ID C3SDV8_ECOLX Unreviewed; 1073 AA. AC C3SDV8; A0A0J3WC61; DT 16-JUN-2009, integrated into UniProtKB/TrEMBL. DT 16-JUN-2009, sequence version 1. DT 20-JUN-2018, entry version 76. DE RecName: Full=Carbamoyl-phosphate synthase large chain {ECO:0000256|HAMAP-Rule:MF_01210}; DE EC=6.3.5.5 {ECO:0000256|HAMAP-Rule:MF_01210}; DE AltName: Full=Carbamoyl-phosphate synthetase ammonia chain {ECO:0000256|HAMAP-Rule:MF_01210}; GN Name=carB {ECO:0000256|HAMAP-Rule:MF_01210, GN ECO:0000313|EMBL:AMW44268.1}; GN ORFNames=A8G17_15490 {ECO:0000313|EMBL:OWC13582.1}, A9819_00055 GN {ECO:0000313|EMBL:PBT46015.1}, AML35_12405 GN {ECO:0000313|EMBL:KYS93018.1}, ARC77_19490 GN {ECO:0000313|EMBL:AMW44268.1}, AU473_26660 GN {ECO:0000313|EMBL:APA44248.1}, B7C53_02095 GN {ECO:0000313|EMBL:OWS87473.1}, BMR14_14505 GN {ECO:0000313|EMBL:PGG46907.1}, BTQ04_23025 GN {ECO:0000313|EMBL:PAU10297.1}, BWP17_03630 GN {ECO:0000313|EMBL:OOC84640.1}, CA268_07530 GN {ECO:0000313|EMBL:ARR59278.1}, CR539_04160 GN {ECO:0000313|EMBL:AUJ94691.1}, CVH05_13310 GN {ECO:0000313|EMBL:PJG33213.1}, ECs0036 {ECO:0000313|EMBL:ACI72662.1}, GN ERS085383_01317 {ECO:0000313|EMBL:CTT65455.1}, ERS085404_00849 GN {ECO:0000313|EMBL:CTU68078.1}, YDC107_3260 GN {ECO:0000313|EMBL:AUO35411.1}; OS Escherichia coli. OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Escherichia. OX NCBI_TaxID=562 {ECO:0000313|EMBL:ACI72662.1}; RN [1] {ECO:0000313|EMBL:ACI72662.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=86-24 {ECO:0000313|EMBL:ACI72662.1}, 87-14 RC {ECO:0000313|EMBL:ACI72663.1}, and TW14359 RC {ECO:0000313|EMBL:ACI72664.1}; RX PubMed=19439656; DOI=10.1073/pnas.0812949106; RA Leopold S.R., Magrini V., Holt N.J., Shaikh N., Mardis E.R., Cagno J., RA Ogura Y., Iguchi A., Hayashi T., Mellmann A., Karch H., Besser T.E., RA Sawyer S.A., Whittam T.S., Tarr P.I.; RT "A precise reconstruction of the emergence and constrained radiations RT of Escherichia coli O157 portrayed by backbone concatenomic RT analysis."; RL Proc. Natl. Acad. Sci. U.S.A. 106:8713-8718(2009). RN [2] {ECO:0000313|EMBL:CTT65455.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=200758_aEPEC {ECO:0000313|EMBL:CTT65455.1}, and RC 702745_aEPEC {ECO:0000313|EMBL:CTU68078.1}; RA Rikkerink E.H.A., Fineran P.C.; RT "Complete DNA Sequence of Pseudomonas syringae pv. actinidiae, the RT Causal Agent of Kiwifruit Canker Disease."; RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Proteomes:UP000043139, ECO:0000313|Proteomes:UP000044658} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=200758_aEPEC {ECO:0000313|Proteomes:UP000044658}, and RC 702745_aEPEC {ECO:0000313|Proteomes:UP000043139}; RG Pathogen Informatics; RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|Proteomes:UP000076106} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=STEC 1686 {ECO:0000313|Proteomes:UP000076106}; RA Shamseldin A., Moawad H., Abd El-Rahim W.M., Sadowsky M.J.; RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|EMBL:ARR59278.1, ECO:0000313|Proteomes:UP000194331} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Z1002 {ECO:0000313|EMBL:ARR59278.1}; RX PubMed=27506685; DOI=.1093/cid/ciw553; RA Zheng B., Dong H., Xu H., Lv J., Zhang J., Jiang X., Du Y., Xiao Y., RA Li L.; RT "Coexistence of MCR-1 and NDM-1 in Clinical Escherichia coli RT Isolates."; RL Clin. Infect. Dis. 63:1393-1395(2016). RN [6] {ECO:0000313|EMBL:KYS93018.