ID   B6RFL1_KLEPN            Unreviewed;       189 AA.
AC   B6RFL1;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   SubName: Full=Conserved domain protein {ECO:0000313|EMBL:ACI63186.1};
DE   SubName: Full=MPF resolvase Uvp1 for plasmid R46 {ECO:0000313|EMBL:CDF32047.1};
DE   SubName: Full=Recombinase family protein {ECO:0000313|EMBL:QOU54602.1};
DE   SubName: Full=Resolvase {ECO:0000313|EMBL:ABY74391.1};
DE   SubName: Full=Resolvase Uvp1 {ECO:0000313|EMBL:AFZ77109.1};
DE   SubName: Full=Resolvase-like protein {ECO:0000313|EMBL:SXG19411.1};
DE   SubName: Full=Site specific recombinase, DNA invertase {ECO:0000313|EMBL:AKS10512.1};
GN   Name=resP {ECO:0000313|EMBL:ABY74391.1};
GN   Synonyms=hin_3 {ECO:0000313|EMBL:SXG19411.1}, uvp-1
GN   {ECO:0000313|EMBL:BAN17418.1}, uvp1 {ECO:0000313|EMBL:AIW55697.1};
GN   ORFNames=GJJ08_027300 {ECO:0000313|EMBL:QOU54602.1},
GN   SAMEA3499874_05327 {ECO:0000313|EMBL:SXG19411.1}, SAMEA3538828_05286
GN   {ECO:0000313|EMBL:SYR48804.1};
OS   Klebsiella pneumoniae.
OG   Plasmid 12 {ECO:0000313|EMBL:ACI62990.1},
OG   Plasmid 9 {ECO:0000313|EMBL:ACI63186.1},
OG   Plasmid p12247J {ECO:0000313|EMBL:AJR19483.1},
OG   Plasmid pBK31551 {ECO:0000313|EMBL:AFZ77109.1},
OG   Plasmid pIMP-1495 {ECO:0000313|EMBL:AIW55697.1},
OG   Plasmid pK18An {ECO:0000313|EMBL:CCN80147.1},
OG   Plasmid pK45-67VIM {ECO:0000313|EMBL:CDF32047.1,
OG   ECO:0000313|Proteomes:UP000464832},
OG   Plasmid pKP96 {ECO:0000313|EMBL:ABY74391.1},
OG   Plasmid pKPC-DK05 {ECO:0000313|EMBL:AKS10512.1},
OG   Plasmid pKPI-6 {ECO:0000313|EMBL:BAM28997.1},
OG   Plasmid pNDM-1saitama01 {ECO:0000313|EMBL:BAN17418.1},
OG   Plasmid pNL194 {ECO:0000313|EMBL:ADG84865.1},
OG   Plasmid pk18an {ECO:0000313|Proteomes:UP000464568}, and
OG   Plasmid unnamed1 {ECO:0000313|EMBL:QOU54602.1,
OG   ECO:0000313|Proteomes:UP000439817}.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=573 {ECO:0000313|EMBL:ABY74391.1};
RN   [1] {ECO:0000313|EMBL:ABY74391.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=KP96 {ECO:0000313|EMBL:ABY74391.1};
RC   PLASMID=pKP96 {ECO:0000313|EMBL:ABY74391.1};
RX   PubMed=18812424; DOI=10.1093/jac/dkn397;
RA   Shen P., Jiang Y., Zhou Z., Zhang J., Yu Y., Li L.;
RT   "Complete nucleotide sequence of pKP96, a 67 850 bp multiresistance plasmid
RT   encoding qnrA1, aac(6')-Ib-cr and blaCTX-M-24 from Klebsiella pneumoniae.";
RL   J. Antimicrob. Chemother. 62:1252-1256(2008).
RN   [2] {ECO:0000313|EMBL:ACI62990.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=12 {ECO:0000313|EMBL:ACI62990.1}, and 9
RC   {ECO:0000313|EMBL:ACI63186.1};
RC   PLASMID=12 {ECO:0000313|EMBL:ACI62990.1}, and 9
RC   {ECO:0000313|EMBL:ACI63186.1};
RX   PubMed=19258268; DOI=10.1128/AAC.01355-08;
RA   Gootz T.D., Lescoe M.K., Dib-Hajj F., Dougherty B.A., He W.,
RA   Della-Latta P., Huard R.C.;
RT   "Genetic organization of transposase regions surrounding blaKPC
RT   carbapenemase genes on plasmids from Klebsiella strains isolated in a New
RT   York City hospital.";
RL   Antimicrob. Agents Chemother. 53:1998-2004(2009).
