ID B8K2Q5_HUMAN Unreviewed; 115 AA. AC B8K2Q5; DT 03-MAR-2009, integrated into UniProtKB/TrEMBL. DT 03-MAR-2009, sequence version 1. DT 07-JAN-2015, entry version 42. DE SubName: Full=Mu opioid receptor splice variant MOR-1H {ECO:0000313|EMBL:ABH03503.1}; DE Flags: Fragment; GN Name=OPRM1 {ECO:0000313|EMBL:ABH03503.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:ABH03503.1}; RN [1] {ECO:0000313|EMBL:ABH03503.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=19077058; DOI=10.1111/j.1471-4159.2008.05833.x; RA Xu J., Xu M., Hurd Y.L., Pasternak G.W., Pan Y.X.; RT "Isolation and characterization of new exon 11-associated N-terminal RT splice variants of the human mu opioid receptor gene."; RL J. Neurochem. 108:962-972(2009). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ680044; ABH03503.1; -; mRNA. DR RefSeq; NP_001138751.1; NM_001145279.3. DR RefSeq; NP_001138752.1; NM_001145280.3. DR RefSeq; NP_001138753.1; NM_001145281.2. DR UniGene; Hs.2353; -. DR ProteinModelPortal; B8K2Q5; -. DR BindingDB; B8K2Q5; -. DR GeneID; 4988; -. DR KEGG; hsa:4988; -. DR CTD; 4988; -. DR HOVERGEN; HBG079754; -. DR KO; K04215; -. DR GenomeRNAi; 4988; -. DR NextBio; 19206; -. DR Bgee; B8K2Q5; -. DR ExpressionAtlas; B8K2Q5; baseline and differential. DR GO; GO:0032839; C:dendrite cytoplasm; IEA:Ensembl. DR GO; GO:0032590; C:dendrite membrane; IEA:Ensembl. DR GO; GO:0005925; C:focal adhesion; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:InterPro. DR GO; GO:0045121; C:membrane raft; IEA:Ensembl. DR GO; GO:0043204; C:perikaryon; IEA:Ensembl. DR GO; GO:0042383; C:sarcolemma; IEA:Ensembl. DR GO; GO:0004979; F:beta-endorphin receptor activity; IEA:InterPro. DR GO; GO:0038047; F:morphine receptor activity; IEA:Ensembl. DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:Ensembl. DR GO; GO:0002438; P:acute inflammatory response to antigenic stimulus; IEA:Ensembl. DR GO; GO:0007191; P:adenylate cyclase-activating dopamine receptor signaling pathway; IEA:Ensembl. DR GO; GO:0031635; P:adenylate cyclase-inhibiting opioid receptor signaling pathway; IEA:Ensembl. DR GO; GO:0007626; P:locomotory behavior; IEA:Ensembl. DR GO; GO:0007194; P:negative regulation of adenylate cyclase activity; IEA:Ensembl. DR GO; GO:0007200; P:phospholipase C-activating G-protein coupled receptor signaling pathway; IEA:Ensembl. DR GO; GO:0032100; P:positive regulation of appetite; IEA:Ensembl. DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl. DR GO; GO:0050769; P:positive regulation of neurogenesis; IEA:Ensembl. DR GO; GO:0060079; P:regulation of excitatory postsynaptic membrane potential; IEA:Ensembl. DR GO; GO:2000310; P:regulation of N-methyl-D-aspartate selective glutamate receptor activity; IEA:Ensembl. DR GO; GO:0051930; P:regulation of sensory perception of pain; IEA:Ensembl. DR GO; GO:0042220; P:response to cocaine; IEA:Ensembl. DR GO; GO:0032094; P:response to food; IEA:Ensembl. DR GO; GO:0070848; P:response to growth factor; IEA:Ensembl. DR GO; GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl. DR GO; GO:0019233; P:sensory perception of pain; IEA:Ensembl. DR GO; GO:0042060; P:wound healing; IEA:Ensembl. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR000105; Mu_opioid_rcpt. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00537; MUOPIOIDR. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 2: Evidence at transcript level; KW Receptor {ECO:0000313|EMBL:ABH03503.1}. FT NON_TER 115 115 {ECO:0000313|EMBL:ABH03503.1}. SQ SEQUENCE 115 AA; 12071 MW; 6D2E8AE9EF7C1C6C CRC64; MDSSAAPTNA SNCTDALAYS SCSPAPSPGS WVNLSHLDGN LSDPCGPNRT DLGGRDSLCP PTGSPSMITA ITIMALYSIV CVVGLFGNFL VMYVIVRYTK MKTATNIYIF NLALA //