ID DNLI_ANAD2 Reviewed; 513 AA. AC B8JBM1; DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot. DT 03-MAR-2009, sequence version 1. DT 19-JAN-2010, entry version 9. DE RecName: Full=Probable DNA ligase; DE EC=6.5.1.1; DE AltName: Full=Polydeoxyribonucleotide synthase [ATP]; GN Name=lig; OrderedLocusNames=A2cp1_4312; OS Anaeromyxobacter dehalogenans (strain 2CP-1 / ATCC BAA-258). OC Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales; OC Cystobacterineae; Myxococcaceae; Anaeromyxobacter. OX NCBI_TaxID=455488; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., RA Tice H., Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., RA Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., RA Ovchinnikova G., Beliaev A.S., Richardson P.; RT "Complete sequence of Anaeromyxobacter dehalogenans 2CP-1."; RL Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: DNA ligase that seals nicks in double-stranded DNA CC during DNA replication, DNA recombination and DNA repair (By CC similarity). CC -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n) + CC (deoxyribonucleotide)(m) = AMP + diphosphate + CC (deoxyribonucleotide)(n+m). CC -!- COFACTOR: Divalent metal cations (By similarity). CC -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP001359; ACL67629.1; -; Genomic_DNA. DR RefSeq; YP_002494695.1; -. DR SMR; B8JBM1; 1-512. DR GeneID; 7298387; -. DR GenomeReviews; CP001359_GR; A2cp1_4312. DR KEGG; acp:A2cp1_4312; -. DR HOGENOM; HBG570821; -. DR GO; GO:0005524; F:ATP binding; IEA:HAMAP. DR GO; GO:0003677; F:DNA binding; IEA:InterPro. DR GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:HAMAP. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW. DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW. DR GO; GO:0006310; P:DNA recombination; IEA:HAMAP. DR GO; GO:0006281; P:DNA repair; IEA:HAMAP. DR GO; GO:0006260; P:DNA replication; IEA:HAMAP. DR HAMAP; MF_00407; DNA_ligase; 1; -. DR InterPro; IPR000977; DNA_ligase. DR InterPro; IPR012309; DNA_ligase_A_C. DR InterPro; IPR012310; DNA_ligase_A_M. DR InterPro; IPR012308; DNA_ligase_A_N. DR InterPro; IPR016059; DNA_ligase_CS. DR InterPro; IPR012340; NA-bd_OB-fold. DR Gene3D; G3DSA:2.40.50.140; OB_NA_bd_sub; 1. DR Pfam; PF04679; DNA_ligase_A_C; 1. DR Pfam; PF01068; DNA_ligase_A_M; 1. DR Pfam; PF04675; DNA_ligase_A_N; 1. DR PROSITE; PS00697; DNA_LIGASE_A1; 1. DR PROSITE; PS00333; DNA_LIGASE_A2; 1. DR PROSITE; PS50160; DNA_LIGASE_A3; 1. PE 3: Inferred from homology; KW ATP-binding; Cell cycle; Cell division; Complete proteome; DNA damage; KW DNA recombination; DNA repair; DNA replication; Ligase; Metal-binding; KW Nucleotide-binding. FT CHAIN 1 513 Probable DNA ligase. FT /FTId=PRO_1000134725. FT ACT_SITE 215 215 N6-AMP-lysine intermediate (By FT similarity). FT BINDING 213 213 ATP (By similarity). FT BINDING 220 220 ATP (By similarity). FT BINDING 235 235 ATP (By similarity). FT BINDING 264 264 ATP (By similarity). FT BINDING 304 304 ATP (By similarity). FT BINDING 376 376 ATP (By similarity). FT BINDING 382 382 ATP (By similarity). SQ SEQUENCE 513 AA; 54060 MW; A4CCC38389CAB126 CRC64; MLLAELAEVS RAVAATPARL EKIARLAEAL RRLAPDERAV GASWLAGDLP GGRIGIGGAT VRAALDAAPA EGGGPGLTVA EVDAALGRIA TASGAGSAGA RRRELDALLA RAGAPERWFL AALLLGELRQ GALEGVLADA VARAAGLPAA EVRRAAMLAG ALPPVAVAAL SEGAAGLARF RLRVGEPVSP MLAQTAADVE EALRALGGEA ALEWKLDGAR IQAHRDGGEV RVFSRSLRDV TAAVPEVVAL LRAAPEPRLV LDGEAIALRA DGTPEPFQVT MRRFGRRLDV ERLAPDLPLT AFFFDALVAG GAELLASPER VRWAALERAV PAEQRVPRLV TRDPAEAGAF LEDALARGQE GVVAKALDAP YEAGRRGAAW LKVKRAHTLD LVVLAAEWGS GRRRGWLSNL HLGARDPSTG GFVMLGKTFK GMTDAMLAWQ TERLKALATG PLDAWQVPVR PELVVEVAFD GIQSSPRYPG GLALRFARVK RYREDKRPED ADTIETVRGL YGG //