ID C3PPP4_9INFA Unreviewed; 90 AA. AC C3PPP4; DT 16-JUN-2009, integrated into UniProtKB/TrEMBL. DT 16-JUN-2009, sequence version 1. DT 18-APR-2012, entry version 9. DE SubName: Full=PB1-F2 protein; GN Name=PB1-F2; OS Influenza A virus (A/chicken/Pakistan/UDL-02/2006(H9N2)). OC Viruses; ssRNA negative-strand viruses; Orthomyxoviridae; OC Influenzavirus A. OX NCBI_TaxID=632131; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=A/chicken/Pakistan/UDL-02/2006; RX PubMed=19517011; DOI=10.1371/journal.pone.0005788; RA Iqbal M., Yaqub T., Reddy K., McCauley J.W.; RT "Novel genotypes of H9N2 influenza A viruses isolated from poultry in RT Pakistan containing NS genes similar to highly pathogenic H7N3 and RT H5N1 viruses."; RL PLoS ONE 4:E5788-E5788(2009). CC -!- FUNCTION: Plays an important role in promoting lung pathology in CC both primary viral infection and secondary bacterial infection. CC Promotes alteration of mitochondrial morphology, dissipation of CC mitochondrial membrane potential, and cell death. Alternatively, CC inhibits the production of interferon in the infected cell at the CC level of host mitochondrial antiviral signaling MAVS. Its level of CC expression differs greatly depending on which cell type is CC infected, in a manner that is independent of the levels of CC expression of other viral proteins. Monocytic cells are more CC affected than epithelial cells. Seems to disable virus-infected CC monocytes or other host innate immune cells. May also act in CC trans: extracellular PB1-F2 released by infected cells could CC potentially inactivate hosts cell recruitment to the site of CC infection. During early stage of infection, may predispose the CC mitochondria to permeability transition through interaction with CC human SLC25A6/ANT3 and VDAC1. These proteins participate in the CC formation of the permeability transition pore complex (PTPC) CC responsible of the release of mitochondrial products that triggers CC apoptosis (By similarity). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CY038432; ACP50673.1; -; Viral_cRNA. DR GO; GO:0044192; C:host cell mitochondrial inner membrane; IEA:UniProtKB-KW. DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-KW. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. DR GO; GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW. DR InterPro; IPR021045; Flu_proapoptotic_PB1-F2. DR Pfam; PF11986; PB1-F2; 1. PE 3: Inferred from homology; KW Apoptosis; Host cytoplasm; Host membrane; Host mitochondrion; KW Host mitochondrion inner membrane; Host nucleus; KW Host-virus interaction; KW Inhibition of host IFN-mediated response initiation by virus; KW Inhibition of host innate immune response by virus; KW Inhibition of host MAVS by virus; Membrane; KW Modulation of host cell apoptosis by virus. SQ SEQUENCE 90 AA; 10998 MW; 20FC5D4D7346A2E3 CRC64; MEQEQDTPWT QSIERINTQR REDGQQIQRR EPPNSIQLMG RYLRITSQAD MHRQIVCWKR WLSLKNPIRG SLKTHVLKRW KLSSKQEWIN //