ID B6RFL1_KLEPN Unreviewed; 189 AA. AC B6RFL1; DT 16-DEC-2008, integrated into UniProtKB/TrEMBL. DT 16-DEC-2008, sequence version 1. DT 03-MAY-2023, entry version 98. DE SubName: Full=Conserved domain protein {ECO:0000313|EMBL:ACI63186.1}; DE SubName: Full=MPF resolvase Uvp1 for plasmid R46 {ECO:0000313|EMBL:CDF32047.1}; DE SubName: Full=Recombinase family protein {ECO:0000313|EMBL:QOU54602.1}; DE SubName: Full=Resolvase {ECO:0000313|EMBL:ABY74391.1}; DE SubName: Full=Resolvase Uvp1 {ECO:0000313|EMBL:AFZ77109.1}; DE SubName: Full=Resolvase-like protein {ECO:0000313|EMBL:SXG19411.1}; DE SubName: Full=Site specific recombinase, DNA invertase {ECO:0000313|EMBL:AKS10512.1}; GN Name=resP {ECO:0000313|EMBL:ABY74391.1}; GN Synonyms=hin_3 {ECO:0000313|EMBL:SXG19411.1}, uvp-1 GN {ECO:0000313|EMBL:BAN17418.1}, uvp1 {ECO:0000313|EMBL:AIW55697.1}; GN ORFNames=GJJ08_027300 {ECO:0000313|EMBL:QOU54602.1}, GN SAMEA3499874_05327 {ECO:0000313|EMBL:SXG19411.1}, SAMEA3538828_05286 GN {ECO:0000313|EMBL:SYR48804.1}; OS Klebsiella pneumoniae. OG Plasmid 12 {ECO:0000313|EMBL:ACI62990.1}, OG Plasmid 9 {ECO:0000313|EMBL:ACI63186.1}, OG Plasmid p12247J {ECO:0000313|EMBL:AJR19483.1}, OG Plasmid pBK31551 {ECO:0000313|EMBL:AFZ77109.1}, OG Plasmid pIMP-1495 {ECO:0000313|EMBL:AIW55697.1}, OG Plasmid pK18An {ECO:0000313|EMBL:CCN80147.1}, OG Plasmid pK45-67VIM {ECO:0000313|EMBL:CDF32047.1, OG ECO:0000313|Proteomes:UP000464832}, OG Plasmid pKP96 {ECO:0000313|EMBL:ABY74391.1}, OG Plasmid pKPC-DK05 {ECO:0000313|EMBL:AKS10512.1}, OG Plasmid pKPI-6 {ECO:0000313|EMBL:BAM28997.1}, OG Plasmid pNDM-1saitama01 {ECO:0000313|EMBL:BAN17418.1}, OG Plasmid pNL194 {ECO:0000313|EMBL:ADG84865.1}, OG Plasmid pk18an {ECO:0000313|Proteomes:UP000464568}, and OG Plasmid unnamed1 {ECO:0000313|EMBL:QOU54602.1, OG ECO:0000313|Proteomes:UP000439817}. OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella. OX NCBI_TaxID=573 {ECO:0000313|EMBL:ABY74391.1}; RN [1] {ECO:0000313|EMBL:ABY74391.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=KP96 {ECO:0000313|EMBL:ABY74391.1}; RC PLASMID=pKP96 {ECO:0000313|EMBL:ABY74391.1}; RX PubMed=18812424; DOI=10.1093/jac/dkn397; RA Shen P., Jiang Y., Zhou Z., Zhang J., Yu Y., Li L.; RT "Complete nucleotide sequence of pKP96, a 67 850 bp multiresistance plasmid RT encoding qnrA1, aac(6')-Ib-cr and blaCTX-M-24 from Klebsiella pneumoniae."; RL J. Antimicrob. Chemother. 62:1252-1256(2008). RN [2] {ECO:0000313|EMBL:ACI62990.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=12 {ECO:0000313|EMBL:ACI62990.1}, and 9 RC {ECO:0000313|EMBL:ACI63186.1}; RC PLASMID=12 {ECO:0000313|EMBL:ACI62990.1}, and 9 RC {ECO:0000313|EMBL:ACI63186.1}; RX PubMed=19258268; DOI=10.1128/AAC.01355-08; RA Gootz T.D., Lescoe M.K., Dib-Hajj F., Dougherty B.A., He W., RA Della-Latta P., Huard R.C.; RT "Genetic organization of transposase regions surrounding blaKPC RT carbapenemase genes on plasmids from Klebsiella strains isolated in a New RT York City hospital."; RL Antimicrob. Agents Chemother. 53:1998-2004(2009). RN [3] {ECO:0000313|EMBL:ADG84865.