ID B6RFL1_KLEPN Unreviewed; 189 AA. AC B6RFL1; DT 16-DEC-2008, integrated into UniProtKB/TrEMBL. DT 16-DEC-2008, sequence version 1. DT 13-SEP-2023, entry version 100. DE SubName: Full=Conserved domain protein {ECO:0000313|EMBL:ACI63186.1}; DE SubName: Full=MPF resolvase Uvp1 for plasmid R46 {ECO:0000313|EMBL:CDF32047.1}; DE SubName: Full=Recombinase family protein {ECO:0000313|EMBL:QJL32362.1}; DE SubName: Full=Resolvase {ECO:0000313|EMBL:ABY74391.1}; DE SubName: Full=Resolvase Uvp1 {ECO:0000313|EMBL:AFZ77109.1}; DE SubName: Full=Resolvase-like protein {ECO:0000313|EMBL:SWU64761.1}; DE SubName: Full=Site specific recombinase, DNA invertase {ECO:0000313|EMBL:AKS10512.1}; GN Name=resP {ECO:0000313|EMBL:ABY74391.1}; GN Synonyms=hin_2 {ECO:0000313|EMBL:SWU64761.1}, hin_3 GN {ECO:0000313|EMBL:SXG19411.1}, uvp-1 {ECO:0000313|EMBL:BAN17418.1}, GN uvp1 {ECO:0000313|EMBL:AIW55697.1}; GN ORFNames=B6I55_00175 {ECO:0000313|EMBL:PLD48882.1}, GJJ08_027300 GN {ECO:0000313|EMBL:QOU54602.1}, HJX03_28095 GN {ECO:0000313|EMBL:QJL32362.1}, SAMEA3499874_05327 GN {ECO:0000313|EMBL:SXG19411.1}, SAMEA3538828_05286 GN {ECO:0000313|EMBL:SYR48804.1}, SAMEA3727701_05521 GN {ECO:0000313|EMBL:SWU64761.1}, SAMEA4873597_05383 GN {ECO:0000313|EMBL:VGJ61364.1}; OS Klebsiella pneumoniae. OG Plasmid 12 {ECO:0000313|EMBL:ACI62990.1}, OG Plasmid 9 {ECO:0000313|EMBL:ACI63186.1}, OG Plasmid p12247J {ECO:0000313|EMBL:AJR19483.1}, OG Plasmid pBK31551 {ECO:0000313|EMBL:AFZ77109.1}, OG Plasmid pC16KP0122-2 {ECO:0000313|EMBL:QJL32362.1}, OG Plasmid pIMP-1495 {ECO:0000313|EMBL:AIW55697.1}, OG Plasmid pK18An {ECO:0000313|EMBL:CCN80147.1}, OG Plasmid pK45-67VIM {ECO:0000313|EMBL:CDF32047.1}, OG Plasmid pKP96 {ECO:0000313|EMBL:ABY74391.1}, OG Plasmid pKPC-DK05 {ECO:0000313|EMBL:AKS10512.1}, OG Plasmid pKPI-6 {ECO:0000313|EMBL:BAM28997.1}, OG Plasmid pNDM-1saitama01 {ECO:0000313|EMBL:BAN17418.1}, OG Plasmid pNL194 {ECO:0000313|EMBL:ADG84865.1}, OG Plasmid pc16kp0122-2 {ECO:0000313|Proteomes:UP000503203}, and OG Plasmid unnamed1 {ECO:0000313|EMBL:QOU54602.1, OG ECO:0000313|Proteomes:UP000439817}. OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella. OX NCBI_TaxID=573 {ECO:0000313|EMBL:ABY74391.1}; RN [1] {ECO:0000313|EMBL:ABY74391.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=KP96 {ECO:0000313|EMBL:ABY74391.1}; RC PLASMID=pKP96 {ECO:0000313|EMBL:ABY74391.1}; RX PubMed=18812424; DOI=10.1093/jac/dkn397; RA Shen P., Jiang Y., Zhou Z., Zhang J., Yu Y., Li L.; RT "Complete nucleotide sequence of pKP96, a 67 850 bp multiresistance plasmid RT encoding qnrA1, aac(6')-Ib-cr and blaCTX-M-24 from Klebsiella pneumoniae."; RL J. Antimicrob. Chemother. 62:1252-1256(2008). RN [2] {ECO:0000313|EMBL:ACI62990.