ID B7NWJ5_9INFA Unreviewed; 705 AA. AC B7NWJ5; DT 10-FEB-2009, integrated into UniProtKB/TrEMBL. DT 10-FEB-2009, sequence version 1. DT 16-OCT-2013, entry version 18. DE RecName: Full=RNA-directed RNA polymerase catalytic subunit; DE EC=2.7.7.48; DE Flags: Fragment; GN Name=PB1; OS Influenza A virus (A/common kestrel/Hong Kong/2372/2007(H5N1)). OC Viruses; ssRNA negative-strand viruses; Orthomyxoviridae; OC Influenzavirus A. OX NCBI_TaxID=573957; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=A/common kestrel/Hong Kong/2372/2007; RX PubMed=19239752; DOI=10.3201/eid1503.081190; RA Smith G.J., Vijaykrishna D., Ellis T.M., Dyrting K.C., Leung Y.H., RA Bahl J., Wong C.W., Kai H., Chow M.K., Duan L., Chan A.S., Zhang L.J., RA Chen H., Luk G.S., Peiris J.S., Guan Y.; RT "Characterization of avian influenza viruses A (H5N1) from wild birds, RT Hong Kong, 2004-2008."; RL Emerg. Infect. Dis. 15:402-407(2009). CC -!- CATALYTIC ACTIVITY: Nucleoside triphosphate + RNA(n) = diphosphate CC + RNA(n+1). CC -!- SIMILARITY: Contains RdRp catalytic domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CY036123; ACJ26173.1; -; Viral_cRNA. DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW. DR GO; GO:0003968; F:RNA-directed RNA polymerase activity; IEA:UniProtKB-KW. DR GO; GO:0006351; P:transcription, DNA-dependent; IEA:InterPro. DR GO; GO:0019079; P:viral genome replication; IEA:InterPro. DR InterPro; IPR007099; RNA-dir_pol_NSvirus. DR InterPro; IPR001407; RNA_pol_PB1_influenza. DR Pfam; PF00602; Flu_PB1; 1. DR PROSITE; PS50525; RDRP_SSRNA_NEG_SEG; 1. PE 4: Predicted; KW Nucleotide-binding; Nucleotidyltransferase; KW RNA-directed RNA polymerase; Transferase; Viral RNA replication. FT NON_TER 1 1 FT NON_TER 705 705 SQ SEQUENCE 705 AA; 80367 MW; B38E84904A130BB1 CRC64; PVQNAISTTF PYTGDPPYSH GTGTGYTMDT VNRTHQYSEK GKWTTNTETG APQLNPIDGP LPEDNEPSGY AQTDCVLEAM AFLEESHPGI FENSCLETME IVQQTRVDKL TQGRQTYDWT LNRNQPAATA LANTIEVFRS NGLTANESGR LIDFLKDVIE SMDKEEMEIT THFQRKRRVR DNMTKKMVTQ RTIGKKKQRL NKRSYLIRAL TLNTMTKDAE RGKLKRRAIA TPGMQIRGFV YFVETLARSI CEKLEQSGLP VGGNEKKAKL ANVVRKMMTN SQDTELSFTI TGDNTKWNEN QNPRMFLAMI TYITRNQPEW FRNVLSIAPI MFSNKMARLG KGYMFESKSM KLRTQIPAEM LANIDLKYFN ELTKKKIEKI RPLLIDGTAS LSPGMMMGMF NMLSTVLGVS ILNLGQKRYT KTTYWWDGLQ SSDDFALIVN APNHEGIQAG VDRFYRTCKL VGINMSKKKS YINRTGTFEF TSFFYRYGFV ANFSMELPSF GVSGINESAD MSIGVTVIKN NMINNDLGPA TAQMALQLFI KDYRYTYRCH RGDTQIQTRR SFELKKLWEQ TRSKAGLLVS DGGPNLYNIR NLHIPEVCLK WELMDEDYQG RLCNPLNPFV SHKEIESVNN AIVMPAHGPA KSMEYDAVAT THSWIPKRNR SILNTSQRGI LEDEQMYQKC CNLFEKFFPS SSYRRPVGIS SMVES //