ID   B6RFL1_KLEPN            Unreviewed;       189 AA.
AC   B6RFL1;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 1.
DT   24-JAN-2024, entry version 101.
DE   SubName: Full=Conserved domain protein {ECO:0000313|EMBL:ACI63186.1};
DE   SubName: Full=Resolvase {ECO:0000313|EMBL:ABY74391.1, ECO:0000313|EMBL:CDF32047.1};
DE   SubName: Full=Recombinase family protein {ECO:0000313|EMBL:QJL32362.1};
DE   SubName: Full=Resolvase Uvp1 {ECO:0000313|EMBL:AFZ77109.1};
DE   SubName: Full=Resolvase-like protein {ECO:0000313|EMBL:SWU64761.1};
DE   SubName: Full=Site specific recombinase, DNA invertase {ECO:0000313|EMBL:AKS10512.1};
GN   Name=resP {ECO:0000313|EMBL:ABY74391.1};
GN   Synonyms=hin_2 {ECO:0000313|EMBL:SWU64761.1}, hin_3
GN   {ECO:0000313|EMBL:SXG19411.1}, uvp-1 {ECO:0000313|EMBL:BAN17418.1},
GN   uvp1 {ECO:0000313|EMBL:AIW55697.1};
GN   ORFNames=B6I55_00175 {ECO:0000313|EMBL:PLD48882.1}, GJJ08_027300
GN   {ECO:0000313|EMBL:QOU54602.1}, HJX03_28095
GN   {ECO:0000313|EMBL:QJL32362.1}, SAMEA3499874_05327
GN   {ECO:0000313|EMBL:SXG19411.1}, SAMEA3538828_05286
GN   {ECO:0000313|EMBL:SYR48804.1}, SAMEA3727701_05521
GN   {ECO:0000313|EMBL:SWU64761.1}, SAMEA4873597_05383
GN   {ECO:0000313|EMBL:VGJ61364.1};
OS   Klebsiella pneumoniae.
OG   Plasmid 12 {ECO:0000313|EMBL:ACI62990.1},
OG   Plasmid 9 {ECO:0000313|EMBL:ACI63186.1},
OG   Plasmid p12247J {ECO:0000313|EMBL:AJR19483.1},
OG   Plasmid pBK31551 {ECO:0000313|EMBL:AFZ77109.1},
OG   Plasmid pC16KP0122-2 {ECO:0000313|EMBL:QJL32362.1},
OG   Plasmid pIMP-1495 {ECO:0000313|EMBL:AIW55697.1},
OG   Plasmid pK18An {ECO:0000313|EMBL:CCN80147.1},
OG   Plasmid pK45-67VIM {ECO:0000313|EMBL:CDF32047.1},
OG   Plasmid pKP96 {ECO:0000313|EMBL:ABY74391.1},
OG   Plasmid pKPC-DK05 {ECO:0000313|EMBL:AKS10512.1},
OG   Plasmid pKPI-6 {ECO:0000313|EMBL:BAM28997.1},
OG   Plasmid pNDM-1saitama01 {ECO:0000313|EMBL:BAN17418.1},
OG   Plasmid pNL194 {ECO:0000313|EMBL:ADG84865.1},
OG   Plasmid pc16kp0122-2 {ECO:0000313|Proteomes:UP000503203}, and
OG   Plasmid unnamed1 {ECO:0000313|EMBL:QOU54602.1,
OG   ECO:0000313|Proteomes:UP000439817}.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=573 {ECO:0000313|EMBL:ABY74391.1};
RN   [1] {ECO:0000313|EMBL:ABY74391.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=KP96 {ECO:0000313|EMBL:ABY74391.1};
RC   PLASMID=pKP96 {ECO:0000313|EMBL:ABY74391.1};
RX   PubMed=18812424; DOI=10.1093/jac/dkn397;
RA   Shen P., Jiang Y., Zhou Z., Zhang J., Yu Y., Li L.;
RT   "Complete nucleotide sequence of pKP96, a 67 850 bp multiresistance plasmid
RT   encoding qnrA1, aac(6')-Ib-cr and blaCTX-M-24 from Klebsiella pneumoniae.";
RL   J. Antimicrob. Chemother. 62:1252-1256(2008).
