ID B8JAR2_ANAD2 Unreviewed; 122 AA. AC B8JAR2; DT 03-MAR-2009, integrated into UniProtKB/TrEMBL. DT 03-MAR-2009, sequence version 1. DT 16-JUN-2009, entry version 3. DE SubName: Full=7-cyano-7-deazaguanine reductase; GN OrderedLocusNames=A2cp1_4244; OS Anaeromyxobacter dehalogenans (strain 2CP-1 / ATCC BAA-258). OC Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales; OC Cystobacterineae; Myxococcaceae; Anaeromyxobacter. OX NCBI_TaxID=455488; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., RA Tice H., Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., RA Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., RA Ovchinnikova G., Beliaev A.S., Richardson P.; RT "Complete sequence of Anaeromyxobacter dehalogenans 2CP-1."; RL Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Catalyzes the NADPH-dependent reduction of 7-cyano-7- CC deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By CC similarity). CC -!- CATALYTIC ACTIVITY: 7-aminomethyl-7-carbaguanine + 2 NADP(+) = 7- CC cyano-7-carbaguanine + 2 NADPH. CC -!- PATHWAY: tRNA modification; queuosine-tRNA biosynthesis. CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP001359; ACL67561.1; -; Genomic_DNA. DR RefSeq; YP_002494627.1; -. DR GeneID; 7298319; -. DR GenomeReviews; CP001359_GR; A2cp1_4244. DR InterPro; IPR016856; CN_OxRdtase_NADPH-dep_QueF. DR InterPro; IPR001474; GTP_CycHdrlase_I. DR Pfam; PF01227; GTP_cyclohydroI; 1. DR PIRSF; PIRSF027377; Nitrile_oxidored_QueF; 1. DR TIGRFAMs; TIGR03139; QueF-II; 1. PE 3: Inferred from homology; KW Complete proteome; Cytoplasm; NADP; Oxidoreductase; KW Queuosine biosynthesis. SQ SEQUENCE 122 AA; 13700 MW; 01C81A29DCFD9678 CRC64; MPTQPSRDLQ TFPNPKPGRP FEIAMECPEF TCVCPMTGQP DFATIRLRYV PAERCVELKS LKLYLWSFRN EGTFHEAVTN RICDDLVAAL APRWIEVVGD FAVRGGIHTV VTARHGERPA GV //