ID   C0IZT5_9INFA            Unreviewed;       566 AA.
AC   C0IZT5;
DT   05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   05-MAY-2009, sequence version 1.
DT   05-OCT-2010, entry version 13.
DE   SubName: Full=Hemagglutinin;
GN   Name=HA;
OS   Influenza A virus (A/Guangdong/03/2005(H3N2)).
OC   Viruses; ssRNA negative-strand viruses; Orthomyxoviridae;
OC   Influenzavirus A.
OX   NCBI_TaxID=543833;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=A/Guangdong/03/2005;
RX   PubMed=19083267; DOI=10.1016/j.jcv.2008.10.011;
RA   Sun L., Zhang G., Shu Y., Chen X., Zhu Y., Yang L., Ma G.,
RA   Kitamura Y., Liu W.;
RT   "Genetic correlation between H3N2 human and swine influenza viruses.";
RL   J. Clin. Virol. 44:141-144(2009).
CC   -!- FUNCTION: Binds to sialic acid-containing receptors on the cell
CC       surface, bringing about the attachment of the virus particle to
CC       the cell. Plays a major role in the determination of host range
CC       restriction and virulence. Class I viral fusion protein.
CC       Responsible for penetration of the virus into the cell cytoplasm
CC       by mediating the fusion of the membrane of the endocytosed virus
CC       particle with the endosomal membrane. Low pH in endosomes induce
CC       an irreversible conformational change in HA2, releasing the fusion
CC       hydrophobic peptide. Several trimers are required to form a
CC       competent fusion pore (By similarity).
CC   -!- SUBUNIT: Homotrimer of disulfide-linked HA1-HA2 (By similarity).
CC   -!- SIMILARITY: Belongs to the influenza viruses hemagglutinin family.
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DR   EMBL; EU604298; ACF09402.1; -; Viral_cRNA.
DR   ProteinModelPortal; C0IZT5; -.
DR   SMR; C0IZT5; 25-518.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0046789; F:host cell surface receptor binding; IEA:InterPro.
DR   GO; GO:0019064; P:viral envelope fusion with host membrane; IEA:InterPro.
DR   InterPro; IPR008980; Capsid_hemagglutn.
DR   InterPro; IPR000149; Hemagglutn_influenz_A.
DR   InterPro; IPR001364; Hemagglutn_influenz_A/B.
DR   InterPro; IPR013829; Hemagglutn_stalk.
DR   Gene3D; G3DSA:3.90.20.10; Haemagglutn_stalk; 2.
DR   Pfam; PF00509; Hemagglutinin; 1.
DR   PRINTS; PR00330; HEMAGGLUTN1.
DR   PRINTS; PR00329; HEMAGGLUTN12.
DR   SUPFAM; SSF49818; Capsid_hemag; 1.
PE   3: Inferred from homology;
KW   Envelope protein; Fusion protein; Hemagglutinin; Host cell membrane;
KW   Host membrane; Membrane; Transmembrane; Transmembrane helix; Virion.
SQ   SEQUENCE   566 AA;  63581 MW;  C9715FC626A3AA28 CRC64;
     MKTIIALSYI LCLVFAQKLP GNDNSTATLC LGHHAVPNGT IVKTITNDQI EVTNATELVQ
     SSSTGGICDS PHQILDGENC TLIDALLGDP QCDGFQNKKW DLFVERSKAY SNCYPYDVPD
     YASLRSLVAS SGTLEFNNES FNWTGVTQNG TSSACKRRSN NSFFSRLNWL THLKFKYPAL
     NVTMPNNEKF DKLYIWGVHH PGTDNDQIFL YAQASGRITV STKRSQQTVI PNIGSRPRVR
     NIPSRISIYW TIVKPGDILL INSTGNLIAP RGYFKIRSGK SSIMRSDAPI GKCNSECITP
     NGSIPNDKPF QNVNRITYGA CPRYVKQNTL KLATGMRNVP EKQTRGIFGA IAGFIENGWE
     GMVDGWYGFR HQNSEGIGQA ADLKSTQAAI NQINGKLNRL IGKTNEKFHQ IEKEFSEVEG
     RIQDLEKYVE DTKIDLWSYN AELLVALENQ HTIDLTDSEM NKLFERTKKQ LRENAEDMGN
     GCFKIYHKCD NACIGSIRNG TYDHDVYRDE ALNNRFQIKG VELKSGYKDW ILWISFAISC
     FLLCVALLGF IMWACQKGNI RCNICI
//