RN   [2] {ECO:0000313|EMBL:ACI62990.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=12 {ECO:0000313|EMBL:ACI62990.1}, and 9
RC   {ECO:0000313|EMBL:ACI63186.1};
RC   PLASMID=12 {ECO:0000313|EMBL:ACI62990.1}, and 9
RC   {ECO:0000313|EMBL:ACI63186.1};
RX   PubMed=19258268; DOI=10.1128/AAC.01355-08;
RA   Gootz T.D., Lescoe M.K., Dib-Hajj F., Dougherty B.A., He W.,
RA   Della-Latta P., Huard R.C.;
RT   "Genetic organization of transposase regions surrounding blaKPC
RT   carbapenemase genes on plasmids from Klebsiella strains isolated in a New
RT   York City hospital.";
RL   Antimicrob. Agents Chemother. 53:1998-2004(2009).
RN   [3] {ECO:0000313|EMBL:ADG84865.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NL194 {ECO:0000313|EMBL:ADG84865.1};
RC   PLASMID=pNL194 {ECO:0000313|EMBL:ADG84865.1};
RX   PubMed=20660690; DOI=10.1128/AAC.00665-10;
RA   Miriagou V., Papagiannitsis C.C., Kotsakis S.D., Loli A., Tzelepi E.,
RA   Legakis N.J., Tzouvelekis L.S.;
RT   "Sequence of pNL194, a 79.3-Kilobase IncN Plasmid Carrying the blaVIM-1
RT   Metallo-{beta}-Lactamase Gene in Klebsiella pneumoniae.";
RL   Antimicrob. Agents Chemother. 54:4497-4502(2010).
RN   [4] {ECO:0000313|EMBL:BAM28997.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=A26 {ECO:0000313|EMBL:BAM28997.1};
RC   PLASMID=pKPI-6 {ECO:0000313|EMBL:BAM28997.1};
RX   PubMed=22078906; DOI=10.1016/j.diagmicrobio.2011.09.019;
RA   Shigemoto N., Kuwahara R., Kayama S., Shimizu W., Onodera M., Yokozaki M.,
RA   Hisatsune J., Kato F., Ohge H., Sugai M.;
RT   "Emergence in Japan of an imipenem-susceptible, meropenem-resistant
RT   Klebsiella pneumoniae carrying blaIMP-6.";
RL   Diagn. Microbiol. Infect. Dis. 72:109-112(2012).
RN   [5] {ECO:0000313|EMBL:CCN80147.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K18An {ECO:0000313|EMBL:CCN80147.1};
RC   PLASMID=pK18An {ECO:0000313|EMBL:CCN80147.1};
RA   Le V.;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:AFZ77109.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BK31551 {ECO:0000313|EMBL:AFZ77109.1};
RC   PLASMID=pBK31551 {ECO:0000313|EMBL:AFZ77109.1};
RX   PubMed=23114770; DOI=10.1128/AAC.01648-12;
RA   Chen L., Chavda K.D., Fraimow H.S., Mediavilla J.R., Melano R.G.,
RA   Jacobs M.R., Bonomo R.A., Kreiswirth B.N.;
RT   "Complete Nucleotide Sequences of blaKPC-4- and blaKPC-5-Harboring IncN and
RT   IncX Plasmids from Klebsiella pneumoniae Strains Isolated in New Jersey.";
RL   Antimicrob. Agents Chemother. 57:269-276(2013).