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=STEC 1686 {ECO:0000313|EMBL:KYS93018.1}; RX PubMed=27058887; RA Ferdous M., Friedrich A.W., Grundmann H., de Boer R.F., Croughs P.D., RA Islam M.A., Kluytmans-van den Bergh M.F., Kooistra-Smid A.M., RA Rossen J.W.; RT "Molecular characterization and phylogeny of Shiga toxin-producing RT Escherichia coli isolates obtained from two Dutch regions using whole RT genome sequencing."; RL Clin. Microbiol. Infect. 22:642-642(2016). RN [7] {ECO:0000313|EMBL:AMW44268.1, ECO:0000313|Proteomes:UP000076266} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=28RC1 {ECO:0000313|EMBL:AMW44268.1, RC ECO:0000313|Proteomes:UP000076266}; RA Baranzoni G.M., Fratamico P., Reichenberger E., Kim G.-H., Breidt F., RA Kay K.; RT "Complete Genome Sequences of Escherichia coli O157:H7 strains SRCC RT 1675 and 28RC."; RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|EMBL:OWC13582.1, ECO:0000313|Proteomes:UP000196865} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ECOR37 {ECO:0000313|EMBL:OWC13582.1, RC ECO:0000313|Proteomes:UP000196865}; RA Fischer W., Schubert S., Messerer M.; RT "Investigation of Horizontal Gene Transfer of Pathogenicity Islands in RT Escherichia coli using Next-Generation Sequencing."; RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:APA44248.1, ECO:0000313|Proteomes:UP000177471} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=PA20 {ECO:0000313|EMBL:APA44248.1, RC ECO:0000313|Proteomes:UP000177471}; RA Uhlich G.A., Chen C.-Y., Paoli G.; RT "E. coli O157:H7 PA20."; RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases. RN [10] {ECO:0000313|EMBL:PGG46907.1, ECO:0000313|Proteomes:UP000224281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=4_Esco_CA-NL {ECO:0000313|EMBL:PGG46907.1, RC ECO:0000313|Proteomes:UP000224281}; RA Garcia-Cobos S.; RT "Genetic relatedness of ESBL-Enterobacteriaceae in hospitals and the RT community, Northern Netherlands and Germany."; RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases. RN [11] {ECO:0000313|EMBL:PAU10297.1, ECO:0000313|Proteomes:UP000218692} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=STEC 621S1 {ECO:0000313|EMBL:PAU10297.1, RC ECO:0000313|Proteomes:UP000218692}; RA Ferdous M., Moran-Gilad J., Rossen J.W., Gdalevich M.; RT "Real-Time Genomic Investigation Underlying the Public Health Response RT to a Shiga Toxin-Producing Escherichia Coli O26:H11 Outbreak in a RT Nursery."; RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases. RN [12] {ECO:0000313|EMBL:OOC84640.1, ECO:0000313|Proteomes:UP000188999} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=EDL 933 {ECO:0000313|EMBL:OOC84640.1, RC ECO:0000313|Proteomes:UP000188999}; RA Kozyreva V.K., Truong C.