ID   MDTK_ECO81              Reviewed;         457 AA.
AC   B7MV43;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   29-OCT-2014, entry version 46.
DE   RecName: Full=Multidrug resistance protein MdtK {ECO:0000255|HAMAP-Rule:MF_00400};
DE   AltName: Full=Multidrug-efflux transporter {ECO:0000255|HAMAP-Rule:MF_00400};
GN   Name=mdtK {ECO:0000255|HAMAP-Rule:MF_00400};
GN   OrderedLocusNames=ECED1_1862;
OS   Escherichia coli O81 (strain ED1a).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=585397;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ED1a;
RX   PubMed=19165319; DOI=10.1371/journal.pgen.1000344;
RA   Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P.,
RA   Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A.,
RA   Chiapello H., Clermont O., Cruveiller S., Danchin A., Diard M.,
RA   Dossat C., Karoui M.E., Frapy E., Garry L., Ghigo J.M., Gilles A.M.,
RA   Johnson J., Le Bouguenec C., Lescat M., Mangenot S.,
RA   Martinez-Jehanne V., Matic I., Nassif X., Oztas S., Petit M.A.,
RA   Pichon C., Rouy Z., Ruf C.S., Schneider D., Tourret J., Vacherie B.,
RA   Vallenet D., Medigue C., Rocha E.P.C., Denamur E.;
RT   "Organised genome dynamics in the Escherichia coli species results in
RT   highly diverse adaptive paths.";
RL   PLoS Genet. 5:E1000344-E1000344(2009).
CC   -!- FUNCTION: Multidrug efflux pump that functions probably as a
CC       Na(+)/drug antiporter. {ECO:0000255|HAMAP-Rule:MF_00400}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_00400}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_00400}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE)
CC       (TC 2.A.66.1) family. MdtK subfamily. {ECO:0000255|HAMAP-
CC       Rule:MF_00400}.
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DR   EMBL; CU928162; CAR07959.1; -; Genomic_DNA.
DR   RefSeq; YP_002397820.1; NC_011745.1.
DR   ProteinModelPortal; B7MV43; -.
DR   SMR; B7MV43; 1-457.
DR   STRING; 585397.ECED1_1862; -.
DR   BindingDB; B7MV43; -.
DR   EnsemblBacteria; CAR07959; CAR07959; ECED1_1862.
DR   GeneID; 7142745; -.
DR   KEGG; ecq:ECED1_1862; -.
DR   PATRIC; 38487745; VBIEscCol8292_1880.
DR   eggNOG; COG0534; -.
DR   HOGENOM; HOG000038538; -.
DR   KO; K03327; -.
DR   OMA; GGVGCGW; -.
DR   OrthoDB; EOG6423C5; -.
DR   BioCyc; ECOL585397:GJCU-1882-MONOMER; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-HAMAP.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0015238; F:drug transmembrane transporter activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-HAMAP.
DR   HAMAP; MF_00400; MdtK; 1.
DR   InterPro; IPR002528; MATE.
DR   InterPro; IPR022913; Multidrug-R_MdtK.
DR   Pfam; PF01554; MatE; 2.
DR   TIGRFAMs; TIGR00797; matE; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell inner membrane; Cell membrane; Complete proteome;
KW   Ion transport; Membrane; Sodium; Sodium transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN         1    457       Multidrug resistance protein MdtK.
FT                                /FTId=PRO_1000134545.
FT   TRANSMEM     11     31       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00400}.
FT   TRANSMEM     53     73       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00400}.
FT   TRANSMEM     93    113       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00400}.
FT   TRANSMEM    127    147       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00400}.
FT   TRANSMEM    160    180       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00400}.
FT   TRANSMEM    189    209       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00400}.
FT   TRANSMEM    243    263       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00400}.
FT   TRANSMEM    276    296       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00400}.
FT   TRANSMEM    314    334       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00400}.
FT   TRANSMEM    350    370       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00400}.
FT   TRANSMEM    387    407       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00400}.
FT   TRANSMEM    418    438       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00400}.
SQ   SEQUENCE   457 AA;  49447 MW;  33A60FC42ED6CFD7 CRC64;
     MQKYISEARL LLALAIPVIL AQIAQTAMGF VDTVMAGGYS ATDMAAVAIG TSIWLPAILF
     GHGLLLALTP VIAQLNGSGR RERIAHQVRQ GFWLAGFVSV LIMLVLWNAG YIIRSMENID
     PALADKAVGY LRALLWGAPG YLFFQVARNQ CEGLAKTKPG MVMGFIGLLV NIPVNYIFIY
     GHFGMPELGG VGCGVATAAV YWVMFLAMVS YIKRARSMRD IRNEKGTAKP DPAVMKRLIQ
     LGLPIALALF FEVTLFAVVA LLVSPLGIVD VAGHQIALNF SSLMFVLPMS LAAAVTIRVG
     YRLGQGSTLD AQTAARTGLM VGVCMATLTA IFTVSLREQI ALLYNDNPEV VTLAAHLMLL
     AAVYQISDSI QVIGSGILRG YKDTRSIFYI TFTAYWVLGL PSGYILALTD LVVEPMGPAG
     FWIGFIIGLT SAAIMMMLRM RFLQRLPSAI ILQRASR
//