ID B6RFL1_KLEPN Unreviewed; 189 AA. AC B6RFL1; DT 16-DEC-2008, integrated into UniProtKB/TrEMBL. DT 16-DEC-2008, sequence version 1. DT 07-OCT-2020, entry version 87. DE SubName: Full=Conserved domain protein {ECO:0000313|EMBL:ACI63186.1}; DE SubName: Full=MPF resolvase Uvp1 for plasmid R46 {ECO:0000313|EMBL:CDF32047.1}; DE SubName: Full=Recombinase family protein {ECO:0000313|EMBL:AUU98573.1}; DE SubName: Full=Resolvase {ECO:0000313|EMBL:ABY74391.1}; DE SubName: Full=Resolvase Uvp1 {ECO:0000313|EMBL:AFZ77109.1}; DE SubName: Full=Resolvase-like protein {ECO:0000313|EMBL:SBY90392.1}; DE SubName: Full=Site specific recombinase, DNA invertase {ECO:0000313|EMBL:AKS10512.1}; GN Name=resP {ECO:0000313|EMBL:ABY74391.1}; GN Synonyms=hin_3 {ECO:0000313|EMBL:SBY90392.1}, hin_4 GN {ECO:0000313|EMBL:VGH85419.1}, uvp-1 {ECO:0000313|EMBL:BAN17418.1}, GN uvp1 {ECO:0000313|EMBL:AIW55697.1}; GN ORFNames=BVX91_28505 {ECO:0000313|EMBL:PAX10020.1}, C2U49_28070 GN {ECO:0000313|EMBL:AUU98573.1}, C2U49_29380 GN {ECO:0000313|EMBL:AUU98789.1}, SAMEA3531848_05737 GN {ECO:0000313|EMBL:SBY90392.1}, SAMEA4873570_05056 GN {ECO:0000313|EMBL:VGH85419.1}; OS Klebsiella pneumoniae. OG Plasmid 12 {ECO:0000313|EMBL:ACI62990.1}, OG Plasmid 9 {ECO:0000313|EMBL:ACI63186.1}, OG Plasmid p12247J {ECO:0000313|EMBL:AJR19483.1}, OG Plasmid pBK31551 {ECO:0000313|EMBL:AFZ77109.1}, OG Plasmid pIMP-1495 {ECO:0000313|EMBL:AIW55697.1}, OG Plasmid pK18An {ECO:0000313|EMBL:CCN80147.1}, OG Plasmid pK45-67VIM {ECO:0000313|EMBL:CDF32047.1}, OG Plasmid pKP96 {ECO:0000313|EMBL:ABY74391.1}, OG Plasmid pKPC-224e {ECO:0000313|EMBL:AUU98573.1}, OG Plasmid pKPC-DK05 {ECO:0000313|EMBL:AKS10512.1}, OG Plasmid pKPI-6 {ECO:0000313|EMBL:BAM28997.1}, OG Plasmid pKPN-9729 {ECO:0000313|EMBL:AUU98789.1}, OG Plasmid pMTY14343_IncN {ECO:0000313|EMBL:BBD75787.1}, OG Plasmid pNDM-1saitama01 {ECO:0000313|EMBL:BAN17418.1}, OG Plasmid pNL194 {ECO:0000313|EMBL:ADG84865.1}, OG Plasmid pk18an {ECO:0000313|Proteomes:UP000464568}, OG Plasmid pk45-67vim complete sequence {ECO:0000313|Proteomes:UP000464832}, OG Plasmid pkpc-224e {ECO:0000313|Proteomes:UP000236255}, and OG Plasmid pkpn-9729 {ECO:0000313|Proteomes:UP000236255}. OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Klebsiella. OX NCBI_TaxID=573 {ECO:0000313|EMBL:ABY74391.1}; RN [1] {ECO:0000313|EMBL:ABY74391.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=KP96 {ECO:0000313|EMBL:ABY74391.1}; RC PLASMID=pKP96 {ECO:0000313|EMBL:ABY74391.1}; RX PubMed=18812424; DOI=10.1093/jac/dkn397; RA Shen P., Jiang Y., Zhou Z., Zhang J., Yu Y., Li L.; RT "Complete nucleotide sequence of pKP96, a 67 850 bp multiresistance plasmid RT encoding qnrA1, aac(6')-Ib-cr and blaCTX-M-24 from Klebsiella pneumoniae."; RL J. Antimicrob. Chemother. 62:1252-1256(2008). RN [2] {ECO:0000313|EMBL:ACI62990.