-L., Greninger A.L., Mukhopadhyay R., RA Crandall J., Chaturvedi V.; RT "Validation and Implementation of CLIA-Compliant Whole Genome RT Sequencing (WGS) in Public Health Laboratory."; RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases. RN [13] {ECO:0000313|EMBL:OWS87473.1, ECO:0000313|Proteomes:UP000197917} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Ec39590 {ECO:0000313|EMBL:OWS87473.1, RC ECO:0000313|Proteomes:UP000197917}; RA Melo L.C., Boisson M.N., Cerdeira L., Saras E., Medaille C., RA Boulois H.-J., Madec J.-Y., Haenni M., Lincopan N.; RT "Draft Genome Sequence of Escherichia coli Isolated from Cat Harboring RT blaTEM-52b."; RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases. RN [14] {ECO:0000313|EMBL:ARR59278.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Z1002 {ECO:0000313|EMBL:ARR59278.1}; RA Song R., Chenine A.L., Ruprecht R.M.; RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases. RN [15] {ECO:0000313|EMBL:PBT46015.1, ECO:0000313|Proteomes:UP000218701} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KCJK3945 {ECO:0000313|EMBL:PBT46015.1, RC ECO:0000313|Proteomes:UP000218701}; RA Ehlers B., Leendertz F.H.; RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases. RN [16] {ECO:0000313|EMBL:AUJ94691.1, ECO:0000313|Proteomes:UP000234543} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=14EC033 {ECO:0000313|EMBL:AUJ94691.1, RC ECO:0000313|Proteomes:UP000234543}; RA Li B., Wang X.; RT "mcr-1 positive E.coli isolates in China."; RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases. RN [17] {ECO:0000313|EMBL:PJG33213.1, ECO:0000313|Proteomes:UP000231208} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KCJ4029 {ECO:0000313|EMBL:PJG33213.1, RC ECO:0000313|Proteomes:UP000231208}; RA Han C.G.; RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases. RN [18] {ECO:0000313|EMBL:AUO35411.1, ECO:0000313|Proteomes:UP000238802} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=YDC107 {ECO:0000313|EMBL:AUO35411.1, RC ECO:0000313|Proteomes:UP000238802}; RA Hazen T.H., Doi Y., Rasko D.A.; RT "Genome sequencing of KPC-containing E. coli."; RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: 2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 CC ADP + phosphate + L-glutamate + carbamoyl phosphate. CC {ECO:0000256|HAMAP-Rule:MF_01210, ECO:0000256|SAAS:SAAS00383240}. CC -!- COFACTOR: CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; CC Evidence={ECO:0000256|SAAS:SAAS00981842}; CC -!- COFACTOR: CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035; CC Evidence={ECO:0000256|SAAS:SAAS00611658}; CC -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; CC carbamoyl phosphate from bicarbonate: step 1/1. CC {ECO:0000256|HAMAP-Rule:MF_01210, ECO:0000256|SAAS:SAAS00981844}. CC -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo CC pathway; (S)-dihydroorotate from bicarbonate: step 1/3. CC {ECO:0000256|HAMAP-Rule:MF_01210, ECO:0000256|SAAS:SAAS01000080}. CC -!- SUBUNIT: Composed of two chains; the small (or glutamine) chain CC promotes the hydrolysis of glutamine to ammonia, which is used by CC the large (or ammonia) chain to synthesize carbamoyl phosphate. CC {ECO:0000256|HAMAP-Rule:MF_01210, ECO:0000256|SAAS:SAAS00570548}. CC -!