ID B6I6D6_ECOSE Unreviewed; 159 AA. AC B6I6D6; DT 16-DEC-2008, integrated into UniProtKB/TrEMBL. DT 16-DEC-2008, sequence version 1. DT 03-MAR-2009, entry version 3. DE SubName: Full=2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; GN OrderedLocusNames=ECSE_2998; OS Escherichia coli (strain SE11). OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; OC Enterobacteriaceae; Escherichia. OX NCBI_TaxID=409438; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=18931093; DOI=10.1093/dnares/dsn026; RA Oshima K., Toh H., Ogura Y., Sasamoto H., Morita H., Park S.-H., RA Ooka T., Iyoda S., Taylor T.D., Hayashi T., Itoh K., Hattori M.; RT "Complete genome sequence and comparative analysis of the wild-type RT commensal Escherichia coli strain SE11 isolated from a healthy RT adult."; RL DNA Res. 15:375-386(2008). CC -!- FUNCTION: Converts 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- CC phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate CC (MECDP) and CMP. CC -!- CATALYTIC ACTIVITY: 2-phospho-4-(cytidine 5'-diphospho)-2-C- CC methyl-D-erythritol = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate CC + CMP. CC -!- COFACTOR: Binds 1 divalent metal cation per subunit. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AP009240; BAG78522.1; -; Genomic_DNA. DR RefSeq; YP_002294273.1; -. DR GeneID; 7001383; -. DR GO; GO:0008685; F:2-C-methyl-D-erythritol 2,4-cyclodiphosphat...; IEA:InterPro. DR GO; GO:0016114; P:terpenoid biosynthetic process; IEA:InterPro. DR InterPro; IPR003526; MECDP_synthase_core. DR Gene3D; G3DSA:3.30.1330.50; MECDP_synthase_core; 1. DR Pfam; PF02542; YgbB; 1. DR TIGRFAMs; TIGR00151; ispF; 1. DR PROSITE; PS01350; ISPF; 1. PE 4: Predicted; KW Complete proteome; Isoprene biosynthesis; Lyase; Metal-binding. SQ SEQUENCE 159 AA; 16898 MW; 9FC5563623A62939 CRC64; MRIGHGFDVH AFGGEGPIII GGVRIPYEKG LLAHSDGDVA LHALTDALLG AAALGDIGKL FPDTDPAFKG ADSRELLREA WRRIQAKGYT LGNVDVTIIA QAPKMLPHIP QMRVFIAEDL GCHMDDVNVK ATTTEKLGFT GRGEGIACEA VALLIKATK //