ID SETD6_SALSA Reviewed; 449 AA. AC C0H8I2; DT 08-MAR-2011, integrated into UniProtKB/Swiss-Prot. DT 05-MAY-2009, sequence version 1. DT 11-MAY-2016, entry version 22. DE RecName: Full=N-lysine methyltransferase setd6; DE EC=2.1.1.-; DE AltName: Full=SET domain-containing protein 6; GN Name=setd6; OS Salmo salar (Atlantic salmon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; OC Salmoniformes; Salmonidae; Salmoninae; Salmo. OX NCBI_TaxID=8030; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=20433749; DOI=10.1186/1471-2164-11-279; RA Leong J.S., Jantzen S.G., von Schalburg K.R., Cooper G.A., RA Messmer A.M., Liao N.Y., Munro S., Moore R., Holt R.A., Jones S.J., RA Davidson W.S., Koop B.F.; RT "Salmo salar and Esox lucius full-length cDNA sequences reveal changes RT in evolutionary pressures on a post-tetraploidization genome."; RL BMC Genomics 11:279-279(2010). CC -!- FUNCTION: Protein-lysine N-methyltransferase. CC {ECO:0000250|UniProtKB:Q8TBK2}. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8TBK2}. CC -!- SIMILARITY: Belongs to the class V-like SAM-binding CC methyltransferase superfamily. Histone-lysine methyltransferase CC family. SETD6 subfamily. {ECO:0000255|PROSITE-ProRule:PRU00190}. CC -!- SIMILARITY: Contains 1 SET domain. {ECO:0000255|PROSITE- CC ProRule:PRU00190}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BT058638; ACN10351.1; -; mRNA. DR EMBL; BT060351; ACN12711.1; -; mRNA. DR RefSeq; NP_001158764.1; NM_001165292.1. DR UniGene; Ssa.27270; -. DR GeneID; 100306753; -. DR CTD; 79918; -. DR GO; GO:0005634; C:nucleus; ISS:UniProtKB. DR GO; GO:0016279; F:protein-lysine N-methyltransferase activity; ISS:UniProtKB. DR GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISS:UniProtKB. DR GO; GO:0018026; P:peptidyl-lysine monomethylation; ISS:UniProtKB. DR GO; GO:0050727; P:regulation of inflammatory response; ISS:UniProtKB. DR Gene3D; 3.90.1420.10; -; 1. DR InterPro; IPR011383; N-lys_methylase_SETD6. DR InterPro; IPR015353; Rubisco_LSMT_subst-bd. DR InterPro; IPR001214; SET_dom. DR Pfam; PF09273; Rubis-subs-bind; 1. DR Pfam; PF00856; SET; 1. DR PIRSF; PIRSF011771; RMS1_SET; 1. DR SUPFAM; SSF81822; SSF81822; 1. DR PROSITE; PS50280; SET; 1. PE 2: Evidence at transcript level; KW Methyltransferase; Nucleus; S-adenosyl-L-methionine; Transferase. FT CHAIN 1 449 N-lysine methyltransferase setd6. FT /FTId=PRO_0000405842. FT DOMAIN 32 257 SET. {ECO:0000255|PROSITE- FT ProRule:PRU00190}. SQ SEQUENCE 449 AA; 51445 MW; 558801AA0F4F1386 CRC64; MATDAKRLKT EGSDPLQSFL QWCEGVGLKL NNKVYISKEG TVAEYGMLAK EDIDEGELLF TIPRMALLHQ GTTKVLAVLE EGKASLENTS GWVPLLLALM YEYTSPQSHW RPYLSLWSDF TALDHPMFWS KDERDRLLKG TGIPEAVDTD LTNIQKEYKD IVLPFITLHP DLWDPERHTL DLYRSLVAFV MAYSFQEPLD EEDEDEKDPN PPMMVPIADM LNHVSNHNAN LEYTPECLKM VSVRSIRKGE EVFNTYGQMA NWQLLHMYGL XEPYQSNSND TADIPMSNVY KAAVQVTRSE AEQRLLVEKW SLLCEMEMVG DKGVFIFGKS GSLTDTEMYT TLKILCMSVE EFEDFRENEG WEEADDDEEK MLQALSNEGL PSLPPVWRCL VHAAARFTLD SYGEDMLKDK VLLEDKDGYA KLSSRQRRAL QVRYGQKTIL HQLLELTKP //