- SIMILARITY: Belongs to the CarB family. {ECO:0000256|HAMAP- CC Rule:MF_01210, ECO:0000256|SAAS:SAAS00570556}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; EU890076; ACI72662.1; -; Genomic_DNA. DR EMBL; EU890077; ACI72663.1; -; Genomic_DNA. DR EMBL; EU890078; ACI72664.1; -; Genomic_DNA. DR EMBL; CP015020; AMW44268.1; -; Genomic_DNA. DR EMBL; CP017669; APA44248.1; -; Genomic_DNA. DR EMBL; CP021202; ARR59278.1; -; Genomic_DNA. DR EMBL; CP024147; AUJ94691.1; -; Genomic_DNA. DR EMBL; CP025707; AUO35411.1; -; Genomic_DNA. DR EMBL; CYBJ01000005; CTT65455.1; -; Genomic_DNA. DR EMBL; CYCH01000003; CTU68078.1; -; Genomic_DNA. DR EMBL; LOGT01000127; KYS93018.1; -; Genomic_DNA. DR EMBL; MTFS01000003; OOC84640.1; -; Genomic_DNA. DR EMBL; LYAA01001895; OWC13582.1; -; Genomic_DNA. DR EMBL; NBSF01000002; OWS87473.1; -; Genomic_DNA. DR EMBL; MRVX01000103; PAU10297.1; -; Genomic_DNA. DR EMBL; NTDZ01000001; PBT46015.1; -; Genomic_DNA. DR EMBL; MOXW01000045; PGG46907.1; -; Genomic_DNA. DR EMBL; PGUD01000195; PJG33213.1; -; Genomic_DNA. DR RefSeq; WP_001126371.1; NZ_PUDS01000008.1. DR EnsemblBacteria; AMW44268; AMW44268; ARC77_19490. DR EnsemblBacteria; CTT65455; CTT65455; ERS085383_01317. DR EnsemblBacteria; CTU68078; CTU68078; ERS085404_00849. DR EnsemblBacteria; KLX88163; KLX88163; SK83_02630. DR EnsemblBacteria; KME75368; KME75368; SM09_00774. DR EnsemblBacteria; KYS93018; KYS93018; AML35_12405. DR EnsemblBacteria; ODH24354; ODH24354; A6804_06370. DR EnsemblBacteria; OEG64894; OEG64894; A7H95_14195. DR PATRIC; fig|562.7061.peg.4926; -. DR eggNOG; ENOG4105CU6; Bacteria. DR eggNOG; COG0458; LUCA. DR HOGENOM; HOG000234582; -. DR UniPathway; UPA00068; UER00171. DR UniPathway; UPA00070; UER00115. DR Proteomes; UP000043139; Unassembled WGS sequence. DR Proteomes; UP000044658; Unassembled WGS sequence. DR Proteomes; UP000076106; Unassembled WGS sequence. DR Proteomes; UP000076266; Chromosome. DR Proteomes; UP000177471; Chromosome. DR Proteomes; UP000188999; Unassembled WGS sequence. DR Proteomes; UP000194331; Chromosome. DR Proteomes; UP000196865; Unassembled WGS sequence. DR Proteomes; UP000197917; Unassembled WGS sequence. DR Proteomes; UP000218692; Unassembled WGS sequence. DR Proteomes; UP000218701; Unassembled WGS sequence. DR Proteomes; UP000224281; Unassembled WGS sequence. DR Proteomes; UP000231208; Unassembled WGS sequence. DR Proteomes; UP000234543; Chromosome. DR Proteomes; UP000238802; Chromosome. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0004088; F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; IEA:UniProtKB-UniRule. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway. DR GO; GO:0006526; P:arginine biosynthetic process; IEA:UniProtKB-UniRule. DR CDD; cd01424; MGS_CPS_II; 1. DR Gene3D; 1.10.1030.10; -; 1. DR Gene3D; 3.40.50.1380; -; 1. DR HAMAP; MF_01210_A; CPSase_L_chain_A; 1. DR HAMAP; MF_01210_B; CPSase_L_chain_B; 1. DR InterPro; IPR011761; ATP-grasp. DR InterPro; IPR006275; CarbamoylP_synth_lsu. DR InterPro; IPR005480; CarbamoylP_synth_lsu_oligo. DR InterPro; IPR036897; CarbamoylP_synth_lsu_oligo_sf. DR InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd. DR InterPro; IPR005483; CbamoylP_synth_lsu_CPSase_dom. DR InterPro; IPR011607; MGS-like_dom. DR InterPro; IPR036914; MGS-like_dom_sf. DR InterPro; IPR033937; MGS_CPS_CarB. DR InterPro; IPR016185; PreATP-grasp_dom_sf. DR