ID B8K2Q5_HUMAN Unreviewed; 115 AA. AC B8K2Q5; DT 03-MAR-2009, integrated into UniProtKB/TrEMBL. DT 03-MAR-2009, sequence version 1. DT 24-JAN-2024, entry version 76. DE SubName: Full=Mu opioid receptor splice variant MOR-1H {ECO:0000313|EMBL:ABH03503.1}; DE Flags: Fragment; GN Name=OPRM1 {ECO:0000313|EMBL:ABH03503.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:ABH03503.1}; RN [1] {ECO:0000313|EMBL:ABH03503.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=19077058; DOI=10.1111/j.1471-4159.2008.05833.x; RA Xu J., Xu M., Hurd Y.L., Pasternak G.W., Pan Y.X.; RT "Isolation and characterization of new exon 11-associated N-terminal splice RT variants of the human mu opioid receptor gene."; RL J. Neurochem. 108:962-972(2009). CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Endosome CC {ECO:0000256|ARBA:ARBA00004177}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ680044; ABH03503.1; -; mRNA. DR RefSeq; NP_001138751.1; NM_001145279.3. DR RefSeq; NP_001138752.1; NM_001145280.3. DR RefSeq; NP_001138753.1; NM_001145281.2. DR AlphaFoldDB; B8K2Q5; -. DR DNASU; 4988; -. DR GeneID; 4988; -. DR CTD; 4988; -. DR OrthoDB; 5393360at2759; -. DR BioGRID-ORCS; 4988; 11 hits in 1151 CRISPR screens. DR ChiTaRS; OPRM1; human. DR GenomeRNAi; 4988; -. DR Genevisible; B8K2Q5; HS. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0004979; F:beta-endorphin receptor activity; IEA:InterPro. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR000105; Mu_opioid_rcpt. DR PANTHER; PTHR24229:SF7; MU-TYPE OPIOID RECEPTOR; 1. DR PANTHER; PTHR24229; NEUROPEPTIDES RECEPTOR; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00537; MUOPIOIDR. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 2: Evidence at transcript level; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:ABH03503.1}; KW Transducer {ECO:0000256|ARBA:ARBA00023224}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 67..96 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 87..115 FT /note="G-protein coupled receptors family 1 profile" FT /evidence="ECO:0000259|PROSITE:PS50262" FT NON_TER 115 FT /evidence="ECO:0000313|EMBL:ABH03503.1" SQ SEQUENCE 115 AA; 12071 MW; 6D2E8AE9EF7C1C6C CRC64; MDSSAAPTNA SNCTDALAYS SCSPAPSPGS WVNLSHLDGN LSDPCGPNRT DLGGRDSLCP PTGSPSMITA ITIMALYSIV CVVGLFGNFL VMYVIVRYTK MKTATNIYIF NLALA //