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=NL194 {ECO:0000313|EMBL:ADG84865.1}; RC PLASMID=pNL194 {ECO:0000313|EMBL:ADG84865.1}; RX PubMed=20660690; DOI=10.1128/AAC.00665-10; RA Miriagou V., Papagiannitsis C.C., Kotsakis S.D., Loli A., Tzelepi E., RA Legakis N.J., Tzouvelekis L.S.; RT "Sequence of pNL194, a 79.3-Kilobase IncN Plasmid Carrying the blaVIM-1 RT Metallo-{beta}-Lactamase Gene in Klebsiella pneumoniae."; RL Antimicrob. Agents Chemother. 54:4497-4502(2010). RN [4] {ECO:0000313|EMBL:BAM28997.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=A26 {ECO:0000313|EMBL:BAM28997.1}; RC PLASMID=pKPI-6 {ECO:0000313|EMBL:BAM28997.1}; RX PubMed=22078906; DOI=10.1016/j.diagmicrobio.2011.09.019; RA Shigemoto N., Kuwahara R., Kayama S., Shimizu W., Onodera M., Yokozaki M., RA Hisatsune J., Kato F., Ohge H., Sugai M.; RT "Emergence in Japan of an imipenem-susceptible, meropenem-resistant RT Klebsiella pneumoniae carrying blaIMP-6."; RL Diagn. Microbiol. Infect. Dis. 72:109-112(2012). RN [5] {ECO:0000313|EMBL:CCN80147.1, ECO:0000313|Proteomes:UP000464568} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K18An {ECO:0000313|EMBL:CCN80147.1, RC ECO:0000313|Proteomes:UP000464568}; RC PLASMID=pK18An {ECO:0000313|EMBL:CCN80147.1}, and pk18an, strain k18an RC {ECO:0000313|Proteomes:UP000464568}; RA Le V.; RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000313|EMBL:AFZ77109.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BK31551 {ECO:0000313|EMBL:AFZ77109.1}; RC PLASMID=pBK31551 {ECO:0000313|EMBL:AFZ77109.1}; RX PubMed=23114770; DOI=10.1128/AAC.01648-12; RA Chen L., Chavda K.D., Fraimow H.S., Mediavilla J.R., Melano R.G., RA Jacobs M.R., Bonomo R.A., Kreiswirth B.N.; RT "Complete Nucleotide Sequences of blaKPC-4- and blaKPC-5-Harboring IncN and RT IncX Plasmids from Klebsiella pneumoniae Strains Isolated in New Jersey."; RL Antimicrob. Agents Chemother. 57:269-276(2013). RN [7] {ECO:0000313|EMBL:BAN17418.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=NDM-1saitama01 {ECO:0000313|EMBL:BAN17418.1}; RC PLASMID=pNDM-1saitama01 {ECO:0000313|EMBL:BAN17418.1}; RX PubMed=23681270; DOI=10.1093/jac/dkt190; RA Hishinuma A., Yoshida A., Suzuki H., Okuzumi K., Ishida T.; RT "Complete sequencing of an IncFII NDM-1 plasmid in Klebsiella pneumoniae RT shows structural features shared with other multidrug resistance RT plasmids."; RL J. Antimicrob. Chemother. 68:2415-2417(2013). RN [8] {ECO:0000313|EMBL:CCN80147.1, ECO:0000313|Proteomes:UP000464568} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K18An {ECO:0000313|EMBL:CCN80147.1, RC ECO:0000313|Proteomes:UP000464568}; RC PLASMID=pK18An {ECO:0000313|EMBL:CCN80147.1}, and pk18an, strain k18an RC {ECO:0000313|Proteomes:UP000464568}; RA Le T.M.V., Nguyen T.K.N., Campbell J.I., Schultsz C., Cerdeno-Tarraga A.M., RA Thomson N.R., Farrar J.J., Baker S.; RT "Annotation of 3 multi-drug resistance qnrS1 harbouring plasmids and a RT widespread of qnrS1-containing transposons circulating in RT Enterobacteriaceae in Ho Chi Minh City, Vietnam."; RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:CDF32047.1, ECO:0000313|Proteomes:UP000464832} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K45-67 {ECO:0000313|EMBL:CDF32047.1, RC ECO:0000313|Proteomes:UP000464832}; RC PLASMID=pK45-67VIM {ECO:0000313|EMBL:CDF32047.1, RC ECO:0000313|Proteomes:UP000464832}; RA Naseer U.