ID C0H4L5_PLAF7 Unreviewed; 92 AA. AC C0H4L5; DT 05-MAY-2009, integrated into UniProtKB/TrEMBL. DT 05-MAY-2009, sequence version 1. DT 12-AUG-2020, entry version 87. DE RecName: Full=Ribosomal protein L37 {ECO:0000256|RuleBase:RU000576}; GN ORFNames=PF3D7_0706400 {ECO:0000313|EMBL:CAX64035.1}; OS Plasmodium falciparum (isolate 3D7). OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; OC Plasmodiidae; Plasmodium; Plasmodium (Laverania). OX NCBI_TaxID=36329 {ECO:0000313|EMBL:CAX64035.1, ECO:0000313|Proteomes:UP000001450}; RN [1] {ECO:0000313|Proteomes:UP000001450} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450}; RX PubMed=12368864; DOI=10.1038/nature01097; RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W., RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D., RA Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S., RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M., RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A., RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I., RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J., RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.; RT "Genome sequence of the human malaria parasite Plasmodium falciparum."; RL Nature 419:498-511(2002). RN [2] {ECO:0000313|Proteomes:UP000001450} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450}; RX PubMed=12368867; DOI=10.1038/nature01095; RA Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D., RA Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K., RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T., RA Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M., RA Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A., RA Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H., RA Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D., RA Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N., RA Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P., RA Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A., RA Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., RA Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S., RA Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R., RA Sulston J.E., Craig A., Newbold C., Barrell B.G.; RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13."; RL Nature 419:527-531(2002). RN [3] {ECO:0000213|PDB:3J79} RP STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS) IN COMPLEX WITH ZINC. RX PubMed=24913268; DOI=10.7554/eLife.03080; RA Wong W., Bai X.C., Brown A., Fernandez I.S., Hanssen E., Condron M., RA Tan Y.H., Baum J., Scheres S.H.; RT "Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the RT anti-protozoan drug emetine."; RL Elife 3:e03080-e03080(2014). RN [4] {ECO:0000213|PDB:3JBN, ECO:0000213|PDB:3JBO, ECO:0000213|PDB:3JBP} RP STRUCTURE BY ELECTRON MICROSCOPY (4.70 ANGSTROMS) OF 2-90. RX PubMed=26432834; DOI=10.1093/nar/gkv991; RA Sun M., Li W., Blomqvist K., Das S., Hashem Y., Dvorin J.D., Frank J.; RT "Dynamical features of the Plasmodium falciparum ribosome during RT translation."; RL Nucleic Acids Res. 43:10515-10524(2015). RN [5] {ECO:0000213|PDB:5UMD} RP STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS). RX PubMed=28288098; DOI=10.1038/nmicrobiol.2017.31; RA Wong W., Bai X.C., Sleebs B.E., Triglia T., Brown A., Thompson J.K., RA Jackson K.E., Hanssen E., Marapana D.S., Fernandez I.S., Ralph S.A., RA Cowman A.F., Scheres S.H., Baum J.; RT "Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit RT protein synthesis."; RL Nat. Microbiol. 2:17031-17031(2017). CC -!- FUNCTION: Binds to the 23S rRNA. {ECO:0000256|RuleBase:RU000576}. CC -!- COFACTOR: CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105; CC Evidence={ECO:0000256|ARBA:ARBA00001947}; CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL37 family. CC {ECO:0000256|ARBA:ARBA00009805, ECO:0000256|RuleBase:RU000576}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL844506; CAX64035.1; -; Genomic_DNA. DR RefSeq; XP_002808762.1; XM_002808716.1. DR PDB; 3J79; EM; 3.20 A; c=1-92. DR PDB; 3JBN; EM; 4.70 A; Ac=2-90. DR PDB; 3JBO; EM; 5.80 A; Ac=2-90. DR PDB; 3JBP; EM; 6.70 A; Ac=2-90. DR PDB; 5UMD; EM; 3.20 A; c=1-92. DR PDBsum; 3J79; -. DR PDBsum; 3JBN; -. DR PDBsum; 3JBO; -. DR PDBsum; 3JBP; -. DR PDBsum; 5UMD; -. DR SMR; C0H4L5; -. DR PRIDE; C0H4L5; -. DR EnsemblProtists; CAX64035; CAX64035; PF3D7_0706400. DR GeneDB; PF3D7_0706400.1:pep; -. DR GeneID; 9221880; -. DR KEGG; pfa:PF3D7_0706400; -. DR EuPathDB; PlasmoDB:PF3D7_0706400; -. DR HOGENOM; CLU_150908_0_0_1; -. DR InParanoid; C0H4L5; -. DR KO; K02922; -. DR OMA; RMAYLKH; -. DR PhylomeDB; C0H4L5; -. DR BioCyc; PLASMO:MAL7P1.320-MONOMER; -. DR Reactome; R-PFA-156827; L13a-mediated translational silencing of Ceruloplasmin expression. DR Reactome; R-PFA-1799339; SRP-dependent cotranslational protein targeting to membrane. DR Reactome; R-PFA-72689; Formation of a pool of free 40S subunits. DR Reactome; R-PFA-72706; GTP hydrolysis and joining of the 60S ribosomal subunit. DR Reactome; R-PFA-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC). DR Reactome; R-PFA-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC). DR Proteomes; UP000001450; Chromosome 7. DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IDA:GeneDB. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0003723; F:RNA binding; IBA:GO_Central. DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW. DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro. DR GO; GO:0006412; P:translation; IEA:InterPro. DR Gene3D; 2.20.25.30; -; 1. DR HAMAP; MF_00547; Ribosomal_L37e; 1. DR InterPro; IPR011331; Ribosomal_L37ae/L37e. DR InterPro; IPR001569; Ribosomal_L37e. DR InterPro; IPR018267; Ribosomal_L37e_CS. DR InterPro; IPR011332; Ribosomal_zn-bd. DR Pfam; PF01907; Ribosomal_L37e; 1. DR SUPFAM; SSF57829; SSF57829; 1. DR PROSITE; PS01077; RIBOSOMAL_L37E; 1. PE 1: Evidence at protein level; KW 3D-structure {ECO:0000213|PDB:3J79, ECO:0000213|PDB:3JBN, KW ECO:0000213|PDB:3JBO, ECO:0000213|PDB:3JBP}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, KW ECO:0000256|RuleBase:RU000576}; KW Reference proteome {ECO:0000313|Proteomes:UP000001450}; KW Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274, KW ECO:0000256|RuleBase:RU000576}; KW Ribosomal protein {ECO:0000256|ARBA:ARBA00022980, KW ECO:0000256|RuleBase:RU000576, ECO:0000313|EMBL:CAX64035.1}; KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|RuleBase:RU000576}; KW rRNA-binding {ECO:0000256|ARBA:ARBA00022730, KW ECO:0000256|RuleBase:RU000576}; KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU000576}; KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}. SQ SEQUENCE 92 AA; 10539 MW; 3DDAB7E1865F1034 CRC64; MGKAGKGTGS FGKRNGKTHF LCLRCGKRSY HLQKKKCASC GYPSAKKRRF NWSVKAKRRN TTGTGRCRYI KTLRRKLKNK FTEGSTPKPK QR //