RN   [3] {ECO:0000313|EMBL:ADG84865.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NL194 {ECO:0000313|EMBL:ADG84865.1};
RC   PLASMID=pNL194 {ECO:0000313|EMBL:ADG84865.1};
RX   PubMed=20660690; DOI=10.1128/AAC.00665-10;
RA   Miriagou V., Papagiannitsis C.C., Kotsakis S.D., Loli A., Tzelepi E.,
RA   Legakis N.J., Tzouvelekis L.S.;
RT   "Sequence of pNL194, a 79.3-Kilobase IncN Plasmid Carrying the blaVIM-1
RT   Metallo-{beta}-Lactamase Gene in Klebsiella pneumoniae.";
RL   Antimicrob. Agents Chemother. 54:4497-4502(2010).
RN   [4] {ECO:0000313|EMBL:BAM28997.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=A26 {ECO:0000313|EMBL:BAM28997.1};
RC   PLASMID=pKPI-6 {ECO:0000313|EMBL:BAM28997.1};
RX   PubMed=22078906; DOI=10.1016/j.diagmicrobio.2011.09.019;
RA   Shigemoto N., Kuwahara R., Kayama S., Shimizu W., Onodera M., Yokozaki M.,
RA   Hisatsune J., Kato F., Ohge H., Sugai M.;
RT   "Emergence in Japan of an imipenem-susceptible, meropenem-resistant
RT   Klebsiella pneumoniae carrying blaIMP-6.";
RL   Diagn. Microbiol. Infect. Dis. 72:109-112(2012).
RN   [5] {ECO:0000313|EMBL:CCN80147.1, ECO:0000313|Proteomes:UP000464568}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K18An {ECO:0000313|EMBL:CCN80147.1,
RC   ECO:0000313|Proteomes:UP000464568};
RC   PLASMID=pK18An {ECO:0000313|EMBL:CCN80147.1}, and pk18an, strain k18an
RC   {ECO:0000313|Proteomes:UP000464568};
RA   Le V.;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:AFZ77109.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BK31551 {ECO:0000313|EMBL:AFZ77109.1};
RC   PLASMID=pBK31551 {ECO:0000313|EMBL:AFZ77109.1};
RX   PubMed=23114770; DOI=10.1128/AAC.01648-12;
RA   Chen L., Chavda K.D., Fraimow H.S., Mediavilla J.R., Melano R.G.,
RA   Jacobs M.R., Bonomo R.A., Kreiswirth B.N.;
RT   "Complete Nucleotide Sequences of blaKPC-4- and blaKPC-5-Harboring IncN and
RT   IncX Plasmids from Klebsiella pneumoniae Strains Isolated in New Jersey.";
RL   Antimicrob. Agents Chemother. 57:269-276(2013).
RN   [7] {ECO:0000313|EMBL:BAN17418.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NDM-1saitama01 {ECO:0000313|EMBL:BAN17418.1};
RC   PLASMID=pNDM-1saitama01 {ECO:0000313|EMBL:BAN17418.1};
RX   PubMed=23681270; DOI=10.1093/jac/dkt190;
RA   Hishinuma A., Yoshida A., Suzuki H., Okuzumi K., Ishida T.;
RT   "Complete sequencing of an IncFII NDM-1 plasmid in Klebsiella pneumoniae
RT   shows structural features shared with other multidrug resistance
RT   plasmids.";
RL   J. Antimicrob. Chemother. 68:2415-2417(2013).
