ID   B6RFL1_KLEPN            Unreviewed;       189 AA.
AC   B6RFL1;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 1.
DT   10-FEB-2021, entry version 89.
DE   SubName: Full=Conserved domain protein {ECO:0000313|EMBL:ACI63186.1};
DE   SubName: Full=MPF resolvase Uvp1 for plasmid R46 {ECO:0000313|EMBL:CDF32047.1};
DE   SubName: Full=Recombinase family protein {ECO:0000313|EMBL:AUU98573.1};
DE   SubName: Full=Resolvase {ECO:0000313|EMBL:ABY74391.1};
DE   SubName: Full=Resolvase Uvp1 {ECO:0000313|EMBL:AFZ77109.1};
DE   SubName: Full=Site specific recombinase, DNA invertase {ECO:0000313|EMBL:AKS10512.1};
GN   Name=resP {ECO:0000313|EMBL:ABY74391.1};
GN   Synonyms=uvp-1 {ECO:0000313|EMBL:BAN17418.1}, uvp1
GN   {ECO:0000313|EMBL:AIW55697.1};
GN   ORFNames=BVX91_28505 {ECO:0000313|EMBL:PAX10020.1}, C2U49_28070
GN   {ECO:0000313|EMBL:AUU98573.1}, C2U49_29380
GN   {ECO:0000313|EMBL:AUU98789.1}, WP4S18C04_P30500
GN   {ECO:0000313|EMBL:BBR80893.1};
OS   Klebsiella pneumoniae.
OG   Plasmid 12 {ECO:0000313|EMBL:ACI62990.1},
OG   Plasmid 9 {ECO:0000313|EMBL:ACI63186.1},
OG   Plasmid p12247J {ECO:0000313|EMBL:AJR19483.1},
OG   Plasmid pBK31551 {ECO:0000313|EMBL:AFZ77109.1},
OG   Plasmid pIMP-1495 {ECO:0000313|EMBL:AIW55697.1},
OG   Plasmid pK18An {ECO:0000313|EMBL:CCN80147.1},
OG   Plasmid pK45-67VIM {ECO:0000313|EMBL:CDF32047.1,
OG   ECO:0000313|Proteomes:UP000464832},
OG   Plasmid pKP96 {ECO:0000313|EMBL:ABY74391.1},
OG   Plasmid pKPC-224e {ECO:0000313|EMBL:AUU98573.1},
OG   Plasmid pKPC-DK05 {ECO:0000313|EMBL:AKS10512.1},
OG   Plasmid pKPI-6 {ECO:0000313|EMBL:BAM28997.1},
OG   Plasmid pKPN-9729 {ECO:0000313|EMBL:AUU98789.1},
OG   Plasmid pNDM-1saitama01 {ECO:0000313|EMBL:BAN17418.1},
OG   Plasmid pNL194 {ECO:0000313|EMBL:ADG84865.1},
OG   Plasmid pWP4-S18-CRE-04_3 {ECO:0000313|EMBL:BBR80893.1,
OG   ECO:0000313|Proteomes:UP000515327},
OG   Plasmid pk18an {ECO:0000313|Proteomes:UP000464568},
OG   Plasmid pkpc-224e {ECO:0000313|Proteomes:UP000236255}, and
OG   Plasmid pkpn-9729 {ECO:0000313|Proteomes:UP000236255}.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella.
OX   NCBI_TaxID=573 {ECO:0000313|EMBL:ABY74391.1};
RN   [1] {ECO:0000313|EMBL:ABY74391.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=KP96 {ECO:0000313|EMBL:ABY74391.1};
RC   PLASMID=pKP96 {ECO:0000313|EMBL:ABY74391.1};
RX   PubMed=18812424; DOI=10.1093/jac/dkn397;
RA   Shen P., Jiang Y., Zhou Z., Zhang J., Yu Y., Li L.;
RT   "Complete nucleotide sequence of pKP96, a 67 850 bp multiresistance plasmid
RT   encoding qnrA1, aac(6')-Ib-cr and blaCTX-M-24 from Klebsiella pneumoniae.";
RL   J. Antimicrob. Chemother. 62:1252-1256(2008).