RN   [7] {ECO:0000313|EMBL:BAN17418.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NDM-1saitama01 {ECO:0000313|EMBL:BAN17418.1};
RC   PLASMID=pNDM-1saitama01 {ECO:0000313|EMBL:BAN17418.1};
RX   PubMed=23681270; DOI=10.1093/jac/dkt190;
RA   Hishinuma A., Yoshida A., Suzuki H., Okuzumi K., Ishida T.;
RT   "Complete sequencing of an IncFII NDM-1 plasmid in Klebsiella pneumoniae
RT   shows structural features shared with other multidrug resistance
RT   plasmids.";
RL   J. Antimicrob. Chemother. 68:2415-2417(2013).
RN   [8] {ECO:0000313|EMBL:CCN80147.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K18An {ECO:0000313|EMBL:CCN80147.1};
RC   PLASMID=pK18An {ECO:0000313|EMBL:CCN80147.1};
RA   Le T.M.V., Nguyen T.K.N., Campbell J.I., Schultsz C., Cerdeno-Tarraga A.M.,
RA   Thomson N.R., Farrar J.J., Baker S.;
RT   "Annotation of 3 multi-drug resistance qnrS1 harbouring plasmids and a
RT   widespread of qnrS1-containing transposons circulating in
RT   Enterobacteriaceae in Ho Chi Minh City, Vietnam.";
RL   Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
RN   [9] {ECO:0000313|EMBL:CDF32047.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K45-67 {ECO:0000313|EMBL:CDF32047.1};
RC   PLASMID=pK45-67VIM {ECO:0000313|EMBL:CDF32047.1};
RA   Naseer U.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [10] {ECO:0000313|EMBL:CDF32047.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K45-67 {ECO:0000313|EMBL:CDF32047.1};
RC   PLASMID=pK45-67VIM {ECO:0000313|EMBL:CDF32047.1};
RA   Cantas L.C., Samuelsen O.S., Naseer U.N., Sundsfjord A.S., Sorum H.S.;
RT   "Impact of the host and medical treatment on the transfer of a blaVIM-1
RT   IncN plasmid in an in vivo zebrafish gut model.";
RL   Submitted (JUN-2013) to the EMBL/GenBank/DDBJ databases.
RN   [11] {ECO:0000313|EMBL:AJR19483.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=27243D {ECO:0000313|EMBL:AJR19483.1};
RC   PLASMID=p12247J {ECO:0000313|EMBL:AJR19483.1};
RA   Farrell S.E., Mendes R.E., Jones R.N.;
RT   "Characterization of plasmid mediated KPC-2 and IMP-4 carbapenemases in a
RT   Klebsiella pneumonia isolate from China.";
RL   Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
RN   [12] {ECO:0000313|EMBL:AIW55697.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CRE1495 {ECO:0000313|EMBL:AIW55697.1};
RC   PLASMID=pIMP-1495 {ECO:0000313|EMBL:AIW55697.1};
RA   Ho P.L., Wang Y., Lo W.U., Law P.Y.T., Liu C.J., Chow K.H., Lai E.L.;
RT   "Complete Sequence of an IncN Plasmid, pIMP-1495, Carrying blaIMP-4 in a
RT   Klebsiella pneumoniae Strain.";
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
RN   [13] {ECO:0000313|EMBL:AKS10512.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=KPC-DK05 {ECO:0000313|EMBL:AKS10512.1};
RC   PLASMID=pKPC-DK05 {ECO:0000313|EMBL:AKS10512.1};
RA   Kim S.Y.;
RT   "Complete sequence of a blaKPC-2-harbouring IncN2-type plasmid from
RT   Klebsiella pneumoniae in Korea.";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN   [14] {ECO:0000313|EMBL:PLD48882.1, ECO:0000313|Proteomes:UP000234595}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=COL-Kpn17 {ECO:0000313|EMBL:PLD48882.1,
RC   ECO:0000313|Proteomes:UP000234595};
RX   PubMed=29029188; DOI=.1093/infdis/jix524;
RA   Rojas L.J., Weinstock G.M., De La Cadena E., Diaz L., Rios R., Hanson B.M.,
RA   Brown J.S., Vats P., Phillips D.S., Nguyen H., Hujer K.M., Correa A.,
RA   Adams M.D., Perez F., Sodergren E., Narechania A., Planet P.J.,
RA   Villegas M.V., Bonomo R.A., Arias C.A.;
RT   "An Analysis of the Epidemic of Klebsiella pneumoniae Carbapenemase-
RT   Producing K. pneumoniae: Convergence of Two Evolutionary Mechanisms Creates
RT   the "Perfect Storm".";
RL   J. Infect. Dis. 217:82-92(2017).