RN   [8] {ECO:0000313|EMBL:CCN80147.1, ECO:0000313|Proteomes:UP000464568}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K18An {ECO:0000313|EMBL:CCN80147.1,
RC   ECO:0000313|Proteomes:UP000464568};
RC   PLASMID=pK18An {ECO:0000313|EMBL:CCN80147.1}, and pk18an, strain k18an
RC   {ECO:0000313|Proteomes:UP000464568};
RA   Le T.M.V., Nguyen T.K.N., Campbell J.I., Schultsz C., Cerdeno-Tarraga A.M.,
RA   Thomson N.R., Farrar J.J., Baker S.;
RT   "Annotation of 3 multi-drug resistance qnrS1 harbouring plasmids and a
RT   widespread of qnrS1-containing transposons circulating in
RT   Enterobacteriaceae in Ho Chi Minh City, Vietnam.";
RL   Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
RN   [9] {ECO:0000313|EMBL:CDF32047.1, ECO:0000313|Proteomes:UP000464832}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K45-67 {ECO:0000313|EMBL:CDF32047.1,
RC   ECO:0000313|Proteomes:UP000464832};
RC   PLASMID=pK45-67VIM {ECO:0000313|EMBL:CDF32047.1,
RC   ECO:0000313|Proteomes:UP000464832};
RA   Naseer U.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [10] {ECO:0000313|EMBL:CDF32047.1, ECO:0000313|Proteomes:UP000464832}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K45-67 {ECO:0000313|EMBL:CDF32047.1,
RC   ECO:0000313|Proteomes:UP000464832};
RC   PLASMID=pK45-67VIM {ECO:0000313|EMBL:CDF32047.1,
RC   ECO:0000313|Proteomes:UP000464832};
RA   Cantas L.C., Samuelsen O.S., Naseer U.N., Sundsfjord A.S., Sorum H.S.;
RT   "Impact of the host and medical treatment on the transfer of a blaVIM-1
RT   IncN plasmid in an in vivo zebrafish gut model.";
RL   Submitted (JUN-2013) to the EMBL/GenBank/DDBJ databases.
RN   [11] {ECO:0000313|EMBL:AJR19483.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=27243D {ECO:0000313|EMBL:AJR19483.1};
RC   PLASMID=p12247J {ECO:0000313|EMBL:AJR19483.1};
RA   Farrell S.E., Mendes R.E., Jones R.N.;
RT   "Characterization of plasmid mediated KPC-2 and IMP-4 carbapenemases in a
RT   Klebsiella pneumonia isolate from China.";
RL   Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
RN   [12] {ECO:0000313|EMBL:AIW55697.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CRE1495 {ECO:0000313|EMBL:AIW55697.1};
RC   PLASMID=pIMP-1495 {ECO:0000313|EMBL:AIW55697.1};
RA   Ho P.L., Wang Y., Lo W.U., Law P.Y.T., Liu C.J., Chow K.H., Lai E.L.;
RT   "Complete Sequence of an IncN Plasmid, pIMP-1495, Carrying blaIMP-4 in a
RT   Klebsiella pneumoniae Strain.";
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
RN   [13] {ECO:0000313|EMBL:AKS10512.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=KPC-DK05 {ECO:0000313|EMBL:AKS10512.1};
RC   PLASMID=pKPC-DK05 {ECO:0000313|EMBL:AKS10512.1};
RA   Kim S.Y.;
RT   "Complete sequence of a blaKPC-2-harbouring IncN2-type plasmid from
RT   Klebsiella pneumoniae in Korea.";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN   [14] {ECO:0000313|Proteomes:UP000257587, ECO:0000313|Proteomes:UP000258253}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EuSCAPE_AT002 {ECO:0000313|EMBL:SXG19411.1,
RC   ECO:0000313|Proteomes:UP000257587}, and EuSCAPE_HU047
RC   {ECO:0000313|EMBL:SYR48804.1, ECO:0000313|Proteomes:UP000258253};
RG   Pathogen Informatics;
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
RN   [15] {ECO:0000313|EMBL:QOU54602.1, ECO:0000313|Proteomes:UP000439817}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CriePir120 {ECO:0000313|EMBL:QOU54602.1,
RC   ECO:0000313|Proteomes:UP000439817};
RC   PLASMID=unnamed1 {ECO:0000313|EMBL:QOU54602.1,
RC   ECO:0000313|Proteomes:UP000439817};
RX   PubMed=32429555;
RA   Shelenkov A., Mikhaylova Y., Yanushevich Y., Samoilov A., Petrova L.,
RA   Fomina V., Gusarov V., Zamyatin M., Shagin D., Akimkin V.;
RT   "Molecular Typing, Characterization of Antimicrobial Resistance, Virulence
RT   Profiling and Analysis of Whole-Genome Sequence of Clinical Klebsiella
RT   pneumoniae Isolates.";
RL   Antibiotics 9:0-E261(2020).
CC   -!- SIMILARITY: Belongs to the site-specific recombinase resolvase family.
CC       {ECO:0000256|ARBA:ARBA00009913}.
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DR   EMBL; EU195449; ABY74391.1; -; Genomic_DNA.
DR   EMBL; FJ223605; ACI62990.1; -; Genomic_DNA.