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=12 {ECO:0000313|EMBL:ACI62990.1}, and 9 RC {ECO:0000313|EMBL:ACI63186.1}; RC PLASMID=12 {ECO:0000313|EMBL:ACI62990.1}, and 9 RC {ECO:0000313|EMBL:ACI63186.1}; RX PubMed=19258268; DOI=10.1128/AAC.01355-08; RA Gootz T.D., Lescoe M.K., Dib-Hajj F., Dougherty B.A., He W., RA Della-Latta P., Huard R.C.; RT "Genetic organization of transposase regions surrounding blaKPC RT carbapenemase genes on plasmids from Klebsiella strains isolated in a New RT York City hospital."; RL Antimicrob. Agents Chemother. 53:1998-2004(2009). RN [3] {ECO:0000313|EMBL:ADG84865.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=NL194 {ECO:0000313|EMBL:ADG84865.1}; RC PLASMID=pNL194 {ECO:0000313|EMBL:ADG84865.1}; RX PubMed=20660690; DOI=10.1128/AAC.00665-10; RA Miriagou V., Papagiannitsis C.C., Kotsakis S.D., Loli A., Tzelepi E., RA Legakis N.J., Tzouvelekis L.S.; RT "Sequence of pNL194, a 79.3-Kilobase IncN Plasmid Carrying the blaVIM-1 RT Metallo-{beta}-Lactamase Gene in Klebsiella pneumoniae."; RL Antimicrob. Agents Chemother. 54:4497-4502(2010). RN [4] {ECO:0000313|EMBL:BAM28997.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=A26 {ECO:0000313|EMBL:BAM28997.1}; RC PLASMID=pKPI-6 {ECO:0000313|EMBL:BAM28997.1}; RX PubMed=22078906; DOI=10.1016/j.diagmicrobio.2011.09.019; RA Shigemoto N., Kuwahara R., Kayama S., Shimizu W., Onodera M., Yokozaki M., RA Hisatsune J., Kato F., Ohge H., Sugai M.; RT "Emergence in Japan of an imipenem-susceptible, meropenem-resistant RT Klebsiella pneumoniae carrying blaIMP-6."; RL Diagn. Microbiol. Infect. Dis. 72:109-112(2012). RN [5] {ECO:0000313|EMBL:CCN80147.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K18An {ECO:0000313|EMBL:CCN80147.1}; RC PLASMID=pK18An {ECO:0000313|EMBL:CCN80147.1}; RA Le V.; RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000313|EMBL:AFZ77109.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BK31551 {ECO:0000313|EMBL:AFZ77109.1}; RC PLASMID=pBK31551 {ECO:0000313|EMBL:AFZ77109.1}; RX PubMed=23114770; DOI=10.1128/AAC.01648-12; RA Chen L., Chavda K.D., Fraimow H.S., Mediavilla J.R., Melano R.G., RA Jacobs M.R., Bonomo R.A., Kreiswirth B.N.; RT "Complete Nucleotide Sequences of blaKPC-4- and blaKPC-5-Harboring IncN and RT IncX Plasmids from Klebsiella pneumoniae Strains Isolated in New Jersey."; RL Antimicrob. Agents Chemother. 57:269-276(2013). RN [7] {ECO:0000313|EMBL:BAN17418.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=NDM-1saitama01 {ECO:0000313|EMBL:BAN17418.1}; RC PLASMID=pNDM-1saitama01 {ECO:0000313|EMBL:BAN17418.1}; RX PubMed=23681270; DOI=10.1093/jac/dkt190; RA Hishinuma A., Yoshida A., Suzuki H., Okuzumi K., Ishida T.; RT "Complete sequencing of an IncFII NDM-1 plasmid in Klebsiella pneumoniae RT shows structural features shared with other multidrug resistance RT plasmids."; RL J. Antimicrob. Chemother. 68:2415-2417(2013). RN [8] {ECO:0000313|EMBL:CCN80147.