ID B7ZC46_MOUSE Unreviewed; 440 AA. AC B7ZC46; DT 03-MAR-2009, integrated into UniProtKB/TrEMBL. DT 03-MAR-2009, sequence version 1. DT 27-NOV-2024, entry version 106. DE RecName: Full=Septin {ECO:0000256|PIRNR:PIRNR006698}; GN Name=Septin8 {ECO:0000313|Ensembl:ENSMUSP00000113775.3, GN ECO:0000313|MGI:MGI:894310}; GN Synonyms=Sept8 {ECO:0000313|MGI:MGI:894310}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000113775.3, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0007829|PubMed:16452087} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=16452087; DOI=10.1074/mcp.T500041-MCP200; RA Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.; RT "Comprehensive identification of phosphorylation sites in postsynaptic RT density preparations."; RL Mol. Cell. Proteomics 5:914-922(2006). RN [2] {ECO:0007829|PubMed:17242355} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=17242355; DOI=10.1073/pnas.0609836104; RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; RT "Large-scale phosphorylation analysis of mouse liver."; RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000113775.3, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000113775.3, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RG Mouse Genome Sequencing Consortium; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [4] {ECO:0007829|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and expression."; RL Cell 143:1174-1189(2010). RN [5] {ECO:0000313|Ensembl:ENSMUSP00000113775.3} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000113775.3}; RX PubMed=21750661; RA Church D.M., Schneider V.A., Graves T., Auger K., Cunningham F., Bouk N., RA Chen H.C., Agarwala R., McLaren W.M., Ritchie G.R., Albracht D., RA Kremitzki M., Rock S., Kotkiewicz H., Kremitzki C., Wollam A., Trani L., RA Fulton L., Fulton R., Matthews L., Whitehead S., Chow W., Torrance J., RA Dunn M., Harden G., Threadgold G., Wood J., Collins J., Heath P., RA Griffiths G., Pelan S., Grafham D., Eichler E.E., Weinstock G., RA Mardis E.R., Wilson R.K., Howe K., Flicek P., Hubbard T.; RT "Modernizing reference genome assemblies."; RL PLoS Biol. 9:e1001091-e1001091(2011). RN [6] {ECO:0000313|Ensembl:ENSMUSP00000113775.3} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000113775.3}; RG Ensembl; RL Submitted (AUG-2024) to UniProtKB. CC -!- FUNCTION: Filament-forming cytoskeletal GTPase. May play a role in CC platelet secretion. Seems to participate in the process of SNARE CC complex formation in synaptic vesicles. CC {ECO:0000256|ARBA:ARBA00045813}. CC -!- SUBUNIT: Septins polymerize into heterooligomeric protein complexes CC that form filaments. {ECO:0000256|PIRNR:PIRNR006698}. CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic CC vesicle membrane {ECO:0000256|ARBA:ARBA00004432}. CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like CC GTPase superfamily. Septin GTPase family. CC {ECO:0000256|PIRNR:PIRNR006698, ECO:0000256|RuleBase:RU004560}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_011247136.1; XM_011248834.2. DR AlphaFoldDB; B7ZC46; -. DR SMR; B7ZC46; -. DR PeptideAtlas; B7ZC46; -. DR Antibodypedia; 26134; 227 antibodies from 30 providers. DR DNASU; 20362; -. DR Ensembl; ENSMUST00000120878.9; ENSMUSP00000113775.3; ENSMUSG00000018398.19. DR GeneID; 20362; -. DR UCSC; uc007iwi.2; mouse. DR AGR; MGI:894310; -. DR CTD; 23176; -. DR MGI; MGI:894310; Septin8. DR VEuPathDB; HostDB:ENSMUSG00000018398; -. DR GeneTree; ENSGT00940000156068; -. DR OrthoDB; 5396944at2759; -. DR BioGRID-ORCS; 20362; 5 hits in 50 CRISPR screens. DR ChiTaRS; Sept8; mouse. DR Proteomes; UP000000589; Chromosome 11. DR Bgee; ENSMUSG00000018398; Expressed in humerus cartilage element and 254 other cell types or tissues. DR ExpressionAtlas; B7ZC46; baseline and differential. DR GO; GO:0031105; C:septin complex; IEA:UniProtKB-UniRule. DR GO; GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule. DR CDD; cd01850; CDC_Septin; 1. DR FunFam; 3.40.50.300:FF:000036; septin-6 isoform X2; 1. DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1. DR InterPro; IPR030379; G_SEPTIN_dom. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR016491; Septin. DR PANTHER; PTHR18884; SEPTIN; 1. DR PANTHER; PTHR18884:SF54; SEPTIN-8; 1. DR Pfam; PF00735; Septin; 1. DR PIRSF; PIRSF006698; Septin; 1. DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1. DR PROSITE; PS51719; G_SEPTIN; 1. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils}; KW Cytoplasm {ECO:0000256|PIRNR:PIRNR006698}; KW Cytoskeleton {ECO:0000256|PIRNR:PIRNR006698}; KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU004560}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, KW ECO:0000256|RuleBase:RU004560}; KW Proteomics identification {ECO:0007829|PeptideAtlas:B7ZC46, KW ECO:0007829|ProteomicsDB:B7ZC46}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}. FT DOMAIN 41..305 FT /note="Septin-type G" FT /evidence="ECO:0000259|PROSITE:PS51719" FT REGION 1..23 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 409..440 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 321..399 FT /evidence="ECO:0000256|SAM:Coils" SQ SEQUENCE 440 AA; 50896 MW; 082D175F4731D2CB CRC64; MAATDLERVS NAEPEPRSLS LGGHVGFDSL PDQLVSKSVT QGFSFNILCV GETGIGKSTL MNTLFNTTFE TEEASHHEEC VRLRPQTYDL QESNVHLKLT IVDAVGFGDQ INKDDRPIVD YIDAQFENYL QEELKIRRSL FDYHDTRIHV CLYFITPTGH SLKSLDLVTM KKLDSKVNII PIIAKADTIS KSELHKFKIK IMGELVSNGV QIYQFPTDDE AVAEINAVMN AHLPFAVVGS TEEVKVGNKL VRARQYPWGV VQVENENHCD FVKLREMLIR VNMEDLREQT HSRHYELYRR CKLEEMGFQD SDGDSQPFSL QETYEAKRKE FLSELQRKEE EMRQMFVNKV KETELELKEK ERELHEKFEH LKRIHQEEKR KVEEKRRELE EETNAFNCRK AAMEALQSQA LHATSQQPLR KDKDKKKAGG WSSIYSVTIP //