ID C0JRM0_9INFA Unreviewed; 560 AA. AC C0JRM0; DT 05-MAY-2009, integrated into UniProtKB/TrEMBL. DT 05-MAY-2009, sequence version 1. DT 19-JAN-2010, entry version 9. DE SubName: Full=Hemagglutinin; GN Name=HA; OS Influenza A virus (A/chicken/Anhui/AH16/2008(H9N2)). OC Viruses; ssRNA negative-strand viruses; Orthomyxoviridae; OC Influenzavirus A. OX NCBI_TaxID=572976; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=A/chicken/Anhui/AH16/2008; RA Ji K., Jiang W.M., Chen J.M., Liu S., Chen J., Hou G., Li J., RA Huang B.; RT "Characterization of the hemagglutinin gene of subtype H9 avian RT influenza viruses isolated in 2007-2008 in China mainland."; RL Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Binds to sialic acid-containing receptors on the cell CC surface, bringing about the attachment of the virus particle to CC the cell. Plays a major role in the determination of host range CC restriction and virulence. Class I viral fusion protein. CC Responsible for penetration of the virus into the cell cytoplasm CC by mediating the fusion of the membrane of the endocytosed virus CC particle with the endosomal membrane. Low pH in endosomes induce CC an irreversible conformational change in HA2, releasing the fusion CC hydrophobic peptide. Several trimers are required to form a CC competent fusion pore (By similarity). CC -!- SUBUNIT: Homotrimer of disulfide-linked HA1-HA2 (By similarity). CC -!- SUBCELLULAR LOCATION: Virion membrane; Single-pass type I membrane CC protein (Potential). Host apical cell membrane; Single-pass type I CC membrane protein. CC -!- SIMILARITY: Belongs to the influenza viruses hemagglutinin family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; FJ434579; ACJ35235.1; -; Viral_cRNA. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-SubCell. DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW. DR GO; GO:0046789; F:host cell surface receptor binding; IEA:InterPro. DR GO; GO:0019064; P:viral envelope fusion with host membrane; IEA:InterPro. DR InterPro; IPR008980; Capsid_hemagglutn. DR InterPro; IPR013827; Hemagglutn_HA1_b-rbn_dom. DR InterPro; IPR000149; Hemagglutn_influenz_HA1. DR InterPro; IPR001364; Hemagglutn_influenz_HA1/HA2. DR InterPro; IPR013829; Hemagglutn_stalk. DR Gene3D; G3DSA:2.10.77.10; Haemagglutn_HA1_b-ribbon; 1. DR Gene3D; G3DSA:3.90.20.10; Haemagglutn_stalk; 1. DR Pfam; PF00509; Hemagglutinin; 1. DR PRINTS; PR00330; HEMAGGLUTN1. DR PRINTS; PR00329; HEMAGGLUTN12. PE 3: Inferred from homology; KW Envelope protein; Fusion protein; Hemagglutinin; Host cell membrane; KW Host membrane; Membrane; Transmembrane; Virion. SQ SEQUENCE 560 AA; 62675 MW; 76B576BF9412B81B CRC64; METVSLITML LVVTVINADK ICIGYQSTNS TETVDTLTEN NVPVTHAKEL LHTEHNGMLC ATNLGHPLIL DTCTIEGLIY GNPSCDLLLG GGEWSYIVER PSAVNGLCYP GNVENLEELR SLFSSASSYQ RIQIFPDTIW NVSYSGTSKA CSDSFYRSMR WLTQKNNAYP IQDAQYTNNR EKNILFMWGI NQPPTETAQT NLYTRTDTTT SVATEEINRT FKPLIGPRPL VNGLQGRIDY YWSVLKPGQT LRIRSNGNLI APWYGHILSG ESHGRILKTD LKRGSCTVQC QTEKGGLNTT LPFQNVSKYA FGNCSKYVGI KSLKLAVGLR NVPSRSSRGL FGAIAGFIEG GWSGLVAGWY GFQHSNDQGV GMAADRDSTQ KAIDKITSKV NNIVDKMNKQ YEIIDHEFSE VENRLNMINN KIDDQIQDIW AYNAELLVLL ENQKTLDEHD ANVNNLYNKV KRALGSNAVE DGKGCFELYH KCDDQCMETI RNGTYNRRKY QEESKLKRQR IEGVKLESEG TYKILTIYST VASSLVIAMG FAAFLFWAMS NGSCRCNICI //