ID   B6I6D6_ECOSE            Unreviewed;       159 AA.
AC   B6I6D6;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 1.
DT   03-MAR-2009, entry version 3.
DE   SubName: Full=2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase;
GN   OrderedLocusNames=ECSE_2998;
OS   Escherichia coli (strain SE11).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=409438;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=18931093; DOI=10.1093/dnares/dsn026;
RA   Oshima K., Toh H., Ogura Y., Sasamoto H., Morita H., Park S.-H.,
RA   Ooka T., Iyoda S., Taylor T.D., Hayashi T., Itoh K., Hattori M.;
RT   "Complete genome sequence and comparative analysis of the wild-type
RT   commensal Escherichia coli strain SE11 isolated from a healthy
RT   adult.";
RL   DNA Res. 15:375-386(2008).
CC   -!- FUNCTION: Converts 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-
CC       phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate
CC       (MECDP) and CMP.
CC   -!- CATALYTIC ACTIVITY: 2-phospho-4-(cytidine 5'-diphospho)-2-C-
CC       methyl-D-erythritol = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate
CC       + CMP.
CC   -!- COFACTOR: Binds 1 divalent metal cation per subunit.
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DR   EMBL; AP009240; BAG78522.1; -; Genomic_DNA.
DR   RefSeq; YP_002294273.1; -.
DR   GeneID; 7001383; -.
DR   GO; GO:0008685; F:2-C-methyl-D-erythritol 2,4-cyclodiphosphat...; IEA:InterPro.
DR   GO; GO:0016114; P:terpenoid biosynthetic process; IEA:InterPro.
DR   InterPro; IPR003526; MECDP_synthase_core.
DR   Gene3D; G3DSA:3.30.1330.50; MECDP_synthase_core; 1.
DR   Pfam; PF02542; YgbB; 1.
DR   TIGRFAMs; TIGR00151; ispF; 1.
DR   PROSITE; PS01350; ISPF; 1.
PE   4: Predicted;
KW   Complete proteome; Isoprene biosynthesis; Lyase; Metal-binding.
SQ   SEQUENCE   159 AA;  16898 MW;  9FC5563623A62939 CRC64;
     MRIGHGFDVH AFGGEGPIII GGVRIPYEKG LLAHSDGDVA LHALTDALLG AAALGDIGKL
     FPDTDPAFKG ADSRELLREA WRRIQAKGYT LGNVDVTIIA QAPKMLPHIP QMRVFIAEDL
     GCHMDDVNVK ATTTEKLGFT GRGEGIACEA VALLIKATK
//