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K18An {ECO:0000313|EMBL:CCN80147.1}; RC PLASMID=pK18An {ECO:0000313|EMBL:CCN80147.1}; RA Le T.M.V., Nguyen T.K.N., Campbell J.I., Schultsz C., Cerdeno-Tarraga A.M., RA Thomson N.R., Farrar J.J., Baker S.; RT "Annotation of 3 multi-drug resistance qnrS1 harbouring plasmids and a RT widespread of qnrS1-containing transposons circulating in RT Enterobacteriaceae in Ho Chi Minh City, Vietnam."; RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:CDF32047.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K45-67 {ECO:0000313|EMBL:CDF32047.1}; RC PLASMID=pK45-67VIM {ECO:0000313|EMBL:CDF32047.1}; RA Naseer U.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [10] {ECO:0000313|EMBL:CDF32047.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K45-67 {ECO:0000313|EMBL:CDF32047.1}; RC PLASMID=pK45-67VIM {ECO:0000313|EMBL:CDF32047.1}; RA Cantas L.C., Samuelsen O.S., Naseer U.N., Sundsfjord A.S., Sorum H.S.; RT "Impact of the host and medical treatment on the transfer of a blaVIM-1 RT IncN plasmid in an in vivo zebrafish gut model."; RL Submitted (JUN-2013) to the EMBL/GenBank/DDBJ databases. RN [11] {ECO:0000313|EMBL:AJR19483.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=27243D {ECO:0000313|EMBL:AJR19483.1}; RC PLASMID=p12247J {ECO:0000313|EMBL:AJR19483.1}; RA Farrell S.E., Mendes R.E., Jones R.N.; RT "Characterization of plasmid mediated KPC-2 and IMP-4 carbapenemases in a RT Klebsiella pneumonia isolate from China."; RL Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases. RN [12] {ECO:0000313|EMBL:AIW55697.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=CRE1495 {ECO:0000313|EMBL:AIW55697.1}; RC PLASMID=pIMP-1495 {ECO:0000313|EMBL:AIW55697.1}; RA Ho P.L., Wang Y., Lo W.U., Law P.Y.T., Liu C.J., Chow K.H., Lai E.L.; RT "Complete Sequence of an IncN Plasmid, pIMP-1495, Carrying blaIMP-4 in a RT Klebsiella pneumoniae Strain."; RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases. RN [13] {ECO:0000313|EMBL:AKS10512.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=KPC-DK05 {ECO:0000313|EMBL:AKS10512.1}; RC PLASMID=pKPC-DK05 {ECO:0000313|EMBL:AKS10512.1}; RA Kim S.Y.; RT "Complete sequence of a blaKPC-2-harbouring IncN2-type plasmid from RT Klebsiella pneumoniae in Korea."; RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases. RN [14] {ECO:0000313|EMBL:PLD48882.1, ECO:0000313|Proteomes:UP000234595} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=COL-Kpn17 {ECO:0000313|EMBL:PLD48882.1, RC ECO:0000313|Proteomes:UP000234595}; RX PubMed=29029188; DOI=.1093/infdis/jix524; RA Rojas L.J., Weinstock G.M., De La Cadena E., Diaz L., Rios R., Hanson B.M., RA Brown J.S., Vats P., Phillips D.S., Nguyen H., Hujer K.M., Correa A., RA Adams M.D., Perez F., Sodergren E., Narechania A., Planet P.J., RA Villegas M.V., Bonomo R.A., Arias C.A.; RT "An Analysis of the Epidemic of Klebsiella pneumoniae Carbapenemase- RT Producing K. pneumoniae: Convergence of Two Evolutionary Mechanisms Creates RT the "Perfect Storm"."; RL J. Infect. Dis. 217:82-92(2017). RN [15] {ECO:0000313|Proteomes:UP000257410, ECO:0000313|Proteomes:UP000257587} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=5012STDY7626396 {ECO:0000313|EMBL:VGJ61364.1, RC ECO:0000313|Proteomes:UP000295133}, EuSCAPE_AT002 RC {ECO:0000313|EMBL:SXG19411.1, ECO:0000313|Proteomes:UP000257587}, RC EuSCAPE_BE105 {ECO:0000313|EMBL:SWU64761.1, RC ECO:0000313|Proteomes:UP000257410}, and EuSCAPE_HU047 RC {ECO:0000313|EMBL:SYR48804.1, ECO:0000313|Proteomes:UP000258253}; RG Pathogen Informatics; RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases. RN [16] {ECO:0000313|EMBL:QOU54602.1, ECO:0000313|Proteomes:UP000439817} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CriePir120 {ECO:0000313|EMBL:QOU54602.1, RC ECO:0000313|Proteomes:UP000439817}; RC PLASMID=unnamed1 {ECO:0000313|EMBL:QOU54602.1, RC ECO:0000313|Proteomes:UP000439817}; RX PubMed=32429555; RA Shelenkov A., Mikhaylova Y., Yanushevich Y., Samoilov A., Petrova L., RA Fomina V., Gusarov V., Zamyatin M., Shagin D., Akimkin V.; RT "Molecular Typing, Characterization of Antimicrobial Resistance, Virulence RT Profiling and Analysis of Whole-Genome Sequence of Clinical Klebsiella RT pneumoniae Isolates."; RL Antibiotics 9:E261-E261(2020). RN [17] {ECO:0000313|EMBL:QJL32362.1, ECO:0000313|Proteomes:UP000503203} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C16KP0122 {ECO:0000313|EMBL:QJL32362.1, RC ECO:0000313|Proteomes:UP000503203}; RC PLASMID=pC16KP0122-2 {ECO:0000313|EMBL:QJL32362.1}, and pc16kp0122-2 RC {ECO:0000313|Proteomes:UP000503203}; RA Yoon E.-J., Gwon B., Liu C., Kim D., Won D., Park S.G., Choi J.R., RA Jeong S.H.; RT "Built-in CTX-M extended-spectrum beta-lactamase gene in Klebsiella RT pneumoniae ensuring stable propagation of the multidrug-resistant pathogen RT in clinical settings."; RL Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the site-specific recombinase resolvase family. CC {ECO:0000256|ARBA:ARBA00009913}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; EU195449; ABY74391.1; -; Genomic_DNA. DR EMBL; FJ223605; ACI62990.1; -; Genomic_DNA. DR EMBL; FJ223607; ACI63186.1; -; Genomic_DNA. DR EMBL; GU585907; ADG84865.1; -; Genomic_DNA. DR EMBL; JX193301; AFZ77109.1; -; Genomic_DNA. DR EMBL; KM977631; AIW55697.1; -; Genomic_DNA. DR EMBL; KF680003; AJR19483.1; -; Genomic_DNA. DR EMBL; KR091915; AKS10512.1; -; Genomic_DNA. DR EMBL; AB616660; BAM28997.1; -; Genomic_DNA. DR EMBL; AB759690; BAN17418.1; -; Genomic_DNA. DR EMBL; HF545435; CCN80147.1; -; Genomic_DNA. DR EMBL; HF955507; CDF32047.1; -; Genomic_DNA. DR EMBL; NCLW01000001; PLD48882.1; -; Genomic_DNA. DR EMBL; CP052433; QJL32362.1; -; Genomic_DNA. DR EMBL; CP063009; QOU54602.1; -; Genomic_DNA. DR EMBL; UJSE01000069; SWU64761.1; -; Genomic_DNA. DR