ID TX113_LYCSI Reviewed; 107 AA. AC B6DCK2; DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot. DT 25-NOV-2008, sequence version 1. DT 11-DEC-2019, entry version 15. DE RecName: Full=U1-lycotoxin-Ls1b; DE AltName: Full=Toxin-like structure LSTX-A13; DE Flags: Precursor; OS Lycosa singoriensis (Wolf spider) (Aranea singoriensis). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae; OC Araneomorphae; Entelegynae; Lycosoidea; Lycosidae; Lycosa. OX NCBI_TaxID=434756; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Venom gland; RX PubMed=19875276; DOI=10.1016/j.zool.2009.04.001; RA Zhang Y., Chen J., Tang X., Wang F., Jiang L., Xiong X., Wang M., Rong M., RA Liu Z., Liang S.; RT "Transcriptome analysis of the venom glands of the Chinese wolf spider RT Lycosa singoriensis."; RL Zoology 113:10-18(2010). CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. CC -!- TISSUE SPECIFICITY: Expressed by the venom gland. CC -!- DOMAIN: The presence of a 'disulfide through disulfide knot' CC structurally defines this protein as a knottin. {ECO:0000250}. CC -!- SIMILARITY: Belongs to the neurotoxin 19 (CSTX) family. 04 (U1-Lctx) CC subfamily. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; EU925936; ACI41268.1; -; mRNA. DR EMBL; FM863940; CAS03538.1; -; mRNA. DR SMR; B6DCK2; -. DR ArachnoServer; AS000884; U1-lycotoxin-Ls1b. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW. DR GO; GO:0009405; P:pathogenesis; IEA:GOC. DR InterPro; IPR019553; Spider_toxin_CSTX_knottin. DR InterPro; IPR011142; Spider_toxin_CSTX_Knottin_CS. DR Pfam; PF10530; Toxin_35; 1. DR PROSITE; PS60029; SPIDER_CSTX; 1. PE 2: Evidence at transcript level; KW Disulfide bond; Knottin; Secreted; Signal; Toxin. FT SIGNAL 1..20 FT /evidence="ECO:0000255" FT PROPEP 21..41 FT /evidence="ECO:0000250" FT /id="PRO_0000401523" FT CHAIN 42..107 FT /note="U1-lycotoxin-Ls1b" FT /id="PRO_0000401524" FT DISULFID 44..59 FT /evidence="ECO:0000250" FT DISULFID 51..68 FT /evidence="ECO:0000250" FT DISULFID 58..86 FT /evidence="ECO:0000250" FT DISULFID 70..84 FT /evidence="ECO:0000250" SQ SEQUENCE 107 AA; 11854 MW; 59B5828113A0D518 CRC64; MMKVLVVVAL LATLISYSSS EGIDDLEADE LLSLMANEQT RKECIPKHHE CTSNKHGCCR GNFFKYKCQC TTVVTQDGEQ TERCFCGTPP HHKAAELVVG FGKKIFG //