RN   [15] {ECO:0000313|Proteomes:UP000257410, ECO:0000313|Proteomes:UP000257587}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=5012STDY7626396 {ECO:0000313|EMBL:VGJ61364.1,
RC   ECO:0000313|Proteomes:UP000295133}, EuSCAPE_AT002
RC   {ECO:0000313|EMBL:SXG19411.1, ECO:0000313|Proteomes:UP000257587},
RC   EuSCAPE_BE105 {ECO:0000313|EMBL:SWU64761.1,
RC   ECO:0000313|Proteomes:UP000257410}, and EuSCAPE_HU047
RC   {ECO:0000313|EMBL:SYR48804.1, ECO:0000313|Proteomes:UP000258253};
RG   Pathogen Informatics;
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
RN   [16] {ECO:0000313|EMBL:QOU54602.1, ECO:0000313|Proteomes:UP000439817}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CriePir120 {ECO:0000313|EMBL:QOU54602.1,
RC   ECO:0000313|Proteomes:UP000439817};
RC   PLASMID=unnamed1 {ECO:0000313|EMBL:QOU54602.1,
RC   ECO:0000313|Proteomes:UP000439817};
RX   PubMed=32429555;
RA   Shelenkov A., Mikhaylova Y., Yanushevich Y., Samoilov A., Petrova L.,
RA   Fomina V., Gusarov V., Zamyatin M., Shagin D., Akimkin V.;
RT   "Molecular Typing, Characterization of Antimicrobial Resistance, Virulence
RT   Profiling and Analysis of Whole-Genome Sequence of Clinical Klebsiella
RT   pneumoniae Isolates.";
RL   Antibiotics 9:E261-E261(2020).
RN   [17] {ECO:0000313|EMBL:QJL32362.1, ECO:0000313|Proteomes:UP000503203}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C16KP0122 {ECO:0000313|EMBL:QJL32362.1,
RC   ECO:0000313|Proteomes:UP000503203};
RC   PLASMID=pC16KP0122-2 {ECO:0000313|EMBL:QJL32362.1}, and pc16kp0122-2
RC   {ECO:0000313|Proteomes:UP000503203};
RA   Yoon E.-J., Gwon B., Liu C., Kim D., Won D., Park S.G., Choi J.R.,
RA   Jeong S.H.;
RT   "Built-in CTX-M extended-spectrum beta-lactamase gene in Klebsiella
RT   pneumoniae ensuring stable propagation of the multidrug-resistant pathogen
RT   in clinical settings.";
RL   Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the site-specific recombinase resolvase family.
CC       {ECO:0000256|ARBA:ARBA00009913}.
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DR   EMBL; EU195449; ABY74391.1; -; Genomic_DNA.
DR   EMBL; FJ223605; ACI62990.1; -; Genomic_DNA.
DR   EMBL; FJ223607; ACI63186.1; -; Genomic_DNA.
DR   EMBL; GU585907; ADG84865.1; -; Genomic_DNA.
DR   EMBL; JX193301; AFZ77109.1; -; Genomic_DNA.
DR   EMBL; KM977631; AIW55697.1; -; Genomic_DNA.
DR   EMBL; KF680003; AJR19483.1; -; Genomic_DNA.
DR   EMBL; KR091915; AKS10512.1; -; Genomic_DNA.
DR   EMBL; AB616660; BAM28997.1; -; Genomic_DNA.
DR   EMBL; AB759690; BAN17418.1; -; Genomic_DNA.
DR   EMBL; HF545435; CCN80147.1; -; Genomic_DNA.
DR   EMBL; HF955507; CDF32047.1; -; Genomic_DNA.
