ID B7UEA1_9BIVA Unreviewed; 511 AA. AC B7UEA1; DT 10-FEB-2009, integrated into UniProtKB/TrEMBL. DT 10-FEB-2009, sequence version 1. DT 03-SEP-2014, entry version 27. DE RecName: Full=Cytochrome c oxidase subunit 1; DE EC=1.9.3.1; GN Name=COX1; OS Hyriopsis cumingii. OG Mitochondrion. OC Eukaryota; Metazoa; Lophotrochozoa; Mollusca; Bivalvia; OC Palaeoheterodonta; Unionoida; Unionoidea; Unionidae; Unioninae; OC Hyriopsis. OX NCBI_TaxID=165450; RN [1] RP NUCLEOTIDE SEQUENCE. RA Zheng R.L., Li J.L.; RL Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory CC chain that catalyzes the reduction of oxygen to water. Subunits 1- CC 3 form the functional core of the enzyme complex. CO I is the CC catalytic subunit of the enzyme. Electrons originating in CC cytochrome c are transferred via the copper A center of subunit 2 CC and heme A of subunit 1 to the bimetallic center formed by heme A3 CC and copper B (By similarity). CC -!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) + 4 H(+) = 4 CC ferricytochrome c + 2 H(2)O. CC -!- PATHWAY: Energy metabolism; oxidative phosphorylation. CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass CC membrane protein (By similarity). CC -!- SIMILARITY: Belongs to the heme-copper respiratory oxidase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; FJ529186; ACK57380.1; -; Genomic_DNA. DR RefSeq; YP_002427675.1; NC_011763.1. DR GeneID; 7138842; -. DR CTD; 4512; -. DR UniPathway; UPA00705; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW. DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC. DR GO; GO:0020037; F:heme binding; IEA:InterPro. DR GO; GO:0005506; F:iron ion binding; IEA:InterPro. DR GO; GO:0009060; P:aerobic respiration; IEA:InterPro. DR GO; GO:0006119; P:oxidative phosphorylation; IEA:UniProtKB-UniPathway. DR Gene3D; 1.20.210.10; -; 1. DR InterPro; IPR000883; COX1. DR InterPro; IPR023615; Cyt_c_Oxase_su1_BS. DR InterPro; IPR023616; Cyt_c_Oxase_su1_dom. DR PANTHER; PTHR10422; PTHR10422; 1. DR Pfam; PF00115; COX1; 1. DR PRINTS; PR01165; CYCOXIDASEI. DR SUPFAM; SSF81442; SSF81442; 1. DR PROSITE; PS50855; COX1; 1. DR PROSITE; PS00077; COX1_CUB; 1. PE 3: Inferred from homology; KW Copper; Electron transport; Heme; Iron; Membrane; Metal-binding; KW Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; KW Respiratory chain; Transmembrane; Transport. SQ SEQUENCE 511 AA; 56146 MW; 1432D926B65320A8 CRC64; MRWLCSTNHK DIGTLYLLLA LWSGLIGLAL SLLIRAELGQ PGSLLGDDQL YNVIVTAHAF MMIFFLVMPM MIGGFGNWLI PLMIGAPDMA FPRLNNLSFW LLVPALFLLL SSSLVESGVG TGWTVYPPLS GNVAHSGASV DLAIFSLHLA GASSILGAIN FISTVGNMRS PGLVAERIPL FVWAVTVTAI LLVAALPVLA GAITMLLTDR NLNTSFFDPT GGGDPILYMH LFWFFGHPEV YILILPGFGM ISHIVMHYAG KKQVFGYLGM VYAIVSIGVL GFIVWAHHMF TVGMDVDTRA YFTAATMIIA VPTGIKVFSW LATIHGFVNK TEPPILWALG FIFLFTVGGL TGIVLSNSSL DIVLHDTYYV VAHFHYVLSM GAVFALFSAF SYWYPLISGV TFHAVWSKVH FVLMFVGVNL TFFPQHFLGL AGMPRRYSDY PDSFAKWNVV SSWGSLISFV SVLLFMFMLL ESFVSQRSVV WGSALSSSFE WQDANFPASF HSNSQMAKVF V //