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=12 {ECO:0000313|EMBL:ACI62990.1}, and 9 RC {ECO:0000313|EMBL:ACI63186.1}; RC PLASMID=12 {ECO:0000313|EMBL:ACI62990.1}, and 9 RC {ECO:0000313|EMBL:ACI63186.1}; RX PubMed=19258268; DOI=10.1128/AAC.01355-08; RA Gootz T.D., Lescoe M.K., Dib-Hajj F., Dougherty B.A., He W., RA Della-Latta P., Huard R.C.; RT "Genetic organization of transposase regions surrounding blaKPC RT carbapenemase genes on plasmids from Klebsiella strains isolated in a New RT York City hospital."; RL Antimicrob. Agents Chemother. 53:1998-2004(2009). RN [3] {ECO:0000313|EMBL:ADG84865.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=NL194 {ECO:0000313|EMBL:ADG84865.1}; RC PLASMID=pNL194 {ECO:0000313|EMBL:ADG84865.1}; RX PubMed=20660690; DOI=10.1128/AAC.00665-10; RA Miriagou V., Papagiannitsis C.C., Kotsakis S.D., Loli A., Tzelepi E., RA Legakis N.J., Tzouvelekis L.S.; RT "Sequence of pNL194, a 79.3-Kilobase IncN Plasmid Carrying the blaVIM-1 RT Metallo-{beta}-Lactamase Gene in Klebsiella pneumoniae."; RL Antimicrob. Agents Chemother. 54:4497-4502(2010). RN [4] {ECO:0000313|EMBL:BAM28997.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=A26 {ECO:0000313|EMBL:BAM28997.1}; RC PLASMID=pKPI-6 {ECO:0000313|EMBL:BAM28997.1}; RX PubMed=22078906; DOI=10.1016/j.diagmicrobio.2011.09.019; RA Shigemoto N., Kuwahara R., Kayama S., Shimizu W., Onodera M., Yokozaki M., RA Hisatsune J., Kato F., Ohge H., Sugai M.; RT "Emergence in Japan of an imipenem-susceptible, meropenem-resistant RT Klebsiella pneumoniae carrying blaIMP-6."; RL Diagn. Microbiol. Infect. Dis. 72:109-112(2012). RN [5] {ECO:0000313|EMBL:CCN80147.1, ECO:0000313|Proteomes:UP000464568} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K18An {ECO:0000313|EMBL:CCN80147.1, RC ECO:0000313|Proteomes:UP000464568}; RC PLASMID=pK18An {ECO:0000313|EMBL:CCN80147.1}, and pk18an, strain k18an RC {ECO:0000313|Proteomes:UP000464568}; RA Le V.; RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000313|EMBL:AFZ77109.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BK31551 {ECO:0000313|EMBL:AFZ77109.1}; RC PLASMID=pBK31551 {ECO:0000313|EMBL:AFZ77109.1}; RX PubMed=23114770; DOI=10.1128/AAC.01648-12; RA Chen L., Chavda K.D., Fraimow H.S., Mediavilla J.R., Melano R.G., RA Jacobs M.R., Bonomo R.A., Kreiswirth B.N.; RT "Complete Nucleotide Sequences of blaKPC-4- and blaKPC-5-Harboring IncN and RT IncX Plasmids from Klebsiella pneumoniae Strains Isolated in New Jersey."; RL Antimicrob. Agents Chemother. 57:269-276(2013). RN [7] {ECO:0000313|EMBL:BAN17418.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=NDM-1saitama01 {ECO:0000313|EMBL:BAN17418.1}; RC PLASMID=pNDM-1saitama01 {ECO:0000313|EMBL:BAN17418.1}; RX PubMed=23681270; DOI=10.1093/jac/dkt190; RA Hishinuma A., Yoshida A., Suzuki H., Okuzumi K., Ishida T.; RT "Complete sequencing of an IncFII NDM-1 plasmid in Klebsiella pneumoniae RT shows structural features shared with other multidrug resistance RT plasmids."; RL J. Antimicrob. Chemother. 