ID B8YP89_MOUSE Unreviewed; 106 AA. AC B8YP89; DT 03-MAR-2009, integrated into UniProtKB/TrEMBL. DT 03-MAR-2009, sequence version 1. DT 02-OCT-2024, entry version 80. DE SubName: Full=Parkin RBR E3 ubiquitin protein ligase {ECO:0000313|Ensembl:ENSMUSP00000156481.2}; DE SubName: Full=Truncated parkin variant SV3DEL {ECO:0000313|EMBL:ACL93282.1}; DE EC=6.3.2.19 {ECO:0000313|EMBL:ACL93282.1}; GN Name=Prkn {ECO:0000313|Ensembl:ENSMUSP00000156481.2, GN ECO:0000313|MGI:MGI:1355296}; GN Synonyms=Park2 {ECO:0000313|EMBL:ACL93282.1}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:ACL93282.1}; RN [1] {ECO:0000313|EMBL:ACL93282.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:ACL93282.1}; RC TISSUE=Retina {ECO:0000313|EMBL:ACL93282.1}; RA Campello L., Esteve-Rudd J., Cuenca N., Martin-Nieto J.; RL Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSMUSP00000156481.2, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000156481.2, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RG Mouse Genome Sequencing Consortium; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000156481.2} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000156481.2}; RX PubMed=21750661; RA Church D.M., Schneider V.A., Graves T., Auger K., Cunningham F., Bouk N., RA Chen H.C., Agarwala R., McLaren W.M., Ritchie G.R., Albracht D., RA Kremitzki M., Rock S., Kotkiewicz H., Kremitzki C., Wollam A., Trani L., RA Fulton L., Fulton R., Matthews L., Whitehead S., Chow W., Torrance J., RA Dunn M., Harden G., Threadgold G., Wood J., Collins J., Heath P., RA Griffiths G., Pelan S., Grafham D., Eichler E.E., Weinstock G., RA Mardis E.R., Wilson R.K., Howe K., Flicek P., Hubbard T.; RT "Modernizing reference genome assemblies."; RL PLoS Biol. 9:e1001091-e1001091(2011). RN [4] {ECO:0000313|Ensembl:ENSMUSP00000156481.2} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000156481.2}; RG Ensembl; RL Submitted (JUN-2024) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; FJ555556; ACL93282.1; -; mRNA. DR Antibodypedia; 4264; 871 antibodies from 51 providers. DR Ensembl; ENSMUST00000233634.2; ENSMUSP00000156481.2; ENSMUSG00000023826.18. DR AGR; MGI:1355296; -. DR MGI; MGI:1355296; Prkn. DR VEuPathDB; HostDB:ENSMUSG00000023826; -. DR GeneTree; ENSGT00390000011034; -. DR ChiTaRS; Prkn; mouse. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000023826; Expressed in hindlimb stylopod muscle and 110 other cell types or tissues. DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW. DR InterPro; IPR015496; Ubiquilin. DR InterPro; IPR000626; Ubiquitin-like_dom. DR InterPro; IPR029071; Ubiquitin-like_domsf. DR PANTHER; PTHR10677; UBIQUILIN; 1. DR PANTHER; PTHR10677:SF40; UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN; 1. DR Pfam; PF00240; ubiquitin; 1. DR SMART; SM00213; UBQ; 1. DR SUPFAM; SSF54236; Ubiquitin-like; 1. DR PROSITE; PS50053; UBIQUITIN_2; 1. PE 2: Evidence at transcript level; KW Ligase {ECO:0000313|EMBL:ACL93282.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}. FT DOMAIN 1..60 FT /note="Ubiquitin-like" FT /evidence="ECO:0000259|PROSITE:PS50053" FT REGION 59..106 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 59..89 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 106 AA; 11482 MW; DD6C3D34D2C3BDF2 CRC64; MIVFVRFNSS YGFPVEVDSD TSILQLKEVV AKRQGVPADQ LRVIFAGKEL PNHLTVQQLN PPTTAFSSTA KAPATRSSLE SSEFSVAPAN KQPSPWPRAH LAGTMS //