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [10] {ECO:0000313|EMBL:CDF32047.1, ECO:0000313|Proteomes:UP000464832} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K45-67 {ECO:0000313|EMBL:CDF32047.1, RC ECO:0000313|Proteomes:UP000464832}; RC PLASMID=pK45-67VIM {ECO:0000313|EMBL:CDF32047.1, RC ECO:0000313|Proteomes:UP000464832}; RA Cantas L.C., Samuelsen O.S., Naseer U.N., Sundsfjord A.S., Sorum H.S.; RT "Impact of the host and medical treatment on the transfer of a blaVIM-1 RT IncN plasmid in an in vivo zebrafish gut model."; RL Submitted (JUN-2013) to the EMBL/GenBank/DDBJ databases. RN [11] {ECO:0000313|EMBL:AJR19483.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=27243D {ECO:0000313|EMBL:AJR19483.1}; RC PLASMID=p12247J {ECO:0000313|EMBL:AJR19483.1}; RA Farrell S.E., Mendes R.E., Jones R.N.; RT "Characterization of plasmid mediated KPC-2 and IMP-4 carbapenemases in a RT Klebsiella pneumonia isolate from China."; RL Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases. RN [12] {ECO:0000313|EMBL:AIW55697.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=CRE1495 {ECO:0000313|EMBL:AIW55697.1}; RC PLASMID=pIMP-1495 {ECO:0000313|EMBL:AIW55697.1}; RA Ho P.L., Wang Y., Lo W.U., Law P.Y.T., Liu C.J., Chow K.H., Lai E.L.; RT "Complete Sequence of an IncN Plasmid, pIMP-1495, Carrying blaIMP-4 in a RT Klebsiella pneumoniae Strain."; RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases. RN [13] {ECO:0000313|EMBL:AKS10512.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=KPC-DK05 {ECO:0000313|EMBL:AKS10512.1}; RC PLASMID=pKPC-DK05 {ECO:0000313|EMBL:AKS10512.1}; RA Kim S.Y.; RT "Complete sequence of a blaKPC-2-harbouring IncN2-type plasmid from RT Klebsiella pneumoniae in Korea."; RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases. RN [14] {ECO:0000313|Proteomes:UP000257587, ECO:0000313|Proteomes:UP000258253} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=EuSCAPE_AT002 {ECO:0000313|EMBL:SXG19411.1, RC ECO:0000313|Proteomes:UP000257587}, and EuSCAPE_HU047 RC {ECO:0000313|EMBL:SYR48804.1, ECO:0000313|Proteomes:UP000258253}; RG Pathogen Informatics; RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases. RN [15] {ECO:0000313|EMBL:QOU54602.1, ECO:0000313|Proteomes:UP000439817} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CriePir120 {ECO:0000313|EMBL:QOU54602.1, RC ECO:0000313|Proteomes:UP000439817}; RC PLASMID=unnamed1 {ECO:0000313|EMBL:QOU54602.1, RC ECO:0000313|Proteomes:UP000439817}; RX PubMed=32429555; RA Shelenkov A., Mikhaylova Y., Yanushevich Y., Samoilov A., Petrova L., RA Fomina V., Gusarov V., Zamyatin M., Shagin D., Akimkin V.; RT "Molecular Typing, Characterization of Antimicrobial Resistance, Virulence RT Profiling and Analysis of Whole-Genome Sequence of Clinical Klebsiella RT pneumoniae Isolates."; RL Antibiotics 9:0-E261(2020). CC -!