RN   [2] {ECO:0000313|EMBL:ACI62990.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=12 {ECO:0000313|EMBL:ACI62990.1}, and 9
RC   {ECO:0000313|EMBL:ACI63186.1};
RC   PLASMID=12 {ECO:0000313|EMBL:ACI62990.1}, and 9
RC   {ECO:0000313|EMBL:ACI63186.1};
RX   PubMed=19258268; DOI=10.1128/AAC.01355-08;
RA   Gootz T.D., Lescoe M.K., Dib-Hajj F., Dougherty B.A., He W.,
RA   Della-Latta P., Huard R.C.;
RT   "Genetic organization of transposase regions surrounding blaKPC
RT   carbapenemase genes on plasmids from Klebsiella strains isolated in a New
RT   York City hospital.";
RL   Antimicrob. Agents Chemother. 53:1998-2004(2009).
RN   [3] {ECO:0000313|EMBL:ADG84865.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NL194 {ECO:0000313|EMBL:ADG84865.1};
RC   PLASMID=pNL194 {ECO:0000313|EMBL:ADG84865.1};
RX   PubMed=20660690; DOI=10.1128/AAC.00665-10;
RA   Miriagou V., Papagiannitsis C.C., Kotsakis S.D., Loli A., Tzelepi E.,
RA   Legakis N.J., Tzouvelekis L.S.;
RT   "Sequence of pNL194, a 79.3-Kilobase IncN Plasmid Carrying the blaVIM-1
RT   Metallo-{beta}-Lactamase Gene in Klebsiella pneumoniae.";
RL   Antimicrob. Agents Chemother. 54:4497-4502(2010).
RN   [4] {ECO:0000313|EMBL:BAM28997.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=A26 {ECO:0000313|EMBL:BAM28997.1};
RC   PLASMID=pKPI-6 {ECO:0000313|EMBL:BAM28997.1};
RX   PubMed=22078906; DOI=10.1016/j.diagmicrobio.2011.09.019;
RA   Shigemoto N., Kuwahara R., Kayama S., Shimizu W., Onodera M., Yokozaki M.,
RA   Hisatsune J., Kato F., Ohge H., Sugai M.;
RT   "Emergence in Japan of an imipenem-susceptible, meropenem-resistant
RT   Klebsiella pneumoniae carrying blaIMP-6.";
RL   Diagn. Microbiol. Infect. Dis. 72:109-112(2012).
RN   [5] {ECO:0000313|EMBL:CCN80147.1, ECO:0000313|Proteomes:UP000464568}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K18An {ECO:0000313|EMBL:CCN80147.1,
RC   ECO:0000313|Proteomes:UP000464568};
RC   PLASMID=pK18An {ECO:0000313|EMBL:CCN80147.1}, and pk18an, strain k18an
RC   {ECO:0000313|Proteomes:UP000464568};
RA   Le V.;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:AFZ77109.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BK31551 {ECO:0000313|EMBL:AFZ77109.1};
RC   PLASMID=pBK31551 {ECO:0000313|EMBL:AFZ77109.1};
RX   PubMed=23114770; DOI=10.1128/AAC.01648-12;
RA   Chen L., Chavda K.D., Fraimow H.S., Mediavilla J.R., Melano R.G.,
RA   Jacobs M.R., Bonomo R.A., Kreiswirth B.N.;
RT   "Complete Nucleotide Sequences of blaKPC-4- and blaKPC-5-Harboring IncN and
RT   IncX Plasmids from Klebsiella pneumoniae Strains Isolated in New Jersey.";
RL   Antimicrob. Agents Chemother. 57:269-276(2013).