DR   EMBL; NCLW01000001; PLD48882.1; -; Genomic_DNA.
DR   EMBL; CP052433; QJL32362.1; -; Genomic_DNA.
DR   EMBL; CP063009; QOU54602.1; -; Genomic_DNA.
DR   EMBL; UJSE01000069; SWU64761.1; -; Genomic_DNA.
DR   EMBL; UKAW01000052; SXG19411.1; -; Genomic_DNA.
DR   EMBL; ULCI01000069; SYR48804.1; -; Genomic_DNA.
DR   EMBL; CAAHAW010000032; VGJ61364.1; -; Genomic_DNA.
DR   RefSeq; WP_001749988.1; NZ_WXZN01000026.1.
DR   RefSeq; YP_002286838.1; NC_011383.1.
DR   RefSeq; YP_002286932.1; NC_011385.1.
DR   RefSeq; YP_002332849.1; NC_011617.1.
DR   RefSeq; YP_003813096.1; NC_014368.1.
DR   RefSeq; YP_007195370.1; NC_019888.1.
DR   RefSeq; YP_007349714.1; NC_020088.1.
DR   RefSeq; YP_008145015.1; NC_021622.1.
DR   GeneID; 83649166; -.
DR   KEGG; kpb:FH42_26845; -.
DR   PATRIC; fig|573.1352.peg.5296; -.
DR   Proteomes; UP000234595; Unassembled WGS sequence.
DR   Proteomes; UP000257410; Unassembled WGS sequence.
DR   Proteomes; UP000257587; Unassembled WGS sequence.
DR   Proteomes; UP000258253; Unassembled WGS sequence.
DR   Proteomes; UP000295133; Unassembled WGS sequence.
DR   Proteomes; UP000439817; Plasmid unnamed1.
DR   Proteomes; UP000503203; Plasmid pc16kp0122-2.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000150; F:DNA strand exchange activity; IEA:InterPro.
DR   GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR   CDD; cd00569; HTH_Hin_like; 1.
DR   CDD; cd03768; SR_ResInv; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   Gene3D; 3.40.50.1390; Resolvase, N-terminal catalytic domain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR006118; Recombinase_CS.
DR   InterPro; IPR006119; Resolv_N.
DR   InterPro; IPR036162; Resolvase-like_N_sf.
DR   InterPro; IPR006120; Resolvase_HTH_dom.
DR   PANTHER; PTHR30461; DNA-INVERTASE FROM LAMBDOID PROPHAGE; 1.
DR   PANTHER; PTHR30461:SF22; SERINE RECOMBINASE PINE-RELATED; 1.
DR   Pfam; PF02796; HTH_7; 1.
DR   Pfam; PF00239; Resolvase; 1.
DR   SMART; SM00857; Resolvase; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   SUPFAM; SSF53041; Resolvase-like; 1.
DR   PROSITE; PS00398; RECOMBINASES_2; 1.
DR   PROSITE; PS51736; RECOMBINASES_3; 1.
PE   3: Inferred from homology;
KW   DNA integration {ECO:0000256|ARBA:ARBA00022908};
KW   DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Plasmid {ECO:0000313|EMBL:ABY74391.1}.
FT   DOMAIN          1..140
FT                   /note="Resolvase/invertase-type recombinase catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS51736"
FT   ACT_SITE        9
FT                   /note="O-(5'-phospho-DNA)-serine intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR606118-50"
SQ   SEQUENCE   189 AA;  21131 MW;  5388132D1ABF5A5A CRC64;
     MKIGYARKST HLQDVAHQVD ELTKAGCEQI YQDQTSRSGP KRDKKGAPEL ENCLKALREG
     DTLVVWALDR LGGSLGQVIT LLDDLKKRGI TFIAIKDRID TNAPVIGEIY THLMAIFSSF
     ERNRNIERTR SGLAAARARG RVGGRKPSLS EEDVKQIRIL LADPEMTVGA VAKRFNVSRM
     TIYRYTTKS
//