ID B7Z012_DROME Unreviewed; 1107 AA. AC B7Z012; DT 03-MAR-2009, integrated into UniProtKB/TrEMBL. DT 03-MAR-2009, sequence version 1. DT 24-JAN-2024, entry version 111. DE SubName: Full=Cappuccino, isoform H {ECO:0000313|EMBL:ACL82993.1}; GN Name=capu {ECO:0000313|EMBL:ACL82993.1, GN ECO:0000313|FlyBase:FBgn0000256}; GN Synonyms=capp {ECO:0000313|EMBL:ACL82993.1}, Capu GN {ECO:0000313|EMBL:ACL82993.1}, CG15420 {ECO:0000313|EMBL:ACL82993.1}, GN Dmel\CG3399 {ECO:0000313|EMBL:ACL82993.1}; GN ORFNames=CG3399 {ECO:0000313|EMBL:ACL82993.1, GN ECO:0000313|FlyBase:FBgn0000256}, Dmel_CG3399 GN {ECO:0000313|EMBL:ACL82993.1}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:ACL82993.1, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:ACL82993.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster RT euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic RT review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., RA Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: a RT genomics perspective."; RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002). RN [5] {ECO:0000313|EMBL:ACL82993.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:ACL82993.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [7] {ECO:0000313|EMBL:ACL82993.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."; RL Science 316:1586-1591(2007). RN [8] {ECO:0000313|EMBL:ACL82993.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). CC -!- SIMILARITY: Belongs to the formin homology family. Cappuccino CC subfamily. {ECO:0000256|ARBA:ARBA00005271}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014134; ACL82993.1; -; Genomic_DNA. DR RefSeq; NP_001137786.1; NM_001144314.2. DR AlphaFoldDB; B7Z012; -. DR SMR; B7Z012; -. DR DNASU; 33611; -. DR EnsemblMetazoa; FBtr0290080; FBpp0288519; FBgn0000256. DR GeneID; 33611; -. DR AGR; FB:FBgn0000256; -. DR CTD; 33611; -. DR FlyBase; FBgn0000256; capu. DR VEuPathDB; VectorBase:FBgn0000256; -. DR GeneTree; ENSGT00940000165811; -. DR OMA; HCDTSVV; -. DR OrthoDB; 53873at2759; -. DR BioGRID-ORCS; 33611; 0 hits in 3 CRISPR screens. DR ChiTaRS; capu; fly. DR GenomeRNAi; 33611; -. DR Proteomes; UP000000803; Chromosome 2L. DR Bgee; FBgn0000256; Expressed in testis and 32 other cell types or tissues. DR ExpressionAtlas; B7Z012; baseline and differential. DR Genevisible; B7Z012; DM. DR GO; GO:0005884; C:actin filament; IEA:InterPro. DR GO; GO:0008017; F:microtubule binding; IEA:InterPro. DR GO; GO:0045010; P:actin nucleation; IEA:InterPro. DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1. DR InterPro; IPR015425; FH2_Formin. DR InterPro; IPR042201; FH2_Formin_sf. DR InterPro; IPR001265; Formin_Cappuccino_subfam. DR PANTHER; PTHR45920; FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I; 1. DR PANTHER; PTHR45920:SF4; FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I; 1. DR Pfam; PF02181; FH2; 1. DR PRINTS; PR00828; FORMIN. DR SMART; SM00498; FH2; 1. DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1. DR PROSITE; PS51444; FH2; 1. PE 3: Inferred from homology; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}. FT DOMAIN 633..1080 FT /note="FH2" FT /evidence="ECO:0000259|PROSITE:PS51444" FT REGION 50..102 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 156..197 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 496..695 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 50..67 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 156..174 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 179..193 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 502..516 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 530..607 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 664..680 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1107 AA; 120742 MW; 3333BFE7FF54BDD0 CRC64; MQTDIVFCKA PAKPPRLRRQ LQTPVESEDH CSLSLGQLCQ LQLQYDNKRH EEESQRILMR EKERVQNTPP LTKQPRKRRI APQPPPKPPP KPRKIRTEKT TNDDHCAFIE QLFFETTEAK PSATVVAGVT GPAGPLGATT SSPSLETQST VIISFKSSQT PVQSQTNSAA SENVEDDTAP LPLPPPPPGF GTPTTPLLSS NVLKKVASFT VEKSSAGNNS SNPPNLCPTS DETTLLATPC SSSLTVATLP PEIAVGAAAG GVAGGAGSRR GSSYVPEKLS FAAYEKFEGQ MLIKWLISTM QSNPKSSSGD ANQELFNTLA LQFCNNLKYV GVLKQISNEH LDCGFSPYEM YQWTHTEQPT TSLPLTPGKL DKVAAWPFSS TPSGIRALES ASLASLGAGG VAGSLATIAT ASTASSDNQK TLQQILKKRL LNCTTLAEVH AVVNELLSSV DEPPRRPSKR CVNLTELLNA SEATVYEYNK TGAEGCVKSF TDAETQTESE DCEGTCKCGQ SSTKVSDNES AKEDGEKPHA VAPPPPPPPP PLHAFVAPPP PPPPPPPPPP PLANYGAPPP PPPPPPGSGS APPPPPPAPI EGGGGIPPPP PPMSASPSKT TISPAPLPDP AEGNWFHRTN TMRKSAVNPP KPMRPLYWTR IVTSAPPAPR PPSVANSTDS TENSGSSPDE PPAANGADAP PTAPPATKEI WTEIEETPLD NIDEFTELFS RQAIAPVSKP KELKVKRAKS IKVLDPERSR NVGIIWRSLH VPSSEIEHAI YHIDTSVVSL EALQHMSNIQ ATEDELQRIK EAAGGDIPLD HPEQFLLDIS LISMASERIS CIVFQAEFEE SVTLLFRKLE TVSQLSQQLI ESEDLKLVFS IILTLGNYMN GGNRQRGQAD GFNLDILGKL KDVKSKESHT TLLHFIVRTY IAQRRKEGVH PLEIRLPIPE PADVERAAQM DFEEVQQQIF DLNKKFLGCK RTTAKVLAAS RPEIMEPFKS KMEEFVEGAD KSMAKLHQSL DECRDLFLET MRFYHFSPKA CTLTLAQCTP DQFFEYWTNF TNDFKDIWKK EITSLLNELM KKSKQAQIES RRNVSTKVEK SGRISLKERM LMRRSKN //