DR   EMBL; FJ223607; ACI63186.1; -; Genomic_DNA.
DR   EMBL; GU585907; ADG84865.1; -; Genomic_DNA.
DR   EMBL; JX193301; AFZ77109.1; -; Genomic_DNA.
DR   EMBL; KM977631; AIW55697.1; -; Genomic_DNA.
DR   EMBL; KF680003; AJR19483.1; -; Genomic_DNA.
DR   EMBL; KR091915; AKS10512.1; -; Genomic_DNA.
DR   EMBL; AB616660; BAM28997.1; -; Genomic_DNA.
DR   EMBL; AB759690; BAN17418.1; -; Genomic_DNA.
DR   EMBL; HF545435; CCN80147.1; -; Genomic_DNA.
DR   EMBL; HF955507; CDF32047.1; -; Genomic_DNA.
DR   EMBL; CP063009; QOU54602.1; -; Genomic_DNA.
DR   EMBL; UKAW01000052; SXG19411.1; -; Genomic_DNA.
DR   EMBL; ULCI01000069; SYR48804.1; -; Genomic_DNA.
DR   RefSeq; WP_001749988.1; NZ_WXZN01000026.1.
DR   RefSeq; YP_002286838.1; NC_011383.1.
DR   RefSeq; YP_002286932.1; NC_011385.1.
DR   RefSeq; YP_002332849.1; NC_011617.1.
DR   RefSeq; YP_003813096.1; NC_014368.1.
DR   RefSeq; YP_007195370.1; NC_019888.1.
DR   RefSeq; YP_007349714.1; NC_020088.1.
DR   RefSeq; YP_007936884.1; NC_021180.1.
DR   RefSeq; YP_008145015.1; NC_021622.1.
DR   EnsemblBacteria; PAX10020; PAX10020; BVX91_28505.
DR   EnsemblBacteria; PVW83475; PVW83475; B4U30_07675.
DR   EnsemblBacteria; RDT64563; RDT64563; DXF97_28360.
DR   EnsemblBacteria; SBY90392; SBY90392; SAMEA3531848_05737.
DR   EnsemblBacteria; SSG41191; SSG41191; SAMEA23986918_09752.
DR   GeneID; 58391949; -.
DR   KEGG; kpb:FH42_26845; -.
DR   PATRIC; fig|573.1352.peg.5296; -.
DR   Proteomes; UP000257587; Unassembled WGS sequence.
DR   Proteomes; UP000258253; Unassembled WGS sequence.
DR   Proteomes; UP000439817; Plasmid unnamed1.
DR   Proteomes; UP000464568; Plasmid pk18an, strain k18an.
DR   Proteomes; UP000464832; Plasmid pK45-67VIM.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000150; F:DNA strand exchange activity; IEA:InterPro.
DR   GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1390; -; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR006118; Recombinase_CS.
DR   InterPro; IPR006119; Resolv_N.
DR   InterPro; IPR036162; Resolvase-like_N_sf.
DR   InterPro; IPR006120; Resolvase_HTH_dom.
DR   Pfam; PF02796; HTH_7; 1.
DR   Pfam; PF00239; Resolvase; 1.
DR   SMART; SM00857; Resolvase; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF53041; SSF53041; 1.
DR   PROSITE; PS00398; RECOMBINASES_2; 1.
DR   PROSITE; PS51736; RECOMBINASES_3; 1.
PE   3: Inferred from homology;
KW   DNA integration {ECO:0000256|ARBA:ARBA00022908};
KW   DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Plasmid {ECO:0000313|EMBL:ABY74391.1}.
FT   DOMAIN          1..140
FT                   /note="Resolvase/invertase-type recombinase catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS51736"
FT   ACT_SITE        9
FT                   /note="O-(5'-phospho-DNA)-serine intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR606118-50"
SQ   SEQUENCE   189 AA;  21131 MW;  5388132D1ABF5A5A CRC64;
     MKIGYARKST HLQDVAHQVD ELTKAGCEQI YQDQTSRSGP KRDKKGAPEL ENCLKALREG
     DTLVVWALDR LGGSLGQVIT LLDDLKKRGI TFIAIKDRID TNAPVIGEIY THLMAIFSSF
     ERNRNIERTR SGLAAARARG RVGGRKPSLS EEDVKQIRIL LADPEMTVGA VAKRFNVSRM
     TIYRYTTKS
//