RN   [7] {ECO:0000313|EMBL:BAN17418.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NDM-1saitama01 {ECO:0000313|EMBL:BAN17418.1};
RC   PLASMID=pNDM-1saitama01 {ECO:0000313|EMBL:BAN17418.1};
RX   PubMed=23681270; DOI=10.1093/jac/dkt190;
RA   Hishinuma A., Yoshida A., Suzuki H., Okuzumi K., Ishida T.;
RT   "Complete sequencing of an IncFII NDM-1 plasmid in Klebsiella pneumoniae
RT   shows structural features shared with other multidrug resistance
RT   plasmids.";
RL   J. Antimicrob. Chemother. 68:2415-2417(2013).
RN   [8] {ECO:0000313|EMBL:CCN80147.1, ECO:0000313|Proteomes:UP000464568}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K18An {ECO:0000313|EMBL:CCN80147.1,
RC   ECO:0000313|Proteomes:UP000464568};
RC   PLASMID=pK18An {ECO:0000313|EMBL:CCN80147.1}, and pk18an, strain k18an
RC   {ECO:0000313|Proteomes:UP000464568};
RA   Le T.M.V., Nguyen T.K.N., Campbell J.I., Schultsz C., Cerdeno-Tarraga A.M.,
RA   Thomson N.R., Farrar J.J., Baker S.;
RT   "Annotation of 3 multi-drug resistance qnrS1 harbouring plasmids and a
RT   widespread of qnrS1-containing transposons circulating in
RT   Enterobacteriaceae in Ho Chi Minh City, Vietnam.";
RL   Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
RN   [9] {ECO:0000313|EMBL:CDF32047.1, ECO:0000313|Proteomes:UP000464832}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K45-67 {ECO:0000313|EMBL:CDF32047.1,
RC   ECO:0000313|Proteomes:UP000464832};
RC   PLASMID=pK45-67VIM {ECO:0000313|EMBL:CDF32047.1,
RC   ECO:0000313|Proteomes:UP000464832};
RA   Naseer U.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [10] {ECO:0000313|EMBL:CDF32047.1, ECO:0000313|Proteomes:UP000464832}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K45-67 {ECO:0000313|EMBL:CDF32047.1,
RC   ECO:0000313|Proteomes:UP000464832};
RC   PLASMID=pK45-67VIM {ECO:0000313|EMBL:CDF32047.1,
RC   ECO:0000313|Proteomes:UP000464832};
RA   Cantas L.C., Samuelsen O.S., Naseer U.N., Sundsfjord A.S., Sorum H.S.;
RT   "Impact of the host and medical treatment on the transfer of a blaVIM-1
RT   IncN plasmid in an in vivo zebrafish gut model.";
RL   Submitted (JUN-2013) to the EMBL/GenBank/DDBJ databases.
RN   [11] {ECO:0000313|EMBL:AJR19483.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=27243D {ECO:0000313|EMBL:AJR19483.1};
RC   PLASMID=p12247J {ECO:0000313|EMBL:AJR19483.1};
RA   Farrell S.E., Mendes R.E., Jones R.N.;
RT   "Characterization of plasmid mediated KPC-2 and IMP-4 carbapenemases in a
RT   Klebsiella pneumonia isolate from China.";
RL   Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
RN   [12] {ECO:0000313|EMBL:AIW55697.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CRE1495 {ECO:0000313|EMBL:AIW55697.1};
RC   PLASMID=pIMP-1495 {ECO:0000313|EMBL:AIW55697.1};
RA   Ho P.L., Wang Y., Lo W.U., Law P.Y.T., Liu C.J., Chow K.H., Lai E.L.;
RT   "Complete Sequence of an IncN Plasmid, pIMP-1495, Carrying blaIMP-4 in a
RT   Klebsiella pneumoniae Strain.";
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
RN   [13] {ECO:0000313|EMBL:AKS10512.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=KPC-DK05 {ECO:0000313|EMBL:AKS10512.1};
RC   PLASMID=pKPC-DK05 {ECO:0000313|EMBL:AKS10512.1};
RA   Kim S.Y.;
RT   "Complete sequence of a blaKPC-2-harbouring IncN2-type plasmid from
RT   Klebsiella pneumoniae in Korea.";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN   [14] {ECO:0000313|EMBL:PAX10020.1, ECO:0000313|Proteomes:UP000218240}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WBB417 {ECO:0000313|EMBL:PAX10020.1,
RC   ECO:0000313|Proteomes:UP000218240};
RA   Koh T.H., Abdul Rahman N., Teo J.W., La M.-V., Periaswamy B., Chen S.L.;
RT   "Draft Genome Sequence of a Singapore Klebsiella pneumoniae subsp.
