ID C1ILQ3_HRSV Unreviewed; 117 AA. AC C1ILQ3; DT 26-MAY-2009, integrated into UniProtKB/TrEMBL. DT 26-MAY-2009, sequence version 1. DT 10-FEB-2021, entry version 27. DE RecName: Full=Major surface glycoprotein G {ECO:0000256|RuleBase:RU363027}; DE AltName: Full=Attachment glycoprotein G {ECO:0000256|RuleBase:RU363027}; DE Flags: Fragment; GN Name=G {ECO:0000256|RuleBase:RU363027}; OS Human respiratory syncytial virus. OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina; OC Monjiviricetes; Mononegavirales; Pneumoviridae; Orthopneumovirus. OX NCBI_TaxID=11250 {ECO:0000313|EMBL:ACF28511.1}; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] {ECO:0000313|EMBL:ACF28511.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=KOL/117/05/B {ECO:0000313|EMBL:ACF28511.1}; RA Agrawal A.S., Naik T.N., Sarkar M.; RT "Surface Glycoprotein G encoding gene of Human Respiratory Syncytial RT Virus(HRSV), B Subgroup."; RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Helps the virus escape antibody-dependent restriction of CC replication by acting as an antigen decoy and by modulating the CC activity of leukocytes bearing Fc-gamma receptors. CC {ECO:0000256|ARBA:ARBA00023752}. CC -!- FUNCTION: [Isoform Secreted glycoprotein G]: Helps the virus escape CC antibody-dependent restriction of replication by acting as an antigen CC decoy and by modulating the activity of leukocytes bearing Fc-gamma CC receptors. {ECO:0000256|RuleBase:RU363027}. CC -!- SUBUNIT: [Isoform Membrane-bound glycoprotein G]: Homooligomer. CC Interacts (via N-terminus) with protein M. Part of a complex composed CC of F1, F2 and G glycoproteins. Interacts with protein SH. Interacts CC with host heparate sulfate; this interaction probably participates in CC the viral attachment to the host cell. {ECO:0000256|RuleBase:RU363027}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401}; CC Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}. CC Host cell membrane {ECO:0000256|ARBA:ARBA00004336}; Single-pass type II CC membrane protein {ECO:0000256|ARBA:ARBA00004336}. Membrane CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein CC {ECO:0000256|ARBA:ARBA00004606}. Secreted CC {ECO:0000256|RuleBase:RU363027}. Virion membrane CC {ECO:0000256|RuleBase:RU363027}. CC -!- SIMILARITY: Belongs to the pneumoviruses glycoprotein G family. CC {ECO:0000256|ARBA:ARBA00007101, ECO:0000256|RuleBase:RU363027}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; EU604793; ACF28511.1; -; Viral_cRNA. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0044228; C:host cell surface; IEA:UniProtKB-SubCell. DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell. DR GO; GO:0030683; P:mitigation of host immune response by virus; IEA:UniProtKB-KW. DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW. DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW. DR InterPro; IPR000925; G_prot. DR Pfam; PF00802; Glycoprotein_G; 1. PE 3: Inferred from homology; KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511}; KW Host membrane {ECO:0000256|ARBA:ARBA00022870}; KW Host-virus interaction {ECO:0000256|RuleBase:RU363027}; KW Membrane {ECO:0000256|ARBA:ARBA00022870}; KW Secreted {ECO:0000256|RuleBase:RU363027}; KW Viral attachment to host cell {ECO:0000256|RuleBase:RU363027}; KW Viral immunoevasion {ECO:0000256|RuleBase:RU363027}; KW Virion {ECO:0000256|RuleBase:RU363027}; KW Virus entry into host cell {ECO:0000256|RuleBase:RU363027}. FT REGION 1..117 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 13..27 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 28..117 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:ACF28511.1" FT NON_TER 117 FT /evidence="ECO:0000313|EMBL:ACF28511.1" SQ SEQUENCE 117 AA; 12755 MW; 3385331A1E137A6F CRC64; KKPTTKPTNK PPTKTTNKRD PKTPAKTPKK ETTINPTKKP TPKTTERDTS TPQSTVLDTT TSKHTERDTS TSQSIVLDTT TSKHTIQQQS LYSTTPENTP NSTKTPTASE PSTSNST //