EMBL; UKAW01000052; SXG19411.1; -; Genomic_DNA. DR EMBL; ULCI01000069; SYR48804.1; -; Genomic_DNA. DR EMBL; CAAHAW010000032; VGJ61364.1; -; Genomic_DNA. DR RefSeq; WP_001749988.1; NZ_WXZN01000026.1. DR RefSeq; YP_002286838.1; NC_011383.1. DR RefSeq; YP_002286932.1; NC_011385.1. DR RefSeq; YP_002332849.1; NC_011617.1. DR RefSeq; YP_003813096.1; NC_014368.1. DR RefSeq; YP_007195370.1; NC_019888.1. DR RefSeq; YP_007349714.1; NC_020088.1. DR RefSeq; YP_008145015.1; NC_021622.1. DR EnsemblBacteria; PAX10020; PAX10020; BVX91_28505. DR EnsemblBacteria; PVW83475; PVW83475; B4U30_07675. DR EnsemblBacteria; RDT64563; RDT64563; DXF97_28360. DR EnsemblBacteria; SBY90392; SBY90392; SAMEA3531848_05737. DR EnsemblBacteria; SSG41191; SSG41191; SAMEA23986918_09752. DR GeneID; 72530330; -. DR KEGG; kpb:FH42_26845; -. DR PATRIC; fig|573.1352.peg.5296; -. DR Proteomes; UP000234595; Unassembled WGS sequence. DR Proteomes; UP000257410; Unassembled WGS sequence. DR Proteomes; UP000257587; Unassembled WGS sequence. DR Proteomes; UP000258253; Unassembled WGS sequence. DR Proteomes; UP000295133; Unassembled WGS sequence. DR Proteomes; UP000439817; Plasmid unnamed1. DR Proteomes; UP000503203; Plasmid pc16kp0122-2. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0000150; F:DNA strand exchange activity; IEA:InterPro. DR GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW. DR CDD; cd00569; HTH_Hin_like; 1. DR CDD; cd03768; SR_ResInv; 1. DR Gene3D; 1.10.10.60; Homeodomain-like; 1. DR Gene3D; 3.40.50.1390; Resolvase, N-terminal catalytic domain; 1. DR InterPro; IPR009057; Homeobox-like_sf. DR InterPro; IPR006118; Recombinase_CS. DR InterPro; IPR006119; Resolv_N. DR InterPro; IPR036162; Resolvase-like_N_sf. DR InterPro; IPR006120; Resolvase_HTH_dom. DR PANTHER; PTHR30461; DNA-INVERTASE FROM LAMBDOID PROPHAGE; 1. DR PANTHER; PTHR30461:SF22; SERINE RECOMBINASE PINE-RELATED; 1. DR Pfam; PF02796; HTH_7; 1. DR Pfam; PF00239; Resolvase; 1. DR SMART; SM00857; Resolvase; 1. DR SUPFAM; SSF46689; Homeodomain-like; 1. DR SUPFAM; SSF53041; Resolvase-like; 1. DR PROSITE; PS00398; RECOMBINASES_2; 1. DR PROSITE; PS51736; RECOMBINASES_3; 1. PE 3: Inferred from homology; KW DNA integration {ECO:0000256|ARBA:ARBA00022908}; KW DNA recombination {ECO:0000256|ARBA:ARBA00023172}; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125}; KW Plasmid {ECO:0000313|EMBL:ABY74391.1}. FT DOMAIN 1..140 FT /note="Resolvase/invertase-type recombinase catalytic" FT /evidence="ECO:0000259|PROSITE:PS51736" FT ACT_SITE 9 FT /note="O-(5'-phospho-DNA)-serine intermediate" FT /evidence="ECO:0000256|PIRSR:PIRSR606118-50" SQ SEQUENCE 189 AA; 21131 MW; 5388132D1ABF5A5A CRC64; MKIGYARKST HLQDVAHQVD ELTKAGCEQI YQDQTSRSGP KRDKKGAPEL ENCLKALREG DTLVVWALDR LGGSLGQVIT LLDDLKKRGI TFIAIKDRID TNAPVIGEIY THLMAIFSSF ERNRNIERTR SGLAAARARG RVGGRKPSLS EEDVKQIRIL LADPEMTVGA VAKRFNVSRM TIYRYTTKS //