68:2415-2417(2013). RN [8] {ECO:0000313|EMBL:CCN80147.1, ECO:0000313|Proteomes:UP000464568} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K18An {ECO:0000313|EMBL:CCN80147.1, RC ECO:0000313|Proteomes:UP000464568}; RC PLASMID=pK18An {ECO:0000313|EMBL:CCN80147.1}, and pk18an, strain k18an RC {ECO:0000313|Proteomes:UP000464568}; RA Le T.M.V., Nguyen T.K.N., Campbell J.I., Schultsz C., Cerdeno-Tarraga A.M., RA Thomson N.R., Farrar J.J., Baker S.; RT "Annotation of 3 multi-drug resistance qnrS1 harbouring plasmids and a RT widespread of qnrS1-containing transposons circulating in RT Enterobacteriaceae in Ho Chi Minh City, Vietnam."; RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:CDF32047.1, ECO:0000313|Proteomes:UP000464832} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K45-67 {ECO:0000313|EMBL:CDF32047.1, RC ECO:0000313|Proteomes:UP000464832}; RC PLASMID=pK45-67VIM {ECO:0000313|EMBL:CDF32047.1}, and pk45-67vim RC complete sequence {ECO:0000313|Proteomes:UP000464832}; RA Naseer U.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [10] {ECO:0000313|EMBL:CDF32047.1, ECO:0000313|Proteomes:UP000464832} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K45-67 {ECO:0000313|EMBL:CDF32047.1, RC ECO:0000313|Proteomes:UP000464832}; RC PLASMID=pK45-67VIM {ECO:0000313|EMBL:CDF32047.1}, and pk45-67vim RC complete sequence {ECO:0000313|Proteomes:UP000464832}; RA Cantas L.C., Samuelsen O.S., Naseer U.N., Sundsfjord A.S., Sorum H.S.; RT "Impact of the host and medical treatment on the transfer of a blaVIM-1 RT IncN plasmid in an in vivo zebrafish gut model."; RL Submitted (JUN-2013) to the EMBL/GenBank/DDBJ databases. RN [11] {ECO:0000313|EMBL:AJR19483.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=27243D {ECO:0000313|EMBL:AJR19483.1}; RC PLASMID=p12247J {ECO:0000313|EMBL:AJR19483.1}; RA Farrell S.E., Mendes R.E., Jones R.N.; RT "Characterization of plasmid mediated KPC-2 and IMP-4 carbapenemases in a RT Klebsiella pneumonia isolate from China."; RL Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases. RN [12] {ECO:0000313|EMBL:AIW55697.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=CRE1495 {ECO:0000313|EMBL:AIW55697.1}; RC PLASMID=pIMP-1495 {ECO:0000313|EMBL:AIW55697.1}; RA Ho P.L., Wang Y., Lo W.U., Law P.Y.T., Liu C.J., Chow K.H., Lai E.L.; RT "Complete Sequence of an IncN Plasmid, pIMP-1495, Carrying blaIMP-4 in a RT Klebsiella pneumoniae Strain."; RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases. RN [13] {ECO:0000313|EMBL:AKS10512.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=KPC-DK05 {ECO:0000313|EMBL:AKS10512.1}; RC PLASMID=pKPC-DK05 {ECO:0000313|EMBL:AKS10512.1}; RA Kim S.Y.; RT "Complete sequence of a blaKPC-2-harbouring IncN2-type plasmid from RT Klebsiella pneumoniae in Korea."; RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases. RN [14] {ECO:0000313|EMBL:SBY90392.1, ECO:0000313|Proteomes:UP000092856} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=5012STDY7626369 {ECO:0000313|EMBL:VGH85419.1, RC ECO:0000313|Proteomes:UP000343310}, and PB463 RC {ECO:0000313|EMBL:SBY90392.1, ECO:0000313|Proteomes:UP000092856}; RG Pathogen Informatics; RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases. RN [15] {ECO:0000313|EMBL:PAX10020.1, ECO:0000313|Proteomes:UP000218240} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=WBB417 {ECO:0000313|EMBL:PAX10020.1, RC ECO:0000313|Proteomes:UP000218240}; RA Koh T.H., Abdul Rahman N., Teo J.W., La M.