ID B7Z6Y2_HUMAN Unreviewed; 385 AA. AC B7Z6Y2; DT 03-MAR-2009, integrated into UniProtKB/TrEMBL. DT 03-MAR-2009, sequence version 1. DT 25-MAY-2022, entry version 68. DE SubName: Full=cDNA FLJ54942, highly similar to Homo sapiens bridging integrator 1 (BIN1), transcript variant 10, mRNA {ECO:0000313|EMBL:BAH13418.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAH13418.1}; RN [1] {ECO:0000313|EMBL:BAH13418.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Spleen {ECO:0000313|EMBL:BAH13418.1}; RA Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., RA Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., RA Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T., RA Sugano S., Nomura N., Isogai T.; RT "NEDO human cDNA sequencing project focused on splicing variants."; RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK301153; BAH13418.1; -; mRNA. DR RefSeq; NP_001307563.1; NM_001320634.1. DR PeptideAtlas; B7Z6Y2; -. DR DNASU; 274; -. DR GeneID; 274; -. DR CTD; 274; -. DR OrthoDB; 1366218at2759; -. DR BioGRID-ORCS; 274; 13 hits in 1083 CRISPR screens. DR GenomeRNAi; 274; -. DR GO; GO:0005737; C:cytoplasm; IEA:InterPro. DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt. DR GO; GO:0030100; P:regulation of endocytosis; IEA:InterPro. DR CDD; cd12139; SH3_Bin1; 1. DR Gene3D; 1.20.1270.60; -; 1. DR InterPro; IPR027267; AH/BAR_dom_sf. DR InterPro; IPR003005; Amphiphysin. DR InterPro; IPR035471; Amphiphysin-2_SH3. DR InterPro; IPR003023; Amphiphysin_2. DR InterPro; IPR004148; BAR_dom. DR InterPro; IPR036028; SH3-like_dom_sf. DR InterPro; IPR001452; SH3_domain. DR PANTHER; PTHR46514:SF4; PTHR46514:SF4; 3. DR Pfam; PF03114; BAR; 1. DR Pfam; PF14604; SH3_9; 1. DR PRINTS; PR01251; AMPHIPHYSIN. DR PRINTS; PR01253; AMPHIPHYSIN2. DR PRINTS; PR00452; SH3DOMAIN. DR SMART; SM00721; BAR; 1. DR SMART; SM00326; SH3; 1. DR SUPFAM; SSF103657; SSF103657; 1. DR SUPFAM; SSF50044; SSF50044; 1. DR PROSITE; PS51021; BAR; 1. DR PROSITE; PS50002; SH3; 1. PE 2: Evidence at transcript level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE- KW ProRule:PRU00192}. FT DOMAIN 5..221 FT /note="BAR" FT /evidence="ECO:0000259|PROSITE:PS51021" FT DOMAIN 312..385 FT /note="SH3" FT /evidence="ECO:0000259|PROSITE:PS50002" FT REGION 225..282 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 133..167 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 198..218 FT /evidence="ECO:0000256|SAM:Coils" SQ SEQUENCE 385 AA; 43165 MW; 291A5612A0829A4A CRC64; MMRKVLQKLG KADETKDEQF EQCVQNFNKQ LTEGTRLQKD LRTYLASVKA MHEASKKLNE CLQEVYEPDW PGRDEANKIA ENNDLLWMDY HQKLVDQALL TMDTYLGQFP DIKSRIAKRG RKLVDYDSAR HHYESLQTAK KKDEAKIAKA EEELIKAQKV FEEMNVDLQE ELPSLWNSRV GFYVNTFQSI AGLEENFHKE MSKLNQNLND VLVGLEKQHG SNTFTVKAQP SDNAPAKGNK SPSPPDGSPA ATPEIRVNHE PEPAGGATPG ATLPKSPSQS SLPAVVVETF PATVNGTVEG GSGAGRLDLP PGFMFKVQAQ HDYTATDTDE LQLKAGDVVL VIPFQNPEEQ DEGWLMGVKE SDWNQHKELE KCRGVFPENF TERVP //