ID B7NWJ5_9INFA Unreviewed; 705 AA. AC B7NWJ5; DT 10-FEB-2009, integrated into UniProtKB/TrEMBL. DT 10-FEB-2009, sequence version 1. DT 31-JUL-2019, entry version 39. DE RecName: Full=RNA-directed RNA polymerase catalytic subunit {ECO:0000256|RuleBase:RU004330, ECO:0000256|SAAS:SAAS00997580}; DE EC=2.7.7.48 {ECO:0000256|RuleBase:RU004330, ECO:0000256|SAAS:SAAS01005265}; DE Flags: Fragment; GN Name=PB1 {ECO:0000313|EMBL:ACJ26173.1}; OS Influenza A virus (A/common kestrel/Hong Kong/2372/2007(H5N1)). OC Viruses; Riboviria; Negarnaviricota; Polyploviricotina; OC Insthoviricetes; Articulavirales; Orthomyxoviridae; OC Alphainfluenzavirus. OX NCBI_TaxID=573957 {ECO:0000313|EMBL:ACJ26173.1}; RN [1] {ECO:0000313|EMBL:ACJ26173.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=A/common kestrel/Hong Kong/2372/2007 RC {ECO:0000313|EMBL:ACJ26173.1}; RX PubMed=19239752; DOI=10.3201/eid1503.081190; RA Smith G.J., Vijaykrishna D., Ellis T.M., Dyrting K.C., Leung Y.H., RA Bahl J., Wong C.W., Kai H., Chow M.K., Duan L., Chan A.S., Zhang L.J., RA Chen H., Luk G.S., Peiris J.S., Guan Y.; RT "Characterization of avian influenza viruses A (H5N1) from wild birds, RT Hong Kong, 2004-2008."; RL Emerg. Infect. Dis. 15:402-407(2009). CC -!- CATALYTIC ACTIVITY: CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:11128, Rhea:RHEA- CC COMP:11129, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, CC ChEBI:CHEBI:83400; EC=2.7.7.48; CC Evidence={ECO:0000256|RuleBase:RU004330, CC ECO:0000256|SAAS:SAAS01176592}; CC -!- SIMILARITY: Belongs to the influenza viruses polymerase PB1 CC family. {ECO:0000256|SAAS:SAAS00997533}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CY036123; ACJ26173.1; -; Viral_cRNA. DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW. DR GO; GO:0003723; F:RNA binding; IEA:InterPro. DR GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-KW. DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro. DR InterPro; IPR007099; RNA-dir_pol_NSvirus. DR InterPro; IPR001407; RNA_pol_PB1_influenza. DR Pfam; PF00602; Flu_PB1; 1. DR PROSITE; PS50525; RDRP_SSRNA_NEG_SEG; 1. PE 3: Inferred from homology; KW Nucleotide-binding {ECO:0000256|SAAS:SAAS01176568}; KW Nucleotidyltransferase {ECO:0000256|SAAS:SAAS01176569}; KW RNA-directed RNA polymerase {ECO:0000256|RuleBase:RU004330, KW ECO:0000256|SAAS:SAAS01176590}; KW Transferase {ECO:0000256|SAAS:SAAS01176594}; KW Viral RNA replication {ECO:0000256|SAAS:SAAS01176589}. FT DOMAIN 274 471 RdRp catalytic. {ECO:0000259|PROSITE: FT PS50525}. FT REGION 38 70 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT COMPBIAS 38 53 Polar. {ECO:0000256|SAM:MobiDB-lite}. FT NON_TER 1 1 {ECO:0000313|EMBL:ACJ26173.1}. FT NON_TER 705 705 {ECO:0000313|EMBL:ACJ26173.1}. SQ SEQUENCE 705 AA; 80367 MW; B38E84904A130BB1 CRC64; PVQNAISTTF PYTGDPPYSH GTGTGYTMDT VNRTHQYSEK GKWTTNTETG APQLNPIDGP LPEDNEPSGY AQTDCVLEAM AFLEESHPGI FENSCLETME IVQQTRVDKL TQGRQTYDWT LNRNQPAATA LANTIEVFRS NGLTANESGR LIDFLKDVIE SMDKEEMEIT THFQRKRRVR DNMTKKMVTQ RTIGKKKQRL NKRSYLIRAL TLNTMTKDAE RGKLKRRAIA TPGMQIRGFV YFVETLARSI CEKLEQSGLP VGGNEKKAKL ANVVRKMMTN SQDTELSFTI TGDNTKWNEN QNPRMFLAMI TYITRNQPEW FRNVLSIAPI MFSNKMARLG KGYMFESKSM KLRTQIPAEM LANIDLKYFN ELTKKKIEKI RPLLIDGTAS LSPGMMMGMF NMLSTVLGVS ILNLGQKRYT KTTYWWDGLQ SSDDFALIVN APNHEGIQAG VDRFYRTCKL VGINMSKKKS YINRTGTFEF TSFFYRYGFV ANFSMELPSF GVSGINESAD MSIGVTVIKN NMINNDLGPA TAQMALQLFI KDYRYTYRCH RGDTQIQTRR SFELKKLWEQ TRSKAGLLVS DGGPNLYNIR NLHIPEVCLK WELMDEDYQG RLCNPLNPFV SHKEIESVNN AIVMPAHGPA KSMEYDAVAT THSWIPKRNR SILNTSQRGI LEDEQMYQKC CNLFEKFFPS SSYRRPVGIS SMVES //