-V., Periaswamy B., Chen S.L.; RT "Draft Genome Sequence of a Singapore Klebsiella pneumoniae subsp. RT pnuemoniae isolate DS32358_14 Encoding the Carbapenemase Gene blaVIM-1."; RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases. RN [16] {ECO:0000313|Proteomes:UP000236255} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KPNIH49 {ECO:0000313|Proteomes:UP000236255}; RC PLASMID=pkpc-224e {ECO:0000313|Proteomes:UP000236255}, and pkpn-9729 RC {ECO:0000313|Proteomes:UP000236255}; RX PubMed=29437920; RG NISC Comparative Sequencing Program; RA Weingarten R.A., Johnson R.C., Conlan S., Ramsburg A.M., Dekker J.P., RA Lau A.F., Khil P., Odom R.T., Deming C., Park M., Thomas P.J., RA Henderson D.K., Palmore T.N., Segre J.A., Frank K.M.; RT "Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of RT Bacterial Plasmids Conferring Carbapenem Resistance."; RL MBio 9:e02011-17(2018). RN [17] {ECO:0000313|EMBL:AUU98573.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=KPNIH49 {ECO:0000313|EMBL:AUU98573.1}; RC PLASMID=pKPC-224e {ECO:0000313|EMBL:AUU98573.1}, and pKPN-9729 RC {ECO:0000313|EMBL:AUU98789.1}; RG NISC Comparative Sequencing Program; RA Weingarten R.A., Johnson R.C., Conlan S., Ramsburg A.M., Dekker J.P., RA Lau A.F., Khil P., Odom R.T., Deming C., Park M., Thomas P.J., RA Henderson D.K., Palmore T.N., Segre J.A., Frank K.M.; RT "Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of RT Bacterial Plasmids Conferring Carbapenem Resistance."; RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases. RN [18] {ECO:0000313|EMBL:AUU98573.1, ECO:0000313|Proteomes:UP000236255} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KPNIH49 {ECO:0000313|EMBL:AUU98573.1, RC ECO:0000313|Proteomes:UP000236255}; RC PLASMID=pkpc-224e {ECO:0000313|Proteomes:UP000236255}, pKPC-224e RC {ECO:0000313|EMBL:AUU98573.1}, pKPN-9729 RC {ECO:0000313|EMBL:AUU98789.1}, and pkpn-9729 RC {ECO:0000313|Proteomes:UP000236255}; RA Segre J.A., Mullikin J.; RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases. RN [19] {ECO:0000313|EMBL:BBD75787.1, ECO:0000313|Proteomes:UP000289874} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=TUM14373 {ECO:0000313|EMBL:BBD75787.1, RC ECO:0000313|Proteomes:UP000289874}; RC PLASMID=Chromosome {ECO:0000313|Proteomes:UP000289874}, and RC pMTY14343_IncN {ECO:0000313|EMBL:BBD75787.1}; RA Ito K., Honda H., Yoshida M., Aoki K., Ishii Y., Miyokawa S., Horikoshi Y.; RT "A metallo-beta-lactamase-producing enterobacteriaceae outbreak due to a RT contaminated cold tea dispenser at a children's hospital."; RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the site-specific recombinase resolvase family. CC {ECO:0000256|ARBA:ARBA00009913}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; EU195449; ABY74391.1; -; Genomic_DNA. DR EMBL; FJ223605; ACI62990.1; -; Genomic_DNA. DR EMBL; FJ223607; ACI63186.1; -; Genomic_DNA. DR EMBL; GU585907; ADG84865.1; -; Genomic_DNA. DR EMBL; JX193301; AFZ77109.1; -; Genomic_DNA. DR