ID   C3PPP4_9INFA            Unreviewed;        90 AA.
AC   C3PPP4;
DT   16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT   16-JUN-2009, sequence version 1.
DT   29-MAY-2013, entry version 14.
DE   SubName: Full=PB1-F2 protein;
GN   Name=PB1-F2;
OS   Influenza A virus (A/chicken/Pakistan/UDL-02/2006(H9N2)).
OC   Viruses; ssRNA negative-strand viruses; Orthomyxoviridae;
OC   Influenzavirus A.
OX   NCBI_TaxID=632131;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=A/chicken/Pakistan/UDL-02/2006;
RX   PubMed=19517011; DOI=10.1371/journal.pone.0005788;
RA   Iqbal M., Yaqub T., Reddy K., McCauley J.W.;
RT   "Novel genotypes of H9N2 influenza A viruses isolated from poultry in
RT   Pakistan containing NS genes similar to highly pathogenic H7N3 and
RT   H5N1 viruses.";
RL   PLoS ONE 4:E5788-E5788(2009).
CC   -!- FUNCTION: Plays an important role in promoting lung pathology in
CC       both primary viral infection and secondary bacterial infection.
CC       Promotes alteration of mitochondrial morphology, dissipation of
CC       mitochondrial membrane potential, and cell death. Alternatively,
CC       inhibits the production of interferon in the infected cell at the
CC       level of host mitochondrial antiviral signaling MAVS. Its level of
CC       expression differs greatly depending on which cell type is
CC       infected, in a manner that is independent of the levels of
CC       expression of other viral proteins. Monocytic cells are more
CC       affected than epithelial cells. Seems to disable virus-infected
CC       monocytes or other host innate immune cells. May also act in
CC       trans: extracellular PB1-F2 released by infected cells could
CC       potentially inactivate hosts cell recruitment to the site of
CC       infection. During early stage of infection, may predispose the
CC       mitochondria to permeability transition through interaction with
CC       human SLC25A6/ANT3 and VDAC1. These proteins participate in the
CC       formation of the permeability transition pore complex (PTPC)
CC       responsible of the release of mitochondrial products that triggers
CC       apoptosis (By similarity).
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DR   EMBL; CY038432; ACP50673.1; -; Viral_cRNA.
DR   GO; GO:0044192; C:host cell mitochondrial inner membrane; IEA:UniProtKB-KW.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0039526; P:modulation by virus of host apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0039545; P:suppression by virus of host MAVS activity; IEA:UniProtKB-KW.
DR   GO; GO:0039501; P:suppression by virus of host type I interferon production; IEA:UniProtKB-KW.
DR   InterPro; IPR021045; Flu_proapoptotic_PB1-F2.
DR   Pfam; PF11986; PB1-F2; 1.
PE   3: Inferred from homology;
KW   Apoptosis; Host cytoplasm; Host membrane; Host mitochondrion;
KW   Host mitochondrion inner membrane; Host nucleus;
KW   Host-virus interaction;
KW   Inhibition of host IFN-mediated response initiation by virus;
KW   Inhibition of host innate immune response by virus;
KW   Inhibition of host MAVS by virus; Membrane;
KW   Modulation of host cell apoptosis by virus; Viral immunoevasion.
SQ   SEQUENCE   90 AA;  10998 MW;  20FC5D4D7346A2E3 CRC64;
     MEQEQDTPWT QSIERINTQR REDGQQIQRR EPPNSIQLMG RYLRITSQAD MHRQIVCWKR
     WLSLKNPIRG SLKTHVLKRW KLSSKQEWIN
//