ID B8YP89_MOUSE Unreviewed; 106 AA. AC B8YP89; DT 03-MAR-2009, integrated into UniProtKB/TrEMBL. DT 03-MAR-2009, sequence version 1. DT 14-OCT-2015, entry version 37. DE SubName: Full=Truncated parkin variant SV3DEL {ECO:0000313|EMBL:ACL93282.1}; DE EC=6.3.2.19 {ECO:0000313|EMBL:ACL93282.1}; GN Name=Park2 {ECO:0000313|EMBL:ACL93282.1, ECO:0000313|MGI:MGI:1355296}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:ACL93282.1}; RN [1] {ECO:0000313|EMBL:ACL93282.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:ACL93282.1}; RC TISSUE=Retina {ECO:0000313|EMBL:ACL93282.1}; RA Campello L., Esteve-Rudd J., Cuenca N., Martin-Nieto J.; RL Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; FJ555556; ACL93282.1; -; mRNA. DR UniGene; Mm.311110; -. DR ProteinModelPortal; B8YP89; -. DR MGI; MGI:1355296; Park2. DR NextBio; 35547923; -. DR GO; GO:0016235; C:aggresome; ISO:MGI. DR GO; GO:0005737; C:cytoplasm; IDA:MGI. DR GO; GO:0005829; C:cytosol; ISO:MGI. DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI. DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI. DR GO; GO:0005739; C:mitochondrion; ISO:MGI. DR GO; GO:0043005; C:neuron projection; IDA:MGI. DR GO; GO:0005634; C:nucleus; IDA:MGI. DR GO; GO:1990452; C:Parkin-FBXW7-Cul1 ubiquitin ligase complex; ISO:MGI. DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:MGI. DR GO; GO:0043234; C:protein complex; IDA:MGI. DR GO; GO:0000151; C:ubiquitin ligase complex; ISO:MGI. DR GO; GO:0003779; F:actin binding; ISO:MGI. DR GO; GO:0051087; F:chaperone binding; ISO:MGI. DR GO; GO:0097602; F:cullin family protein binding; ISO:MGI. DR GO; GO:0019899; F:enzyme binding; ISO:MGI. DR GO; GO:1990444; F:F-box domain binding; ISO:MGI. DR GO; GO:0001664; F:G-protein coupled receptor binding; ISO:MGI. DR GO; GO:0031072; F:heat shock protein binding; ISO:MGI. DR GO; GO:0042826; F:histone deacetylase binding; ISO:MGI. DR GO; GO:0030544; F:Hsp70 protein binding; ISO:MGI. DR GO; GO:0042802; F:identical protein binding; ISO:MGI. DR GO; GO:0019900; F:kinase binding; ISO:MGI. DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW. DR GO; GO:0030165; F:PDZ domain binding; ISO:MGI. DR GO; GO:0043274; F:phospholipase binding; ISO:MGI. DR GO; GO:0019901; F:protein kinase binding; ISO:MGI. DR GO; GO:0015631; F:tubulin binding; ISO:MGI. DR GO; GO:0043130; F:ubiquitin binding; ISO:MGI. DR GO; GO:0031624; F:ubiquitin conjugating enzyme binding; ISO:MGI. DR GO; GO:0061630; F:ubiquitin protein ligase activity; IDA:MGI. DR GO; GO:0031625; F:ubiquitin protein ligase binding; ISO:MGI. DR GO; GO:0004842; F:ubiquitin-protein transferase activity; ISO:MGI. DR GO; GO:1990381; F:ubiquitin-specific protease binding; ISO:MGI. DR GO; GO:0098779; P:activation of mitophagy in response to mitochondrial depolarization; ISO:MGI. DR GO; GO:0008344; P:adult locomotory behavior; IMP:MGI. DR GO; GO:0070842; P:aggresome assembly; ISO:MGI. DR GO; GO:0044257; P:cellular protein catabolic process; ISO:MGI. DR GO; GO:0097237; P:cellular response to toxic substance; ISO:MGI. DR GO; GO:0042417; P:dopamine metabolic process; IMP:MGI. DR GO; GO:0051583; P:dopamine uptake involved in synaptic transmission; IMP:MGI. DR GO; GO:0007612; P:learning; IMP:MGI. DR GO; GO:0007626; P:locomotory behavior; IMP:MGI. DR GO; GO:0000422; P:mitophagy; ISO:MGI. DR GO; GO:0050804; P:modulation of synaptic transmission; IMP:MGI. DR GO; GO:0044828; P:negative regulation by host of viral genome replication; ISO:MGI. DR GO; GO:0032232; P:negative regulation of actin filament bundle assembly; ISO:MGI. DR GO; GO:0060548; P:negative regulation of cell death; ISO:MGI. DR GO; GO:1902236; P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; ISO:MGI. DR GO; GO:0010629; P:negative regulation