVSYRE TEEQGIDEYD GQDACGNTEW KEFDVSPDQR AHIITGLKPW TQYALLVKTY TKAGAREGSG AKSDIVYART DADKPTHPQD VVVYSNSSNT LIITWKPPNR PNGNVTHYIV RYKRQLEEED SMEHREYCIG GLKPHRPTQG LEDIVNNEEE PNNGTIGDGT CCECPKSEDE IRIEEEEAAF QQEFENFLHN NVYHKRENET RAGRRRRELP VTARPFYSNQ TVNVTLPSTN TTAPPTPTPN PNPQLETTVW NEHMVVLTGL RHFSEYIIEV IACNADVINV GCSGSAVELA RTQADDSADN IPGNITVDVG VDVETKVKMA KLYWPKPYQP NSMVVLYNVE YKKLGADGNY EQPQQKCVES YKLMEQQGYT ISNLVAGNYS VRVQATSFAG NGSWSNYVTF YVEEEDTSPA NQDPQQQVPV SLMIGMGVGF SLLVLLAVVF AFWYCTKKRF GDKQMPNGVL YASVNPEYMS SADVYVPDEW EVPREKITLI RELGQGSFGM VYEGEAKDLV KDEPMVSVAV KTVNESASIR ERIEFLNEAS VMKTFNCHHV VKLMGVVSKG QPTLVVMELM ALGDLKNYLR RHRPEEDAGL SDSPASNEAK NSPFAENDND PPPTFKDIIQ MAGEIADGMS YLAAKKFVHR DLACRNCMVA QDRTVKIGDF GMTRDIYETD YYRKGGKGLL PVRWMSPESL KDGVFTSQSD VWSYGVVLWE MATLASQPYQ GKSNEEVLKF VIDGGMLEKP EGCPNKLYDL MKLCWQYRQS MRPTFLEIVE ILSPELQAHF AEVSFYHSLD NHGREPLEMD DVALDSGADT ETEMYPSGSE FSSTPSPPSE TPYSHMNGSH PQNGSMNLRI PKSTLC //