ID B7TIY3_9COLE Unreviewed; 219 AA. AC B7TIY3; B8Y1F8; DT 10-FEB-2009, integrated into UniProtKB/TrEMBL. DT 24-MAR-2009, sequence version 2. DT 08-JUN-2016, entry version 37. DE RecName: Full=Cytochrome c oxidase subunit 1 {ECO:0000256|RuleBase:RU000369}; DE EC=1.9.3.1 {ECO:0000256|RuleBase:RU000369}; DE Flags: Fragment; GN Name=COI {ECO:0000313|EMBL:ACL79630.2}; OS Hatchiana sp. THK-2008. OG Mitochondrion {ECO:0000313|EMBL:ACJ54125.2}. OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Endopterygota; Coleoptera; Polyphaga; OC Elateriformia; Elateroidea; Cantharidae; Cantharinae; Hatchiana. OX NCBI_TaxID=568066 {ECO:0000313|EMBL:ACJ54125.2}; RN [1] {ECO:0000313|EMBL:ACN41867.1} RP NUCLEOTIDE SEQUENCE. RA Kang T.H., Kim J.I., Kim M.A., Park H.C.; RT "Taxonomic review of the genus Hatchiana Fender, 1966 (Coleoptera: RT Cantharidae) in Korea based on morphological data and DNA barcodes."; RL Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:ACJ54125.2} RP NUCLEOTIDE SEQUENCE. RA Kang T.H., Park H.C., Kim J.I.; RT "A review of the genus Hatchiana Fender, 1966 (Coleoptera: RT Cantharidae) from Korea using morphological and molecular data."; RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:ACL79630.2} RP NUCLEOTIDE SEQUENCE. RA Kang T.H., Park H.C., Kim J.I., Kim M.A.; RT "Taxonomic review of the genus Hatchiana fender, 1966 (Coleoptera: RT Cantharidae) in Korea based on morphological data and DNA barcode."; RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|EMBL:ADC36182.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=HASPAA {ECO:0000313|EMBL:ADC36182.1}, HASPAB RC {ECO:0000313|EMBL:ADC36183.1}, and HASPAC RC {ECO:0000313|EMBL:ADC36184.1}; RA Kang T.H., Park H.C., Han T.M., Kim M.A., Lee Y.B.; RT "Taxonomic Review of the Genus Hatchiana Fender 1966 (Coleoptera: RT Cantharidae) in Korea Based on Morphological Data and DNA Barcodes."; RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory CC chain that catalyzes the reduction of oxygen to water. Subunits 1- CC 3 form the functional core of the enzyme complex. CO I is the CC catalytic subunit of the enzyme. Electrons originating in CC cytochrome c are transferred via the copper A center of subunit 2 CC and heme A of subunit 1 to the bimetallic center formed by heme A3 CC and copper B. {ECO:0000256|RuleBase:RU000369}. CC -!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) + 4 H(+) = 4 CC ferricytochrome c + 2 H(2)O. {ECO:0000256|RuleBase:RU000369}. CC -!- PATHWAY: Energy metabolism; oxidative phosphorylation. CC {ECO:0000256|RuleBase:RU000369}. CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane CC {ECO:0000256|RuleBase:RU000369}; Multi-pass membrane protein CC {ECO:0000256|RuleBase:RU000369}. CC -!- SIMILARITY: Belongs to the heme-copper respiratory oxidase family. CC {ECO:0000256|RuleBase:RU000369}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; FJ232990; ACJ54125.2; -; Genomic_DNA. DR EMBL; FJ462775; ACL79630.2; -; Genomic_DNA. DR EMBL; FJ646621; ACN41867.1; -; Genomic_DNA. DR EMBL; GU323939; ADC36182.1; -; Genomic_DNA. DR EMBL; GU323940; ADC36183.1; -; Genomic_DNA. DR EMBL; GU323941; ADC36184.1; -; Genomic_DNA. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW. DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC. DR GO; GO:0020037; F:heme binding; IEA:InterPro. DR GO; GO:0005506; F:iron ion binding; IEA:InterPro. DR GO; GO:0009060; P:aerobic respiration; IEA:InterPro. DR GO; GO:0006119; P:oxidative phosphorylation; IEA:UniProtKB-UniPathway. DR Gene3D; 1.20.210.10; -; 1. DR InterPro; IPR000883; COX1. DR InterPro; IPR023616; Cyt_c_Oxase_su1_dom. DR PANTHER; PTHR10422; PTHR10422; 1. DR Pfam; PF00115; COX1; 1. DR PRINTS; PR01165; CYCOXIDASEI. DR SUPFAM; SSF81442; SSF81442; 1. DR PROSITE; PS50855; COX1; 1. PE 3: Inferred from homology; KW Copper {ECO:0000256|RuleBase:RU000369}; KW Electron transport {ECO:0000256|RuleBase:RU000369}; KW Heme {ECO:0000256|RuleBase:RU000369}; KW Iron {ECO:0000256|RuleBase:RU000369}; KW Membrane {ECO:0000256|RuleBase:RU000369, ECO:0000256|SAM:Phobius}; KW Metal-binding {ECO:0000256|RuleBase:RU000369}; KW Mitochondrion {ECO:0000256|RuleBase:RU000369, KW ECO:0000313|EMBL:ACJ54125.2}; KW Mitochondrion inner membrane {ECO:0000256|RuleBase:RU000369}; KW Oxidoreductase {ECO:0000256|RuleBase:RU000369}; KW Respiratory chain {ECO:0000256|RuleBase:RU000369}; KW Transmembrane {ECO:0000256|RuleBase:RU000369, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}; KW Transport {ECO:0000256|RuleBase:RU000369}. FT TRANSMEM 46 67 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 88 110 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 130 155 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 167 194 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 219 COX1. {ECO:0000259|PROSITE:PS50855}. FT NON_TER 1 1 {ECO:0000313|EMBL:ACJ54125.2}. FT NON_TER 219 219 {ECO:0000313|EMBL:ACJ54125.2}. SQ SEQUENCE 219 AA; 23718 MW; 10D9D2D3CB4D4482 CRC64; TLYFIFGAWS GSLGLALSLL IRAELGTPGT LIGNDQLYNV IVTAHAFIMI FFMVMPIMIG GFGNWLVPLM LGAPDMAFPR MNNMSFWFLP PSLMFLLMSS MVESGAGTGW TVYPPLSANI AHSGPSVDLA IFSLHMAGIS SILGAVNFIS TIMNMKPPSM KFDQMPLFVW SVGITALLLL LSLPVLAGAI TMLLSDRNLN TSFFDPMGGG DPILYQHLF //