of gene expression; ISO:MGI. DR GO; GO:0033132; P:negative regulation of glucokinase activity; ISO:MGI. DR GO; GO:0046676; P:negative regulation of insulin secretion; ISO:MGI. DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; ISO:MGI. DR GO; GO:1901215; P:negative regulation of neuron death; ISO:MGI. DR GO; GO:1903377; P:negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; ISO:MGI. DR GO; GO:1902283; P:negative regulation of primary amine oxidase activity; ISO:MGI. DR GO; GO:0001933; P:negative regulation of protein phosphorylation; ISO:MGI. DR GO; GO:2000378; P:negative regulation of reactive oxygen species metabolic process; ISO:MGI. DR GO; GO:0090201; P:negative regulation of release of cytochrome c from mitochondria; ISO:MGI. DR GO; GO:1904049; P:negative regulation of spontaneous neurotransmitter secretion; ISO:MGI. DR GO; GO:0042415; P:norepinephrine metabolic process; IMP:MGI. DR GO; GO:0043388; P:positive regulation of DNA binding; ISO:MGI. DR GO; GO:0010628; P:positive regulation of gene expression; ISO:MGI. DR GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; ISO:MGI. DR GO; GO:0010636; P:positive regulation of mitochondrial fusion; ISO:MGI. DR GO; GO:0051582; P:positive regulation of neurotransmitter uptake; ISO:MGI. DR GO; GO:1901800; P:positive regulation of proteasomal protein catabolic process; ISO:MGI. DR GO; GO:1902530; P:positive regulation of protein linear polyubiquitination; ISO:MGI. DR GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISO:MGI. DR GO; GO:1903265; P:positive regulation of tumor necrosis factor-mediated signaling pathway; ISO:MGI. DR GO; GO:0010498; P:proteasomal protein catabolic process; ISO:MGI. DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; ISO:MGI. DR GO; GO:0051865; P:protein autoubiquitination; ISO:MGI. DR GO; GO:0070979; P:protein K11-linked ubiquitination; ISO:MGI. DR GO; GO:0070936; P:protein K48-linked ubiquitination; ISO:MGI. DR GO; GO:0085020; P:protein K6-linked ubiquitination; ISO:MGI. DR GO; GO:0070534; P:protein K63-linked ubiquitination; ISO:MGI. DR GO; GO:0019538; P:protein metabolic process; IMP:MGI. DR GO; GO:0006513; P:protein monoubiquitination; ISO:MGI. DR GO; GO:0000209; P:protein polyubiquitination; ISO:MGI. DR GO; GO:0050821; P:protein stabilization; ISO:MGI. DR GO; GO:0016567; P:protein ubiquitination; ISO:MGI. DR GO; GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ISO:MGI. DR GO; GO:0010506; P:regulation of autophagy; ISO:MGI. DR GO; GO:1900407; P:regulation of cellular response to oxidative stress; ISO:MGI. DR GO; GO:0042053; P:regulation of dopamine metabolic process; ISO:MGI. DR GO; GO:0010821; P:regulation of mitochondrion organization; ISO:MGI. DR GO; GO:0046928; P:regulation of neurotransmitter secretion; IMP:MGI. DR GO; GO:0031396; P:regulation of protein ubiquitination; ISO:MGI. DR GO; GO:2000377; P:regulation of reactive oxygen species metabolic process; ISO:MGI. DR GO; GO:0034976; P:response to endoplasmic reticulum stress; ISO:MGI. DR GO; GO:0001964; P:startle response; IMP:MGI. DR GO; GO:0001963; P:synaptic transmission, dopaminergic; IMP:MGI. DR GO; GO:0035249; P:synaptic transmission, glutamatergic; IMP:MGI. DR InterPro; IPR031127; E3_UB_ligase_RBR. DR InterPro; IPR029071; Ubiquitin-rel_dom. DR InterPro; IPR000626; Ubiquitin_dom. DR PANTHER; PTHR11685; PTHR11685; 1. DR Pfam; PF00240; ubiquitin; 1. DR SMART; SM00213; UBQ; 1. DR SUPFAM; SSF54236; SSF54236; 1. DR PROSITE; PS50053; UBIQUITIN_2; 1. PE 2: Evidence at transcript level; KW Ligase {ECO:0000313|EMBL:ACL93282.1}. SQ SEQUENCE 106 AA; 11482 MW; DD6C3D34D2C3BDF2 CRC64; MIVFVRFNSS YGFPVEVDSD TSILQLKEVV AKRQGVPADQ LRVIFAGKEL PNHLTVQQLN PPTTAFSSTA KAPATRSSLE SSEFSVAPAN KQPSPWPRAH LAGTMS //