Pfam; PF02786; CPSase_L_D2; 2. DR Pfam; PF02787; CPSase_L_D3; 1. DR Pfam; PF02142; MGS; 1. DR PRINTS; PR00098; CPSASE. DR SMART; SM01096; CPSase_L_D3; 1. DR SMART; SM00851; MGS; 1. DR SUPFAM; SSF48108; SSF48108; 1. DR SUPFAM; SSF52335; SSF52335; 1. DR SUPFAM; SSF52440; SSF52440; 2. DR TIGRFAMs; TIGR01369; CPSaseII_lrg; 1. DR PROSITE; PS50975; ATP_GRASP; 2. DR PROSITE; PS00866; CPSASE_1; 2. DR PROSITE; PS00867; CPSASE_2; 2. PE 3: Inferred from homology; KW Amino-acid biosynthesis {ECO:0000256|HAMAP-Rule:MF_01210, KW ECO:0000256|SAAS:SAAS00981831}; KW Arginine biosynthesis {ECO:0000256|HAMAP-Rule:MF_01210, KW ECO:0000256|SAAS:SAAS00981841}; KW ATP-binding {ECO:0000256|HAMAP-Rule:MF_01210, ECO:0000256|PROSITE- KW ProRule:PRU00409, ECO:0000256|SAAS:SAAS00710217}; KW Complete proteome {ECO:0000313|Proteomes:UP000043139, KW ECO:0000313|Proteomes:UP000044658, ECO:0000313|Proteomes:UP000076106, KW ECO:0000313|Proteomes:UP000076266}; KW Ligase {ECO:0000256|HAMAP-Rule:MF_01210, KW ECO:0000256|SAAS:SAAS00710245, ECO:0000313|EMBL:AUJ94691.1}; KW Magnesium {ECO:0000256|SAAS:SAAS00981805}; KW Manganese {ECO:0000256|SAAS:SAAS00511130}; KW Metal-binding {ECO:0000256|SAAS:SAAS00511109}; KW Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_01210, KW ECO:0000256|PROSITE-ProRule:PRU00409, ECO:0000256|SAAS:SAAS00710285}; KW Pyrimidine biosynthesis {ECO:0000256|HAMAP-Rule:MF_01210, KW ECO:0000256|SAAS:SAAS01000143}; KW Repeat {ECO:0000256|HAMAP-Rule:MF_01210, KW ECO:0000256|SAAS:SAAS00981845}. FT DOMAIN 133 328 ATP-grasp. {ECO:0000259|PROSITE:PS50975}. FT DOMAIN 679 870 ATP-grasp. {ECO:0000259|PROSITE:PS50975}. FT REGION 1 403 Carboxyphosphate synthetic domain. FT {ECO:0000256|HAMAP-Rule:MF_01210}. FT REGION 404 553 Oligomerization domain. FT {ECO:0000256|HAMAP-Rule:MF_01210}. FT REGION 554 936 Carbamoyl phosphate synthetic domain. FT {ECO:0000256|HAMAP-Rule:MF_01210}. FT REGION 937 1073 Allosteric domain. {ECO:0000256|HAMAP- FT Rule:MF_01210}. SQ SEQUENCE 1073 AA; 117856 MW; F29E5AA657BE6355 CRC64; MPKRTDIKSI LILGAGPIVI GQACEFDYSG AQACKALREE GYRVILVNSN PATIMTDPEM ADATYIEPIH WEVVRKIIEK ERPDAVLPTM GGQTALNCAL ELERQGVLEE FGVTMIGATA DAIDKAEDRR RFDVAMKKIG LETARSGIAH TMEEALAVAA DVGFPCIIRP SFTMGGSGGG IAYNREEFEE ICARGLDLSP TKELLIDESL IGWKEYEMEV VRDKNDNCII VCSIENFDAM GIHTGDSITV APAQTLTDKE YQIMRNASMA VLREIGVETG GSNVQFAVNP KNGRLIVIEM NPRVSRSSAL ASKATGFPIA KVAAKLAVGY TLDELMNDIT GGRTPASFEP SIDYVVTKIP RFNFEKFAGA NDRLTTQMKS VGEVMAIGRT QQESLQKALR GLEVGATGFD PKVSLDDPEA LTKIRRELKD AGAERIWYIA DAFRAGLSVD GVFNLTNIDR WFLVQIEELV RLEEKVAEVG ITGLNAEFLR QLKRKGFADA RLAKLAGVRE AEIRKLRDQY DLHPVYKRVD TCAAEFATDT AYMYSTYEEE CEANPSTDRE KIMVLGGGPN RIGQGIEFDY CCVHASLALR EDGYETIMVN CNPETVSTDY DTSDRLYFEP VTLEDVLEIV RIEKPKGVIV QYGGQTPLKL ARALEAAGVP VIGTSPDAID RAEDRERFQH AVDRLKLKQP ANATVTAIEM AVEKAKEIGY PLVVRPSYVL GGRAMEIVYD EADLRRYFQT AVSVSNDAPV LLDHFLDDAV EVDVDAICDG EMVLIGGIME HIEQAGVHSG DSACSLPAYT LSQEIQDVMR QQVQKLAFEL QVRGLMNVQF AVKNNEVYLI EVNPRAARTV PFVSKATGVP LAKVAARVMA GKSLAEQGVT KEVIPPYYSV KEVVLPFNKF PGVDPLLGPE MRSTGEVMGV GRTFAEAFAK AQLGSNSTMK KHGRALLSVR EGDKERVVDL AAKLLKQGFE LDATHGTAIV LGEAGINPRL VNKVHEGRPH IQDRIKNGEY TYIINTTSGR RAIEDSRVIR RSALQYKVHY DTTLNGGFAT AMALNADATE KVISVQEMHA QIK //