ID B7ZLD0_HUMAN Unreviewed; 1568 AA. AC B7ZLD0; DT 03-MAR-2009, integrated into UniProtKB/TrEMBL. DT 03-MAR-2009, sequence version 1. DT 18-JAN-2017, entry version 43. DE SubName: Full=LRP6 protein {ECO:0000313|EMBL:AAI43726.1}; GN Name=LRP6 {ECO:0000313|EMBL:AAI43726.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AAI43726.1}; RN [1] {ECO:0000313|EMBL:AAI43726.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Cerebellum {ECO:0000313|EMBL:AAI43726.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., RA Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- SIMILARITY: Contains 19 LDL-receptor class B repeat. CC {ECO:0000256|PROSITE-ProRule:PRU00461}. CC -!- SIMILARITY: Contains 2 LDL-receptor class A domain. CC {ECO:0000256|PROSITE-ProRule:PRU00124}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC143725; AAI43726.1; -; mRNA. DR UniGene; Hs.584775; -. DR UniGene; Hs.658913; -. DR STRING; 9606.ENSP00000261349; -. DR PaxDb; B7ZLD0; -. DR PeptideAtlas; B7ZLD0; -. DR eggNOG; ENOG410IPT4; Eukaryota. DR eggNOG; ENOG410XSY5; LUCA. DR HOVERGEN; HBG049167; -. DR ChiTaRS; LRP6; human. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.120.10.30; -; 4. DR Gene3D; 4.10.400.10; -; 2. DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR023415; LDLR_class-A_CS. DR InterPro; IPR000033; LDLR_classB_rpt. DR InterPro; IPR002172; LDrepeatLR_classA_rpt. DR Pfam; PF00057; Ldl_recept_a; 2. DR Pfam; PF00058; Ldl_recept_b; 11. DR PRINTS; PR00261; LDLRECEPTOR. DR SMART; SM00181; EGF; 4. DR SMART; SM00192; LDLa; 2. DR SMART; SM00135; LY; 20. DR SUPFAM; SSF57424; SSF57424; 2. DR PROSITE; PS01209; LDLRA_1; 2. DR PROSITE; PS50068; LDLRA_2; 2. DR PROSITE; PS51120; LDLRB; 19. PE 2: Evidence at transcript level; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00124, KW ECO:0000256|SAAS:SAAS00497469}; KW EGF-like domain {ECO:0000256|SAAS:SAAS00063520}; KW Membrane {ECO:0000256|SAAS:SAAS00492762, ECO:0000256|SAM:Phobius}; KW Repeat {ECO:0000256|SAAS:SAAS00063653}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00492834, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00492819, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 1568 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002864127. FT TRANSMEM 1329 1349 Helical. {ECO:0000256|SAM:Phobius}. FT REPEAT 63 106 LDL-receptor class B. FT {ECO:0000256|PROSITE-ProRule:PRU00461}. FT REPEAT 107 149 LDL-receptor class B. FT {ECO:0000256|PROSITE-ProRule:PRU00461}. FT REPEAT 150 193 LDL-receptor class B. FT {ECO:0000256|PROSITE-ProRule:PRU00461}. FT REPEAT 194 236 LDL-receptor class B. FT {ECO:0000256|PROSITE-ProRule:PRU00461}. FT DOMAIN 285 324 EGF-like. {ECO:0000259|SMART:SM00181}. FT REPEAT 372 414 LDL-receptor class B. FT {ECO:0000256|PROSITE-ProRule:PRU00461}. FT REPEAT 415 457 LDL-receptor class B. FT {ECO:0000256|PROSITE-ProRule:PRU00461}. FT REPEAT 458 501 LDL-receptor class B. FT {ECO:0000256|PROSITE-ProRule:PRU00461}. FT REPEAT 502 544 LDL-receptor class B. FT {ECO:0000256|PROSITE-ProRule:PRU00461}. FT REPEAT 545 584 LDL-receptor class B. FT {ECO:0000256|PROSITE-ProRule:PRU00461}. FT DOMAIN 591 628 EGF-like. {ECO:0000259|SMART:SM00181}. FT