RT   pnuemoniae isolate DS32358_14 Encoding the Carbapenemase Gene blaVIM-1.";
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
RN   [15] {ECO:0000313|Proteomes:UP000236255}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KPNIH49 {ECO:0000313|Proteomes:UP000236255};
RC   PLASMID=pkpc-224e {ECO:0000313|Proteomes:UP000236255}, and pkpn-9729
RC   {ECO:0000313|Proteomes:UP000236255};
RX   PubMed=29437920;
RG   NISC Comparative Sequencing Program;
RA   Weingarten R.A., Johnson R.C., Conlan S., Ramsburg A.M., Dekker J.P.,
RA   Lau A.F., Khil P., Odom R.T., Deming C., Park M., Thomas P.J.,
RA   Henderson D.K., Palmore T.N., Segre J.A., Frank K.M.;
RT   "Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of
RT   Bacterial Plasmids Conferring Carbapenem Resistance.";
RL   MBio 9:e02011-17(2018).
RN   [16] {ECO:0000313|EMBL:AUU98573.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=KPNIH49 {ECO:0000313|EMBL:AUU98573.1};
RC   PLASMID=pKPC-224e {ECO:0000313|EMBL:AUU98573.1}, and pKPN-9729
RC   {ECO:0000313|EMBL:AUU98789.1};
RG   NISC Comparative Sequencing Program;
RA   Weingarten R.A., Johnson R.C., Conlan S., Ramsburg A.M., Dekker J.P.,
RA   Lau A.F., Khil P., Odom R.T., Deming C., Park M., Thomas P.J.,
RA   Henderson D.K., Palmore T.N., Segre J.A., Frank K.M.;
RT   "Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of
RT   Bacterial Plasmids Conferring Carbapenem Resistance.";
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [17] {ECO:0000313|EMBL:AUU98573.1, ECO:0000313|Proteomes:UP000236255}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KPNIH49 {ECO:0000313|EMBL:AUU98573.1,
RC   ECO:0000313|Proteomes:UP000236255};
RC   PLASMID=pkpc-224e {ECO:0000313|Proteomes:UP000236255}, pKPC-224e
RC   {ECO:0000313|EMBL:AUU98573.1}, pkpn-9729
RC   {ECO:0000313|Proteomes:UP000236255}, and pKPN-9729
RC   {ECO:0000313|EMBL:AUU98789.1};
RA   Segre J.A., Mullikin J.;
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [18] {ECO:0000313|EMBL:BBR80893.1, ECO:0000313|Proteomes:UP000515327}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WP4-S18-CRE-04 {ECO:0000313|EMBL:BBR80893.1,
RC   ECO:0000313|Proteomes:UP000515327};
RC   PLASMID=pWP4-S18-CRE-04_3 {ECO:0000313|EMBL:BBR80893.1,
RC   ECO:0000313|Proteomes:UP000515327};
RA   Sekizuka T., Itokawa K., Yatsu K., Inamine Y., Kuroda M.;
RT   "complete genome sequences of Klebsiella pneumoniae str. WP4-S18-CRE-04
RT   isolated from wastewater treatment plant effluent.";
RL   Submitted (DEC-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the site-specific recombinase resolvase family.
CC       {ECO:0000256|ARBA:ARBA00009913}.
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DR   EMBL; EU195449; ABY74391.1; -; Genomic_DNA.
DR   EMBL; FJ223605; ACI62990.1; -; Genomic_DNA.
DR   EMBL; FJ223607; ACI63186.1; -; Genomic_DNA.
