ID   B6H451_PENRW            Unreviewed;       525 AA.
AC   B6H451;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 1.
DT   16-MAR-2016, entry version 60.
DE   RecName: Full=Inosine-5'-monophosphate dehydrogenase {ECO:0000256|RuleBase:RU003928};
DE            EC=1.1.1.205 {ECO:0000256|RuleBase:RU003928};
GN   ORFNames=Pc13g07630 {ECO:0000313|EMBL:CAP91832.1}, PCH_Pc13g07630
GN   {ECO:0000313|EMBL:CAP91832.1};
OS   Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 /
OS   Wisconsin 54-1255) (Penicillium chrysogenum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC   Penicillium chrysogenum complex.
OX   NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP91832.1, ECO:0000313|Proteomes:UP000000724};
RN   [1] {ECO:0000313|EMBL:CAP91832.1, ECO:0000313|Proteomes:UP000000724}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC   {ECO:0000313|Proteomes:UP000000724};
RX   PubMed=18820685; DOI=10.1038/nbt.1498;
RA   van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA   Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA   Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA   Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A.,
RA   van der Klei I.J., van Peij N.N.M.E., Veenhuis M., von Doehren H.,
RA   Wagner C., Wortman J.R., Bovenberg R.A.L.;
RT   "Genome sequencing and analysis of the filamentous fungus Penicillium
RT   chrysogenum.";
RL   Nat. Biotechnol. 26:1161-1168(2008).
CC   -!- CATALYTIC ACTIVITY: Inosine 5'-phosphate + NAD(+) + H(2)O =
CC       xanthosine 5'-phosphate + NADH. {ECO:0000256|RuleBase:RU003928}.
CC   -!- PATHWAY: Purine metabolism; XMP biosynthesis via de novo pathway;
CC       XMP from IMP: step 1/1. {ECO:0000256|RuleBase:RU003928}.
CC   -!- SIMILARITY: Belongs to the IMPDH/GMPR family.
CC       {ECO:0000256|RuleBase:RU003927}.
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DR   EMBL; AM920428; CAP91832.1; -; Genomic_DNA.
DR   RefSeq; XP_002559192.1; XM_002559146.1.
DR   ProteinModelPortal; B6H451; -.
DR   STRING; 500485.XP_002559192.1; -.
DR   EnsemblFungi; CAP91832; CAP91832; PCH_Pc13g07630.
DR   GeneID; 8309924; -.
DR   KEGG; pcs:Pc13g07630; -.
DR   eggNOG; KOG2550; Eukaryota.
DR   eggNOG; COG0516; LUCA.
DR   eggNOG; COG0517; LUCA.
DR   HOGENOM; HOG000165752; -.
DR   KO; K00088; -.
DR   OMA; KQITMKT; -.
DR   OrthoDB; EOG793BHK; -.
DR   BioCyc; PCHR:PC13G07630-MONOMER; -.
DR   UniPathway; UPA00601; UER00295.
DR   Proteomes; UP000000724; Contig Pc00c13.
DR   GO; GO:0003938; F:IMP dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006177; P:GMP biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_01964; IMPDH; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR005990; IMP_DH.
DR   InterPro; IPR015875; IMP_DH/GMP_Rdtase_CS.
DR   InterPro; IPR001093; IMP_DH_GMPRt.
DR   PANTHER; PTHR11911:SF6; PTHR11911:SF6; 2.
DR   Pfam; PF00571; CBS; 2.
DR   Pfam; PF00478; IMPDH; 1.
DR   PIRSF; PIRSF000130; IMPDH; 1.
DR   SMART; SM00116; CBS; 2.
DR   TIGRFAMs; TIGR01302; IMP_dehydrog; 1.
DR   PROSITE; PS51371; CBS; 2.
DR   PROSITE; PS00487; IMP_DH_GMP_RED; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000724};
KW   GMP biosynthesis {ECO:0000256|RuleBase:RU003928};
KW   Metal-binding {ECO:0000256|RuleBase:RU003928};
KW   NAD {ECO:0000256|PIRSR:PIRSR000130-3, ECO:0000256|RuleBase:RU003928};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU003927};
KW   Potassium {ECO:0000256|PIRSR:PIRSR000130-4,
KW   ECO:0000256|RuleBase:RU003928};
KW   Purine biosynthesis {ECO:0000256|RuleBase:RU003928};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000724}.
FT   DOMAIN      120    179       CBS. {ECO:0000259|PROSITE:PS51371}.
FT   DOMAIN      183    239       CBS. {ECO:0000259|PROSITE:PS51371}.
FT   NP_BIND     276    278       NAD. {ECO:0000256|PIRSR:PIRSR000130-3}.
FT   NP_BIND     326    328       NAD. {ECO:0000256|PIRSR:PIRSR000130-3}.
FT   ACT_SITE    333    333       Thioimidate intermediate.
FT                                {ECO:0000256|PIRSR:PIRSR000130-1}.
FT   ACT_SITE    439    439       Proton acceptor. {ECO:0000256|PIRSR:
FT                                PIRSR000130-1}.
FT   METAL       328    328       Potassium; via carbonyl oxygen.
FT                                {ECO:0000256|PIRSR:PIRSR000130-4}.
FT   METAL       330    330       Potassium; via carbonyl oxygen.
FT                                {ECO:0000256|PIRSR:PIRSR000130-4}.
FT   METAL       333    333       Potassium; via carbonyl oxygen.
FT                                {ECO:0000256|PIRSR:PIRSR000130-4}.
SQ   SEQUENCE   525 AA;  55770 MW;  32FB96F633F21DED CRC64;
     MVEVLDYTKA LEVLKEYPGD GLHVDTLLDS DSHGALTYND FLILPGSITF PASDVSLETK
     VTRRFTIKAP LLSSPMDTVT EHSMAIHMAL LGGLGVIHNN CPPDEQAEMV RKVKRYENGF
     IQDPIVLSPE TTVGEAKELK TKWGFGGFPV TEKGTLLSKL LGIVTSRDIQ FHKNHEDPVT
     AVMMTDLVTA PAGTTLAEAN EVLRSSKKGK LPIVDKDGSL ISLLSRSDLM KNIHYPLASK
     LPSKQLLCAA AISTHDADKV RLEKLVDAGL DIVVVDSSQG HSIFQIAMIK YIKQTFPDID
     VIGGNIVTRE QAAALIAAGA DGLRIGMGSG SACITQEVMA AGRPQAAAVR SVSAFAARFG
     VPTIADGGVQ NLGHIVKGLA LGASAVMMGS LLAGTTESPG EYFMSSEGQL VKAFRGMGSI
     AVMEDKSKSG AGNNAGASRY FSENDKVKVA QGVAGSVIDR GSITQYVPYL VAGVQHSLQD
     IGVQNLDALR DGVNNGTVRF EMRSASAQTE GNVHGLHTHE KKLYS
//