EMBL; KM977631; AIW55697.1; -; Genomic_DNA. DR EMBL; KF680003; AJR19483.1; -; Genomic_DNA. DR EMBL; KR091915; AKS10512.1; -; Genomic_DNA. DR EMBL; CP026179; AUU98573.1; -; Genomic_DNA. DR EMBL; CP026180; AUU98789.1; -; Genomic_DNA. DR EMBL; AB616660; BAM28997.1; -; Genomic_DNA. DR EMBL; AB759690; BAN17418.1; -; Genomic_DNA. DR EMBL; AP018557; BBD75787.1; -; Genomic_DNA. DR EMBL; HF545435; CCN80147.1; -; Genomic_DNA. DR EMBL; HF955507; CDF32047.1; -; Genomic_DNA. DR EMBL; NSMB01000092; PAX10020.1; -; Genomic_DNA. DR EMBL; FLXG01000060; SBY90392.1; -; Genomic_DNA. DR EMBL; CAAGZQ010000029; VGH85419.1; -; Genomic_DNA. DR RefSeq; WP_001749988.1; NZ_WXZN01000026.1. DR RefSeq; YP_002286838.1; NC_011383.1. DR RefSeq; YP_002286932.1; NC_011385.1. DR RefSeq; YP_002332849.1; NC_011617.1. DR RefSeq; YP_003813096.1; NC_014368.1. DR RefSeq; YP_007195370.1; NC_019888.1. DR RefSeq; YP_007349714.1; NC_020088.1. DR RefSeq; YP_007936884.1; NC_021180.1. DR RefSeq; YP_008145015.1; NC_021622.1. DR EnsemblBacteria; SBY90392; SBY90392; SAMEA3531848_05737. DR GeneID; 14411236; -. DR GeneID; 15230208; -. DR GeneID; 15414750; -. DR GeneID; 16185048; -. DR GeneID; 42612311; -. DR GeneID; 6993946; -. DR GeneID; 6993953; -. DR GeneID; 7065626; -. DR GeneID; 9499772; -. DR KEGG; kpb:FH42_26845; -. DR PATRIC; fig|573.1352.peg.5296; -. DR Proteomes; UP000092856; Unassembled WGS sequence. DR Proteomes; UP000218240; Unassembled WGS sequence. DR Proteomes; UP000236255; Plasmid pkpn-9729. DR Proteomes; UP000289874; Chromosome. DR Proteomes; UP000343310; Unassembled WGS sequence. DR Proteomes; UP000464568; Plasmid pk18an, strain k18an. DR Proteomes; UP000464832; Plasmid pk45-67vim complete sequence. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0000150; F:recombinase activity; IEA:InterPro. DR GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW. DR Gene3D; 3.40.50.1390; -; 1. DR InterPro; IPR009057; Homeobox-like_sf. DR InterPro; IPR006118; Recombinase_CS. DR InterPro; IPR006119; Resolv_N. DR InterPro; IPR036162; Resolvase-like_N_sf. DR InterPro; IPR006120; Resolvase_HTH_dom. DR Pfam; PF02796; HTH_7; 1. DR Pfam; PF00239; Resolvase; 1. DR SMART; SM00857; Resolvase; 1. DR SUPFAM; SSF46689; SSF46689; 1. DR SUPFAM; SSF53041; SSF53041; 1. DR PROSITE; PS00398; RECOMBINASES_2; 1. DR PROSITE; PS51736; RECOMBINASES_3; 1. PE 3: Inferred from homology; KW DNA integration {ECO:0000256|ARBA:ARBA00022908}; KW DNA recombination {ECO:0000256|ARBA:ARBA00023172}; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125}; KW Plasmid {ECO:0000313|EMBL:ABY74391.1}. FT DOMAIN 1..140 FT /note="Resolvase/invertase-type recombinase catalytic" FT /evidence="ECO:0000259|PROSITE:PS51736" FT ACT_SITE 9 FT /note="O-(5'-phospho-DNA)-serine intermediate" FT /evidence="ECO:0000256|PIRSR:PIRSR606118-50" SQ SEQUENCE 189 AA; 21131 MW; 5388132D1ABF5A5A CRC64; MKIGYARKST HLQDVAHQVD ELTKAGCEQI YQDQTSRSGP KRDKKGAPEL ENCLKALREG DTLVVWALDR LGGSLGQVIT LLDDLKKRGI TFIAIKDRID TNAPVIGEIY THLMAIFSSF ERNRNIERTR SGLAAARARG RVGGRKPSLS EEDVKQIRIL LADPEMTVGA VAKRFNVSRM TIYRYTTKS //