ID MDM10_TALMQ Reviewed; 477 AA. AC B6Q6B6; DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot. DT 16-DEC-2008, sequence version 1. DT 14-DEC-2022, entry version 56. DE RecName: Full=Mitochondrial distribution and morphology protein 10 {ECO:0000255|HAMAP-Rule:MF_03102}; DE AltName: Full=Mitochondrial inheritance component mdm10 {ECO:0000255|HAMAP-Rule:MF_03102}; GN Name=mdm10; ORFNames=PMAA_033940; OS Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333) OS (Penicillium marneffei). OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes; OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces; OC Talaromyces sect. Talaromyces. OX NCBI_TaxID=441960; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 18224 / CBS 334.59 / QM 7333; RX PubMed=25676766; DOI=10.1128/genomea.01559-14; RA Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.; RT "Genome sequence of the AIDS-associated pathogen Penicillium marneffei RT (ATCC18224) and its near taxonomic relative Talaromyces stipitatus RT (ATCC10500)."; RL Genome Announc. 3:E0155914-E0155914(2015). CC -!- FUNCTION: Component of the ERMES/MDM complex, which serves as a CC molecular tether to connect the endoplasmic reticulum and mitochondria. CC Components of this complex are involved in the control of mitochondrial CC shape and protein biogenesis and may function in phospholipid exchange. CC mdm10 is involved in the late assembly steps of the general translocase CC of the mitochondrial outer membrane (TOM complex). Functions in the CC tom40-specific route of the assembly of outer membrane beta-barrel CC proteins, including the association of tom40 with the receptor tom22 CC and small TOM proteins. Can associate with the SAM(core) complex as CC well as the mdm12-mmm1 complex, both involved in late steps of the CC major beta-barrel assembly pathway, that is responsible for biogenesis CC of all outer membrane beta-barrel proteins. May act as a switch that CC shuttles between both complexes and channels precursor proteins into CC the tom40-specific pathway. Plays a role in mitochondrial morphology CC and in the inheritance of mitochondria. {ECO:0000255|HAMAP- CC Rule:MF_03102}. CC -!- SUBUNIT: Component of the ER-mitochondria encounter structure (ERMES) CC or MDM complex, composed of mmm1, mdm10, mdm12 and mdm34. Associates CC with the mitochondrial outer membrane sorting assembly machinery CC SAM(core) complex. {ECO:0000255|HAMAP-Rule:MF_03102}. CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000255|HAMAP- CC Rule:MF_03102}; Multi-pass membrane protein {ECO:0000255|HAMAP- CC Rule:MF_03102}. Note=The ERMES/MDM complex localizes to a few discrete CC foci (around 10 per single cell), that represent mitochondria- CC endoplasmic reticulum junctions. These foci are often found next to CC mtDNA nucleoids. {ECO:0000255|HAMAP-Rule:MF_03102}. CC -!- DOMAIN: Lacks alpha-helical transmembrane segments, suggesting that it CC resides in the membrane via beta-sheet conformations similar to those CC predicted for other outer membrane proteins and porin. CC -!- SIMILARITY: Belongs to the MDM10 family. {ECO:0000255|HAMAP- CC Rule:MF_03102}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DS995899; EEA28591.1; -; Genomic_DNA. DR RefSeq; XP_002145106.1; XM_002145070.1. DR AlphaFoldDB; B6Q6B6; -. DR SMR; B6Q6B6; -. DR STRING; 441960.B6Q6B6; -. DR GeneID; 7022843; -. DR KEGG; tmf:PMAA_033940; -. DR VEuPathDB; FungiDB:PMAA_033940; -. DR HOGENOM; CLU_026505_1_0_1; -. DR OrthoDB; 1463552at2759; -. DR PhylomeDB; B6Q6B6; -. DR Proteomes; UP000001294; Unassembled WGS sequence. DR GO; GO:0032865; C:ERMES complex; IEA:UniProtKB-UniRule. DR GO; GO:0000002; P:mitochondrial genome maintenance; IEA:UniProtKB-UniRule. DR GO; GO:0070096; P:mitochondrial outer membrane translocase complex assembly; IEA:UniProtKB-UniRule. DR GO; GO:1990456; P:mitochondrion-endoplasmic reticulum membrane tethering; IEA:UniProtKB-UniRule. DR GO; GO:0045040; P:protein insertion into mitochondrial outer membrane; IEA:UniProtKB-UniRule. DR HAMAP; MF_03102; Mdm10; 1. DR InterPro; IPR027539; Mdm10. DR PANTHER; PTHR28035; MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 10; 1. DR Pfam; PF12519; MDM10; 2. PE 3: Inferred from homology; KW Membrane; Mitochondrion; Mitochondrion outer membrane; Reference proteome; KW Transmembrane; Transmembrane beta strand. FT CHAIN 1..477 FT /note="Mitochondrial distribution and morphology protein FT 10" FT /id="PRO_0000384190" FT REGION 430..465 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 477 AA; 50884 MW; 5B5935DD4F70A53E CRC64; MLEFMDYVQL AFAEATRWNQ DNSYSALTAT AESLLDFHVP ERLQVRLSSL STPHFATSYT LGTVGLIDGS VSYLFSTVPL NNTPSQSGLI PLRRLVRGYR QIEAPVPPRR NWGWDAIPSP NSLQNIDGAE NNDDVVRKAT LLHATLHLPP PSTLNALFLR RISPTTQITA SLVSTQAPPL VKSAPSAALL AQISHDTGTF SNEYLFSTDN ALFGWRGLWN IGLEPAPGKA STDKVSLLSA GAEAYYSPIS SLVGLSTGLK FTTLPAASRT PSSSSSGSTP NPISSFPYTL TLTLTPLTGS LSTTYSARAS PNLAFSSRFG FNVYSWESEM VAGCEIWRKS PRTEPVEVDD GLEWARRKMG IVKDLAAEKI SSLSSSNNPQ AIEEDEGDSV IKIRVDQSWN VRLLWEGRVK SLLVTAGVSL GPGSFTALSS IPSSPTSSSA PVAAAGTGSS QSSGGGAAPT SRPSYWQGVG VSILYSS //