ID C0J7S9_9NEOB Unreviewed; 173 AA. AC C0J7S9; DT 05-MAY-2009, integrated into UniProtKB/TrEMBL. DT 05-MAY-2009, sequence version 1. DT 24-JUL-2024, entry version 37. DE RecName: Full=Tyrosinase {ECO:0000256|ARBA:ARBA00039304}; DE EC=1.14.18.1 {ECO:0000256|ARBA:ARBA00011906}; DE AltName: Full=Monophenol monooxygenase {ECO:0000256|ARBA:ARBA00042251}; DE Flags: Fragment; OS Feihyla vittatus (striped Asian treefrog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; OC Batrachia; Anura; Neobatrachia; Ranoidea; Rhacophoridae; Rhacophorinae; OC Feihyla. OX NCBI_TaxID=2773507 {ECO:0000313|EMBL:ACL36639.1}; RN [1] {ECO:0000313|EMBL:ACL36639.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=KIZ060821090 {ECO:0000313|EMBL:ACL36639.1}; RX PubMed=19100849; DOI=10.1016/j.ympev.2008.11.023; RA Yu G., Rao D., Zhang M., Yang J.; RT "Re-examination of the phylogeny of Rhacophoridae (Anura) based on RT mitochondrial and nuclear DNA."; RL Mol. Phylogenet. Evol. 50:571-579(2009). CC -!- COFACTOR: CC Name=Cu(2+); Xref=ChEBI:CHEBI:29036; CC Evidence={ECO:0000256|ARBA:ARBA00001973}; CC -!- SUBCELLULAR LOCATION: Melanosome membrane CC {ECO:0000256|ARBA:ARBA00004573}; Single-pass type I membrane protein CC {ECO:0000256|ARBA:ARBA00004573}. CC -!- SIMILARITY: Belongs to the tyrosinase family. CC {ECO:0000256|ARBA:ARBA00009928}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; EU924568; ACL36639.1; -; Genomic_DNA. DR AlphaFoldDB; C0J7S9; -. DR GO; GO:0033162; C:melanosome membrane; IEA:UniProtKB-SubCell. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0004503; F:tyrosinase activity; IEA:TreeGrafter. DR GO; GO:0042438; P:melanin biosynthetic process; IEA:UniProtKB-KW. DR GO; GO:0043473; P:pigmentation; IEA:TreeGrafter. DR CDD; cd00055; EGF_Lam; 1. DR Gene3D; 1.10.1280.10; Di-copper center containing domain from catechol oxidase; 1. DR InterPro; IPR008922; Di-copper_centre_dom_sf. DR InterPro; IPR002049; LE_dom. DR InterPro; IPR050316; Tyrosinase/Hemocyanin. DR InterPro; IPR002227; Tyrosinase_Cu-bd. DR PANTHER; PTHR11474:SF124; TYROSINASE; 1. DR PANTHER; PTHR11474; TYROSINASE FAMILY MEMBER; 1. DR Pfam; PF00264; Tyrosinase; 1. DR SUPFAM; SSF48056; Di-copper centre-containing domain; 1. DR PROSITE; PS00497; TYROSINASE_1; 1. PE 3: Inferred from homology; KW Copper {ECO:0000256|ARBA:ARBA00023008}; KW Melanin biosynthesis {ECO:0000256|ARBA:ARBA00023101}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}. FT DOMAIN 143..160 FT /note="Tyrosinase copper-binding" FT /evidence="ECO:0000259|PROSITE:PS00497" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:ACL36639.1" FT NON_TER 173 FT /evidence="ECO:0000313|EMBL:ACL36639.1" SQ SEQUENCE 173 AA; 20173 MW; 2548AA01828E3CFB CRC64; VISNFPVGTQ FPFSGIDDRE NWPIVFYNRT CQCQGNFTGY HCGECKFGYT GPDCTIRRNL IRKEIFKMTT AEKDKFIAYL NLAKRTISPD YVISTGTYEQ MNNGSIPMFA DINVYDLFVW LHYYASRDAF VESGVWENID FAHEAPGFLP WHRLFLLIWE REIQKATGDE NFT //