ID B8ZN14_STRPJ Unreviewed; 260 AA. AC B8ZN14; DT 03-MAR-2009, integrated into UniProtKB/TrEMBL. DT 03-MAR-2009, sequence version 1. DT 16-JUN-2009, entry version 4. DE SubName: Full=Hydroxyethylthiazole kinase; DE EC=2.7.1.50; GN Name=thiM; OrderedLocusNames=SPN23F06420; OS Streptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1). OC Bacteria; Firmicutes; Lactobacillales; Streptococcaceae; OC Streptococcus. OX NCBI_TaxID=561276; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=19114491; DOI=10.1128/JB.01343-08; RA Croucher N.J., Walker D., Romero P., Lennard N., Paterson G.K., RA Bason N.C., Mitchell A.M., Quail M.A., Andrew P.W., Parkhill J., RA Bentley S.D., Mitchell T.J.; RT "Role of conjugative elements in the evolution of the multidrug- RT resistant pandemic clone Streptococcus pneumoniae Spain23F ST81."; RL J. Bacteriol. 191:1480-1489(2009). CC -!- CATALYTIC ACTIVITY: ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = CC ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. CC -!- PATHWAY: Cofactor biosynthesis; thiamine pyrophosphate CC biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 4-methyl- CC 5-(2-hydroxyethyl)-thiazole: step 1/1. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; FM211187; CAR68489.1; -; Genomic_DNA. DR RefSeq; YP_002510671.1; -. DR GeneID; 7328265; -. DR GenomeReviews; FM211187_GR; SPN23F06420. DR InterPro; IPR000417; Hyethyz_kinase. DR InterPro; IPR011144; Hyethyz_kinsmonf. DR PANTHER; PTHR20857:SF14; Hyethyz_kinase; 1. DR Pfam; PF02110; HK; 1. DR PIRSF; PIRSF000513; Thz_kinase; 1. DR PRINTS; PR01099; HYETHTZKNASE. DR TIGRFAMs; TIGR00694; thiM; 1. PE 4: Predicted; KW ATP-binding; Complete proteome; Kinase; Nucleotide-binding; KW Thiamine biosynthesis; Transferase. SQ SEQUENCE 260 AA; 27635 MW; B1846DA024C97404 CRC64; MTSLKLLKEK APLVICITND VVKNFTANGL VALGASPAMS EFPADLEDLL KYAGGLLINI GTLTDENWKL YQAALKIAEK YNVPVVLDPV ACGAGEYRKK VADDLINNYK LAAIRGNAGE IASLVGIDVA SKGVDSAGVD NIDEIALAAN EKFNIPIVVT GEVDAIAVNG EVVTIHNGSA MMPKVIGTGC LLGAVVASFI GLEKGQELKS LETAMLVYNI AGEMAEKRPN GHLPGTFKVE FINALYEITD EDVKEFKRVK //