ID   C3XW70_BRAFL            Unreviewed;       743 AA.
AC   C3XW70;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   07-SEP-2016, entry version 43.
DE   RecName: Full=Guanine nucleotide-binding protein subunit gamma {ECO:0000256|RuleBase:RU004973};
GN   ORFNames=BRAFLDRAFT_117155 {ECO:0000313|EMBL:EEN67604.1};
OS   Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC   Eukaryota; Metazoa; Chordata; Cephalochordata; Branchiostomidae;
OC   Branchiostoma.
OX   NCBI_TaxID=7739 {ECO:0000313|Proteomes:UP000001554};
RN   [1] {ECO:0000313|EMBL:EEN67604.1, ECO:0000313|Proteomes:UP000001554}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN67604.1,
RC   ECO:0000313|Proteomes:UP000001554};
RC   TISSUE=Testes {ECO:0000313|EMBL:EEN67604.1};
RX   PubMed=18563158; DOI=10.1038/nature06967;
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA   Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA   Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J.,
RA   Gibson-Brown J.J., Grigoriev I.V., Horton A.C., de Jong P.J.,
RA   Jurka J., Kapitonov V.V., Kohara Y., Kuroki Y., Lindquist E.,
RA   Lucas S., Osoegawa K., Pennacchio L.A., Salamov A.A., Satou Y.,
RA   Sauka-Spengler T., Schmutz J., Shin-I T., Toyoda A.,
RA   Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA   Satoh N., Rokhsar D.S.;
RT   "The amphioxus genome and the evolution of the chordate karyotype.";
RL   Nature 453:1064-1071(2008).
CC   -!- FUNCTION: Guanine nucleotide-binding proteins (G proteins) are
CC       involved as a modulator or transducer in various transmembrane
CC       signaling systems. The beta and gamma chains are required for the
CC       GTPase activity, for replacement of GDP by GTP, and for G protein-
CC       effector interaction. {ECO:0000256|RuleBase:RU004973}.
CC   -!- SUBUNIT: G proteins are composed of 3 units, alpha, beta and
CC       gamma. {ECO:0000256|SAAS:SAAS00551442}.
CC   -!- SUBUNIT: G proteins are composed of 3 units; alpha, beta and
CC       gamma. {ECO:0000256|RuleBase:RU004973}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU004973}; Lipid-anchor
CC       {ECO:0000256|RuleBase:RU004973}; Cytoplasmic side
CC       {ECO:0000256|RuleBase:RU004973}.
CC   -!- SIMILARITY: Belongs to the G protein gamma family.
CC       {ECO:0000256|RuleBase:RU004973}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; GG666471; EEN67604.1; -; Genomic_DNA.
DR   RefSeq; XP_002611594.1; XM_002611548.1.
DR   STRING; 7739.JGI117155; -.
DR   GeneID; 7207805; -.
DR   KEGG; bfo:BRAFLDRAFT_117155; -.
DR   eggNOG; KOG4119; Eukaryota.
DR   eggNOG; KOG4171; Eukaryota.
DR   eggNOG; COG2114; LUCA.
DR   InParanoid; C3XW70; -.
DR   KO; K12319; -.
DR   OMA; QPGRINI; -.
DR   Proteomes; UP000001554; Partially assembled WGS sequence.
DR   GO; GO:0008074; C:guanylate cyclase complex, soluble; IBA:GO_Central.
DR   GO; GO:0005834; C:heterotrimeric G-protein complex; IEA:InterPro.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004383; F:guanylate cyclase activity; IBA:GO_Central.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW.
DR   GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   CDD; cd00068; GGL; 1.
DR   Gene3D; 3.30.70.1230; -; 1.
DR   Gene3D; 4.10.260.10; -; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR015898; G-protein_gamma-like_dom.
DR   InterPro; IPR001770; Gprotein-gamma.
DR   InterPro; IPR011644; Heme_NO-bd.
DR   InterPro; IPR011645; HNOB_dom_associated.
DR   InterPro; IPR024096; NO_sig/Golgi_transp_ligand-bd.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   Pfam; PF00631; G-gamma; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF07700; HNOB; 1.
DR   Pfam; PF07701; HNOBA; 1.
DR   PRINTS; PR00321; GPROTEING.
DR   SMART; SM00044; CYCc; 1.
DR   SMART; SM00224; GGL; 1.
DR   SUPFAM; SSF111126; SSF111126; 1.
DR   SUPFAM; SSF48670; SSF48670; 1.
DR   SUPFAM; SSF55073; SSF55073; 2.
DR   PROSITE; PS50058; G_PROTEIN_GAMMA; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|RuleBase:RU004973};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001554};
KW   Lipoprotein {ECO:0000256|RuleBase:RU004973};
KW   Membrane {ECO:0000256|RuleBase:RU004973};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001554};
KW   Transducer {ECO:0000256|RuleBase:RU004973,
KW   ECO:0000256|SAAS:SAAS00551443}.
FT   DOMAIN        1     47       G protein gamma. {ECO:0000259|PROSITE:
FT                                PS50058}.
FT   DOMAIN      570    727       Guanylate cyclase. {ECO:0000259|PROSITE:
FT                                PS50125}.
SQ   SEQUENCE   743 AA;  83147 MW;  C4C42EBCFD8B532A CRC64;
     MSNSIAQAHK TVDQLRFEAQ IERIRVSKAA ADLQAYCEQH ARDDPLLDSA AEVETKIVVL
     QRRYAPQQQE VTTITVESAG NKSWYRTRVF YWDVPAENSG DISREVDVEE HVTSRRVILI
     FNFAENQTFV RVHPLCAGGS GGSWLRRVDM AAHRKIGMTS QRVVRMKRKA ERFAKFVGFA
     PTHGGANVHQ ISREAVLESM GEHFVRYCIE FGFGSLLRVL GGSLKDFLCN LDSLHEHLAS
     TYPGIRSPSF CCTEGPDDTL FLHYYSERSG LYPIVKGLVR MIAKEFFNVS VAVDVVSEER
     ELTSCQGQVV TFSIRHLSCN GDPPGDEKRL SSGTICPTTS SDPKDLPLSV DTFNDIFPFH
     VMLDRDLKVV QMGRSLKRLL KSNVTSAELR FQDIFEIIRP KVESLFSDIV RHLNTIYVVR
     TVQGIINKGK DCTAQACEGA SNSASVDVEE STLRLKGEMV FVTESDMLLF LCSPRVKDLS
     EFLRKGLYFS DTPLHDSSRD VLMVNYLRRR ERDLLDKIED VGNQLRKLQG RLSEDKRRTE
     ELLHSILPSN AVQSLVSNSP VEAEAHPVVS ILFSDIVNFT GICERVEPMD IVRMLNKLYT
     SFDVLSKLNE LYKVETIGDA YMVAGGIPEK VDDHADRVVT MAVGMMDVSR TVTSPDGDKP
     ISIRVPETLS RYLAYECVQN TLLSSMSLPF QIRVGVHSGP CMAGVVGTTM PRYCLFGNTV
     SLASKMESCS QPGKINISDA TKM
//