ID QUEF_ANAD2 Reviewed; 122 AA. AC B8JAR2; DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot. DT 03-MAR-2009, sequence version 1. DT 27-JUL-2011, entry version 17. DE RecName: Full=NADPH-dependent 7-cyano-7-deazaguanine reductase; DE EC=1.7.1.13; DE AltName: Full=7-cyano-7-carbaguanine reductase; DE AltName: Full=NADPH-dependent nitrile oxidoreductase; DE AltName: Full=PreQ(0) reductase; GN Name=queF; OrderedLocusNames=A2cp1_4244; OS Anaeromyxobacter dehalogenans (strain 2CP-1 / ATCC BAA-258). OC Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales; OC Cystobacterineae; Myxococcaceae; Anaeromyxobacter. OX NCBI_TaxID=455488; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=2CP-1 / ATCC BAA-258; RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., RA Tice H., Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., RA Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., RA Ovchinnikova G., Beliaev A.S., Richardson P.; RT "Complete sequence of Anaeromyxobacter dehalogenans 2CP-1."; RL Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Catalyzes the NADPH-dependent reduction of 7-cyano-7- CC deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By CC similarity). CC -!- CATALYTIC ACTIVITY: 7-aminomethyl-7-carbaguanine + 2 NADP(+) = 7- CC cyano-7-carbaguanine + 2 NADPH. CC -!- PATHWAY: tRNA modification; tRNA-queuosine biosynthesis. CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). CC -!- SIMILARITY: Belongs to the GTP cyclohydrolase I family. QueF type CC 1 subfamily. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP001359; ACL67561.1; -; Genomic_DNA. DR RefSeq; YP_002494627.1; NC_011891.1. DR ProteinModelPortal; B8JAR2; -. DR SMR; B8JAR2; 32-110. DR STRING; B8JAR2; -. DR GeneID; 7298319; -. DR GenomeReviews; CP001359_GR; A2cp1_4244. DR KEGG; acp:A2cp1_4244; -. DR HOGENOM; HBG294103; -. DR ProtClustDB; PRK13258; -. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0046857; F:oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor; IEA:InterPro. DR GO; GO:0033739; F:preQ1 synthase activity; IEA:EC. DR GO; GO:0008616; P:queuosine biosynthetic process; IEA:UniProtKB-KW. DR HAMAP; MF_00818; QueF_type1; 1; -. DR InterPro; IPR016856; CN_OxRdtase_NADPH-dep_QueF. DR InterPro; IPR020602; GTP_CycHdrlase_I/CN_OxRdtase. DR Pfam; PF01227; GTP_cyclohydroI; 1. DR PIRSF; PIRSF027377; Nitrile_oxidored_QueF; 1. DR TIGRFAMs; TIGR03139; QueF-II; 1. PE 3: Inferred from homology; KW Complete proteome; Cytoplasm; NADP; Oxidoreductase; KW Queuosine biosynthesis. FT CHAIN 1 122 NADPH-dependent 7-cyano-7-deazaguanine FT reductase. FT /FTId=PRO_1000148662. SQ SEQUENCE 122 AA; 13700 MW; 01C81A29DCFD9678 CRC64; MPTQPSRDLQ TFPNPKPGRP FEIAMECPEF TCVCPMTGQP DFATIRLRYV PAERCVELKS LKLYLWSFRN EGTFHEAVTN RICDDLVAAL APRWIEVVGD FAVRGGIHTV VTARHGERPA GV //