ID   B7Z2R1_HUMAN            Unreviewed;       961 AA.
AC   B7Z2R1;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   28-MAR-2018, entry version 53.
DE   SubName: Full=cDNA FLJ55344, highly similar to Dysferlin {ECO:0000313|EMBL:BAH11947.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAH11947.1};
RN   [1] {ECO:0000313|EMBL:BAH11947.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain {ECO:0000313|EMBL:BAH11947.1};
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K.,
RA   Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y.,
RA   Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M.,
RA   Kisu Y., Nishikawa T., Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project focused on splicing variants.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AK295004; BAH11947.1; -; mRNA.
DR   UniGene; Hs.252180; -.
DR   PeptideAtlas; B7Z2R1; -.
DR   PRIDE; B7Z2R1; -.
DR   eggNOG; KOG1326; Eukaryota.
DR   eggNOG; ENOG410XPT2; LUCA.
DR   HOGENOM; HOG000006771; -.
DR   HOVERGEN; HBG106341; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   CDD; cd04017; C2D_Ferlin; 1.
DR   CDD; cd04037; C2E_Ferlin; 1.
DR   CDD; cd08374; C2F_Ferlin; 1.
DR   Gene3D; 2.60.40.150; -; 4.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR037723; C2D_Ferlin.
DR   InterPro; IPR037724; C2E_Ferlin.
DR   InterPro; IPR037725; C2F_Ferlin.
DR   InterPro; IPR029998; Dysferlin.
DR   InterPro; IPR037721; Ferlin.
DR   InterPro; IPR032362; Ferlin_C.
DR   PANTHER; PTHR12546; PTHR12546; 1.
DR   PANTHER; PTHR12546:SF44; PTHR12546:SF44; 1.
DR   Pfam; PF00168; C2; 4.
DR   Pfam; PF16165; Ferlin_C; 1.
DR   SMART; SM00239; C2; 4.
DR   PROSITE; PS50004; C2; 2.
PE   2: Evidence at transcript level;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    926    948       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       20    125       C2. {ECO:0000259|PROSITE:PS50004}.
FT   DOMAIN      446    544       C2. {ECO:0000259|PROSITE:PS50004}.
SQ   SEQUENCE   961 AA;  110847 MW;  E04948F52DD9DCB5 CRC64;
     MDDKSEDSMS VSTLSFGVNR PTISCIFDYG NRYHLRCYMY QARDLAAMDK DSFSDPYAIV
     SFLHQSQKTV VVKNTLNPTW DQTLIFYEIE IFGEPATVAE QPPSIVVELY DHDTYGADEF
     MGRCICQPSL ERMPRLAWFP LTRGSQPSGE LLASFELIQR EKPAIHHIPG FEVQETSRIL
     DESEDTDLPY PPPQREANIY MVPQNIKPAL QRTAIEILAW GLRNMKSYQL ANISSPSLVV
     ECGGQTVQSC VIRNLRKNPN FDICTLFMEV MLPREELYCP PITVKVIDNR QFGRRPVVGQ
     CTIRSLESFL CDPYSAESPS PQGGPDDVSL LSPGEDVLID IDDKEPLIPI QEEEFIDWWS
     KFFASIGERE KCGSYLEKDF DTLKVYDTQL ENVEAFEGLS DFCNTFKLYR GKTQEETEDP
     SVIGEFKGLF KIYPLPEDPA IPMPPRQFHQ LAAQGPQECL VRIYIVRAFG LQPKDPNGKC
     DPYIKISIGK KSVSDQDNYI PCTLEPVFGK MFELTCTLPL EKDLKITLYD YDLLSKDEKI
     GETVVDLENR LLSKFGARCG LPQTYCVSGP NQWRDQLRPS QLLHLFCQQH RVKAPVYRTD
     RVMFQDKEYS IEEIEAGRIP NPHLGPVEER LALHVLQQQG LVPEHVESRP LYSPLQPDIE
     QGKLQMWVDL FPKALGRPGP PFNITPRRAR RFFLRCIIWN TRDVILDDLS LTGEKMSDIY
     VKGWMIGFEE HKQKTDVHYR SLGGEGNFNW RFIFPFDYLP AEQVCTIAKK DAFWRLDKTE
     SKIPARVVFQ IWDNDKFSFD DFLGSLQLDL NRMPKPAKTA KKCSLDQLDD AFHPEWFVSL
     FEQKTVKGWW PCVAEEGEKK ILAGKLEMTL EIVAESEHEE RPAGQGRDEP NMNPKLEDPR
     RPDTSFLWFT SPYKTMKFIL WRRFRWAIIL FIILFILLLF LAIFIYAFPN YAAMKLVKPF
     S
//