REPEAT 674 716 LDL-receptor class B. FT {ECO:0000256|PROSITE-ProRule:PRU00461}. FT REPEAT 717 759 LDL-receptor class B. FT {ECO:0000256|PROSITE-ProRule:PRU00461}. FT REPEAT 760 802 LDL-receptor class B. FT {ECO:0000256|PROSITE-ProRule:PRU00461}. FT REPEAT 803 839 LDL-receptor class B. FT {ECO:0000256|PROSITE-ProRule:PRU00461}. FT REPEAT 843 885 LDL-receptor class B. FT {ECO:0000256|PROSITE-ProRule:PRU00461}. FT DOMAIN 892 930 EGF-like. {ECO:0000259|SMART:SM00181}. FT REPEAT 977 1025 LDL-receptor class B. FT {ECO:0000256|PROSITE-ProRule:PRU00461}. FT REPEAT 1026 1068 LDL-receptor class B. FT {ECO:0000256|PROSITE-ProRule:PRU00461}. FT REPEAT 1069 1113 LDL-receptor class B. FT {ECO:0000256|PROSITE-ProRule:PRU00461}. FT REPEAT 1114 1156 LDL-receptor class B. FT {ECO:0000256|PROSITE-ProRule:PRU00461}. FT REPEAT 1157 1198 LDL-receptor class B. FT {ECO:0000256|PROSITE-ProRule:PRU00461}. FT DOMAIN 1206 1244 EGF-like. {ECO:0000259|SMART:SM00181}. FT DISULFID 1243 1255 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 1250 1268 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 1262 1277 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 1281 1293 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 1288 1306 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 1300 1315 {ECO:0000256|PROSITE-ProRule:PRU00124}. SQ SEQUENCE 1568 AA; 175450 MW; 2E159CC0D275E590 CRC64; MGAVLRSLLA CSFCVLLRAA PLLLYANRRD LRLVDATNGK ENATIVVGGL EDAAAVDFVF SHGLIYWSDV SEEAIKRTEF NKTESVQNVV VSGLLSPDGL ACDWLGEKLY WTDSETNRIE VSNLDGSLRK VLFWQELDQP RAIALDPSSG FMYWTDWGEV PKIERAGMDG SSRFIIINSE IYWPNGLTLD YEEQKLYWAD AKLNFIHKSN LDGTNRQAVV KGSLPHPFAL TLFEDILYWT DWSTHSILAC NKYTGEGLRE IHSDIFSPMD IHAFSQQRQP NATNPCGIDN GGCSHLCLMS PVKPFYQCAC PTGVKLLENG KTCKDGATEL LLLARRTDLR RISLDTPDFT DIVLQLEDIR HAIAIDYDPV EGYIYWTDDE VRAIRRSFID GSGSQFVVTA QIAHPDGIAV DWVARNLYWT DTGTDRIEVT RLNGTMRKIL ISEDLEEPRA IVLDPMVGYM YWTDWGEIPK IERAALDGSD RVVLVNTSLG WPNGLALDYD EGKIYWGDAK TDKIEVMNTD GTGRRVLVED KIPHIFGFTL LGDYVYWTDW QRRSIERVHK RSAEREVIID QLPDLMGLKA TNVHRVIGSN PCAEENGGCS HLCLYRPQGL RCACPIGFEL ISDMKTCIVP EAFLLFSRRA DIRRISLETN NNNVAIPLTG VKEASALDFD VTDNRIYWTD ISLKTISRAF MNGSALEHVV EFGLDYPEGM AVDWLGKNLY WADTGTNRIE VSKLDGQHRQ VLVWKDLDSP RALALDPAEG FMYWTEWGGK PKIDRAAMDG SERTTLVPNV GRANGLTIDY AKRRLYWTDL DTNLIESSNM LGLNREVIAD DLPHPFGLTQ YQDYIYWTDW SRRSIERANK TSGQNRTIIQ GHLDYVMDIL VFHSSRQSGW NECASSNGHC SHLCLAVPVG GFVCGCPAHY SLNADNRTCS APTTFLLFSQ KSAINRMVID EQQSPDIILP IHSLRNVRAI DYDPLDKQLY WIDSRQNMIR KAQEDGSQGF TVVVSSVPSQ NLEIQPYDLS IDIYSRYIYW TCEATNVINV TRLDGRSVGV VLKGEQDRPR AIVVNPEKGY MYFTNLQERS PKIERAALDG TEREVLFFSG LSKPIALALD SRLGKLFWAD SDLRRIESSD LSGANRIVLE DSNILQPVGL TVFENWLYWI DKQQQMIEKI DMTGREGRTK VQARIAQLSD IHAVKELNLQ EYRQHPCAQD NGGCSHICLV KGDGTTRCSC PMHLVLLQDE LSCGESQFQC ASGQCIDGAL RCNGDANCQD KSDEKNCEVL CLIDQFRCAN GQCIGKHKKC DHNVDCSDKS DELDCYPTEE PAPQATNTVG SVIGVIVTIF VSGTVYFICQ RMLCPRMKGD GETMTNDYVV HGPASVPLGY VPHPSSLSGS LPGMSRGKSM ISSLSIMGGS SGPPYDRAHV TGASSSSSSS TKGTYFPAIL NPPPSPATER SHYTMEFGYS SNSPSTHRSY SYRPYSYRHF APPTTPCSTD VCDSDYAPSR RMTSVATAKG YTSDLNYDSE PVPPPPTPRS QYLSAEENYE SCPPSPYTER SYSHHLYPPP PSPCTDSS //