- SIMILARITY: Belongs to the site-specific recombinase resolvase family. CC {ECO:0000256|ARBA:ARBA00009913}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; EU195449; ABY74391.1; -; Genomic_DNA. DR EMBL; FJ223605; ACI62990.1; -; Genomic_DNA. DR EMBL; FJ223607; ACI63186.1; -; Genomic_DNA. DR EMBL; GU585907; ADG84865.1; -; Genomic_DNA. DR EMBL; JX193301; AFZ77109.1; -; Genomic_DNA. DR EMBL; KM977631; AIW55697.1; -; Genomic_DNA. DR EMBL; KF680003; AJR19483.1; -; Genomic_DNA. DR EMBL; KR091915; AKS10512.1; -; Genomic_DNA. DR EMBL; AB616660; BAM28997.1; -; Genomic_DNA. DR EMBL; AB759690; BAN17418.1; -; Genomic_DNA. DR EMBL; HF545435; CCN80147.1; -; Genomic_DNA. DR EMBL; HF955507; CDF32047.1; -; Genomic_DNA. DR EMBL; CP063009; QOU54602.1; -; Genomic_DNA. DR EMBL; UKAW01000052; SXG19411.1; -; Genomic_DNA. DR EMBL; ULCI01000069; SYR48804.1; -; Genomic_DNA. DR RefSeq; WP_001749988.1; NZ_WXZN01000026.1. DR RefSeq; YP_002286838.1; NC_011383.1. DR RefSeq; YP_002286932.1; NC_011385.1. DR RefSeq; YP_002332849.1; NC_011617.1. DR RefSeq; YP_003813096.1; NC_014368.1. DR RefSeq; YP_007195370.1; NC_019888.1. DR RefSeq; YP_007349714.1; NC_020088.1. DR RefSeq; YP_007936884.1; NC_021180.1. DR RefSeq; YP_008145015.1; NC_021622.1. DR EnsemblBacteria; PAX10020; PAX10020; BVX91_28505. DR EnsemblBacteria; PVW83475; PVW83475; B4U30_07675. DR EnsemblBacteria; RDT64563; RDT64563; DXF97_28360. DR EnsemblBacteria; SBY90392; SBY90392; SAMEA3531848_05737. DR EnsemblBacteria; SSG41191; SSG41191; SAMEA23986918_09752. DR GeneID; 72530330; -. DR KEGG; kpb:FH42_26845; -. DR PATRIC; fig|573.1352.peg.5296; -. DR Proteomes; UP000257587; Unassembled WGS sequence. DR Proteomes; UP000258253; Unassembled WGS sequence. DR Proteomes; UP000439817; Plasmid unnamed1. DR Proteomes; UP000464568; Plasmid pk18an, strain k18an. DR Proteomes; UP000464832; Plasmid pK45-67VIM. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0000150; F:DNA strand exchange activity; IEA:InterPro. DR GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW. DR CDD; cd00569; HTH_Hin_like; 1. DR CDD; cd03768; SR_ResInv; 1. DR Gene3D; 1.10.10.60; Homeodomain-like; 1. DR Gene3D; 3.40.50.1390; Resolvase, N-terminal catalytic domain; 1. DR InterPro; IPR009057; Homeobox-like_sf. DR InterPro; IPR006118; Recombinase_CS. DR InterPro; IPR006119; Resolv_N. DR InterPro; IPR036162; Resolvase-like_N_sf. DR InterPro; IPR006120; Resolvase_HTH_dom. DR PANTHER; PTHR30461; DNA-INVERTASE FROM LAMBDOID PROPHAGE; 1. DR PANTHER; PTHR30461:SF22; SERINE RECOMBINASE PINE-RELATED; 1. DR Pfam; PF02796; HTH_7; 1. DR Pfam; PF00239; Resolvase; 1. DR SMART; SM00857; Resolvase; 1. DR SUPFAM; SSF46689; Homeodomain-like; 1. DR SUPFAM; SSF53041; Resolvase-like; 1. DR PROSITE; PS00398; RECOMBINASES_2; 1. DR PROSITE; PS51736; RECOMBINASES_3; 1. PE 3: Inferred from homology; KW DNA integration {ECO:0000256|ARBA:ARBA00022908}; KW DNA recombination {ECO:0000256|ARBA:ARBA00023172}; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125}; KW Plasmid {ECO:0000313|EMBL:ABY74391.1}. FT DOMAIN 1..140 FT /note="Resolvase/invertase-type recombinase catalytic" FT /evidence="ECO:0000259|PROSITE:PS51736" FT ACT_SITE 9 FT /note="O-(5'-phospho-DNA)-serine intermediate" FT /evidence="ECO:0000256|PIRSR:PIRSR606118-50" SQ SEQUENCE 189 AA; 21131 MW; 5388132D1ABF5A5A CRC64; MKIGYARKST HLQDVAHQVD ELTKAGCEQI YQDQTSRSGP KRDKKGAPEL ENCLKALREG DTLVVWALDR LGGSLGQVIT LLDDLKKRGI TFIAIKDRID TNAPVIGEIY THLMAIFSSF ERNRNIERTR SGLAAARARG RVGGRKPSLS EEDVKQIRIL LADPEMTVGA VAKRFNVSRM TIYRYTTKS //