DR   EMBL; GU585907; ADG84865.1; -; Genomic_DNA.
DR   EMBL; JX193301; AFZ77109.1; -; Genomic_DNA.
DR   EMBL; KM977631; AIW55697.1; -; Genomic_DNA.
DR   EMBL; KF680003; AJR19483.1; -; Genomic_DNA.
DR   EMBL; KR091915; AKS10512.1; -; Genomic_DNA.
DR   EMBL; CP026179; AUU98573.1; -; Genomic_DNA.
DR   EMBL; CP026180; AUU98789.1; -; Genomic_DNA.
DR   EMBL; AB616660; BAM28997.1; -; Genomic_DNA.
DR   EMBL; AB759690; BAN17418.1; -; Genomic_DNA.
DR   EMBL; AP022081; BBR80893.1; -; Genomic_DNA.
DR   EMBL; HF545435; CCN80147.1; -; Genomic_DNA.
DR   EMBL; HF955507; CDF32047.1; -; Genomic_DNA.
DR   EMBL; NSMB01000092; PAX10020.1; -; Genomic_DNA.
DR   RefSeq; WP_001749988.1; NZ_WXZN01000026.1.
DR   RefSeq; YP_002286838.1; NC_011383.1.
DR   RefSeq; YP_002286932.1; NC_011385.1.
DR   RefSeq; YP_002332849.1; NC_011617.1.
DR   RefSeq; YP_003813096.1; NC_014368.1.
DR   RefSeq; YP_007195370.1; NC_019888.1.
DR   RefSeq; YP_007349714.1; NC_020088.1.
DR   RefSeq; YP_007936884.1; NC_021180.1.
DR   RefSeq; YP_008145015.1; NC_021622.1.
DR   EnsemblBacteria; SBY90392; SBY90392; SAMEA3531848_05737.
DR   GeneID; 42612311; -.
DR   GeneID; 58391949; -.
DR   PATRIC; fig|573.1352.peg.5296; -.
DR   Proteomes; UP000218240; Unassembled WGS sequence.
DR   Proteomes; UP000236255; Plasmid pkpc-224e.
DR   Proteomes; UP000464568; Plasmid pk18an, strain k18an.
DR   Proteomes; UP000464832; Plasmid pK45-67VIM.
DR   Proteomes; UP000515327; Plasmid pWP4-S18-CRE-04_3.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000150; F:recombinase activity; IEA:InterPro.
DR   GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1390; -; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR006118; Recombinase_CS.
DR   InterPro; IPR006119; Resolv_N.
DR   InterPro; IPR036162; Resolvase-like_N_sf.
DR   InterPro; IPR006120; Resolvase_HTH_dom.
DR   Pfam; PF02796; HTH_7; 1.
DR   Pfam; PF00239; Resolvase; 1.
DR   SMART; SM00857; Resolvase; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF53041; SSF53041; 1.
DR   PROSITE; PS00398; RECOMBINASES_2; 1.
DR   PROSITE; PS51736; RECOMBINASES_3; 1.
PE   3: Inferred from homology;
KW   DNA integration {ECO:0000256|ARBA:ARBA00022908};
KW   DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Plasmid {ECO:0000313|EMBL:ABY74391.1}.
FT   DOMAIN          1..140
FT                   /note="Resolvase/invertase-type recombinase catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS51736"
FT   ACT_SITE        9
FT                   /note="O-(5'-phospho-DNA)-serine intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR606118-50"
SQ   SEQUENCE   189 AA;  21131 MW;  5388132D1ABF5A5A CRC64;
     MKIGYARKST HLQDVAHQVD ELTKAGCEQI YQDQTSRSGP KRDKKGAPEL ENCLKALREG
     DTLVVWALDR LGGSLGQVIT LLDDLKKRGI TFIAIKDRID TNAPVIGEIY THLMAIFSSF
     ERNRNIERTR SGLAAARARG RVGGRKPSLS EEDVKQIRIL LADPEMTVGA VAKRFNVSRM
     TIYRYTTKS
//