ID ERA_HELP2 Reviewed; 301 AA. AC B6JL99; DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot. DT 16-DEC-2008, sequence version 1. DT 22-FEB-2012, entry version 23. DE RecName: Full=GTPase Era; GN Name=era; OrderedLocusNames=HPP12_0523; OS Helicobacter pylori (strain P12). OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales; OC Helicobacteraceae; Helicobacter. OX NCBI_TaxID=570508; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=P12; RA Fischer W., Windhager L., Karnholz A., Zeiller M., Zimmer R., Haas R.; RT "The complete genome sequence of Helicobacter pylori strain P12."; RL Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: An essential GTPase that binds both GDP and GTP, with CC rapid nucleotide exchange. Plays a role in 16S rRNA processing and CC 30S ribosomal subunit biogenesis and possibly also in cell cycle CC regulation and energy metabolism (By similarity). CC -!- SUBUNIT: Monomer (By similarity). CC -!- SUBCELLULAR LOCATION: Cytoplasm. Cell inner membrane; Peripheral CC membrane protein (By similarity). CC -!- SIMILARITY: Belongs to the Era/MnmE GTP-binding protein family. CC Era subfamily. CC -!- SIMILARITY: Contains 1 G (guanine nucleotide-binding) domain. CC -!- SIMILARITY: Contains 1 KH type-2 domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP001217; ACJ07677.1; -; Genomic_DNA. DR RefSeq; YP_002301157.1; NC_011498.1. DR ProteinModelPortal; B6JL99; -. DR STRING; B6JL99; -. DR GeneID; 7010898; -. DR GenomeReviews; CP001217_GR; HPP12_0523. DR KEGG; hpp:HPP12_0523; -. DR PATRIC; 20609024; VBIHelPyl2824_0552. DR eggNOG; COG1159; -. DR HOGENOM; HBG561652; -. DR KO; K03595; -. DR OMA; KVAKDWQ; -. DR ProtClustDB; PRK00089; -. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW. DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW. DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW. DR HAMAP; MF_00367; GTPase_Era; 1; -. DR InterPro; IPR005662; GTP-bd_Era. DR InterPro; IPR006073; GTP_binding_domain. DR InterPro; IPR015946; KH_dom-like_a/b. DR InterPro; IPR009019; KH_prok-type. DR InterPro; IPR004044; KH_type_2. DR InterPro; IPR005225; Small_GTP-bd_dom. DR Gene3D; G3DSA:3.30.300.20; KH_prok; 1. DR Pfam; PF07650; KH_2; 1. DR Pfam; PF01926; MMR_HSR1; 1. DR SUPFAM; SSF54814; KH_prok; 1. DR TIGRFAMs; TIGR00436; Era; 1. DR TIGRFAMs; TIGR00231; Small_GTP; 1. DR PROSITE; PS50823; KH_TYPE_2; 1. PE 3: Inferred from homology; KW Cell inner membrane; Cell membrane; Complete proteome; Cytoplasm; KW GTP-binding; Membrane; Nucleotide-binding; Ribosome biogenesis; KW RNA-binding; rRNA-binding. FT CHAIN 1 301 GTPase Era. FT /FTId=PRO_1000121331. FT DOMAIN 17 123 G. FT DOMAIN 204 280 KH type-2. FT NP_BIND 12 19 GTP (Potential). FT NP_BIND 64 68 GTP (Potential). FT NP_BIND 122 125 GTP (Potential). SQ SEQUENCE 301 AA; 34422 MW; 92994DE2DA728BB5 CRC64; MKTKAGFVAL IGKPNAGKST LLNTLLNAHL ALVSHKANAT RKLMKCIVPF KDKEGYESQI IFLDTPGLHH QEKLLNQCML SQALKAMGDA ELCVFLASVH DDLKGYEEFL SLCQKPHILA LSKIDTATHK QVLQKLQEYQ QYDSQFLALV PLSAKKSQNL NALLECISKH LNPSAWLFEK DLMSDEKMRD IYKEIIRESL FDFLSDEIPY ESDVMIDKFI EEERIDKVYA RIIVEKESQK KIVIGKNGVN IKRIGTSARL KMQEVGEKKV FLNLQVIAQK SWSKEEKSLQ KLGYTHQRNR D //