ID PRS_GALME Reviewed; 20 AA. AC C0HLY5; DT 23-FEB-2022, integrated into UniProtKB/Swiss-Prot. DT 23-FEB-2022, sequence version 1. DT 25-MAY-2022, entry version 2. DE RecName: Full=Putative serine protease {ECO:0000303|PubMed:34443685}; DE EC=3.4.21.- {ECO:0000250|UniProtKB:Q9V3Z2}; DE Flags: Fragment; OS Galleria mellonella (Greater wax moth). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Pyraloidea; OC Pyralidae; Galleriinae; Galleria. OX NCBI_TaxID=7137; RN [1] {ECO:0000305} RP PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE. RX PubMed=34443685; DOI=10.3390/molecules26165097; RA Staczek S., Zdybicka-Barabas A., Wojda I., Wiater A., Mak P., Suder P., RA Skrzypiec K., Cytrynska M.; RT "Fungal alpha-1,3-Glucan as a New Pathogen-Associated Molecular Pattern in RT the Insect Model Host Galleria mellonella."; RL Molecules 26:5097-5097(2021). CC -!- FUNCTION: Binds the A.niger cell wall component alpha-1,3-glucan, a CC fungal pathogen-associated molecular pattern (PAMP) that activates the CC host immune response. {ECO:0000269|PubMed:34443685}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:34443685}. CC Note=Secreted in the hemolymph. {ECO:0000269|PubMed:34443685}. CC -!- DEVELOPMENTAL STAGE: Expressed in last instar larvae. CC {ECO:0000269|PubMed:34443685}. CC -!- SIMILARITY: Belongs to the peptidase S1 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR Proteomes; UP000504614; Unplaced. PE 1: Evidence at protein level; KW Direct protein sequencing; Hydrolase; Immunity; Innate immunity; Protease; KW Reference proteome; Secreted; Serine protease. FT CHAIN <1..>20 FT /note="Putative serine protease" FT /id="PRO_0000455046" FT NON_TER 1 FT /evidence="ECO:0000303|PubMed:34443685" FT NON_TER 20 FT /evidence="ECO:0000303|PubMed:34443685" SQ SEQUENCE 20 AA; 2258 MW; F3E99A15346D6C74 CRC64; LKDGPCPSYM DTCCLSPDRR //