ID SLMA_ECO5E Reviewed; 198 AA. AC B5YWD9; DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot. DT 25-NOV-2008, sequence version 1. DT 03-OCT-2012, entry version 36. DE RecName: Full=Nucleoid occlusion factor SlmA; GN Name=slmA; OrderedLocusNames=ECH74115_5011; OS Escherichia coli O157:H7 (strain EC4115 / EHEC). OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; OC Enterobacteriaceae; Escherichia. OX NCBI_TaxID=444450; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=EC4115 / EHEC; RA Eppinger M., Sebastian Y., Ravel J.; RT "Complete genome sequence of Escherichia coli O157:H7 str. EC4115."; RL Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Required for nucleoid occlusion (NO) phenomenon, which CC prevents Z-ring formation and cell division over the nucleoid. CC Acts as a DNA-associated cell division inhibitor that binds CC simultaneously chromosomal DNA and FtsZ, and disrupts the assembly CC of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed CC on non-Ter regions of the chromosome, preventing FtsZ CC polymerization at these regions (By similarity). CC -!- SUBUNIT: Homodimer (By similarity). Interacts with FtsZ (By CC similarity). CC -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid (By similarity). CC -!- SIMILARITY: Belongs to the nucleoid occlusion factor SlmA family. CC -!- SIMILARITY: Contains 1 HTH tetR-type DNA-binding domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP001164; ACI38750.1; -; Genomic_DNA. DR RefSeq; YP_002273119.1; NC_011353.1. DR ProteinModelPortal; B5YWD9; -. DR SMR; B5YWD9; 9-198. DR STRING; B5YWD9; -. DR EnsemblBacteria; EBESCT00000034597; EBESCP00000033300; EBESCG00000033647. DR GeneID; 6967229; -. DR GenomeReviews; CP001164_GR; ECH74115_5011. DR KEGG; ecf:ECH74115_5011; -. DR PATRIC; 18370587; VBIEscCol74651_4907. DR eggNOG; COG1309; -. DR HOGENOM; HOG000266053; -. DR KO; K05501; -. DR OMA; EKDTSAR; -. DR ProtClustDB; PRK09480; -. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW. DR GO; GO:0009295; C:nucleoid; IEA:UniProtKB-SubCell. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW. DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW. DR Gene3D; G3DSA:1.10.357.10; TetR_C; 1. DR HAMAP; MF_01839; NO_factor_SlmA; 1; -. DR InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS. DR InterPro; IPR009057; Homeodomain-like. DR InterPro; IPR001647; HTH_TetR. DR InterPro; IPR023769; NO_SlmA. DR InterPro; IPR015893; Tet_transcr_reg_TetR-like_C. DR InterPro; IPR011075; Tet_transcr_reg_TetR-rel_C. DR Pfam; PF00440; TetR_N; 1. DR SUPFAM; SSF46689; Homeodomain_like; 1. DR SUPFAM; SSF48498; TetR_like_C; 1. DR PROSITE; PS01081; HTH_TETR_1; 1. DR PROSITE; PS50977; HTH_TETR_2; 1. PE 3: Inferred from homology; KW Cell cycle; Cell division; Coiled coil; Complete proteome; Cytoplasm; KW DNA-binding. FT CHAIN 1 198 Nucleoid occlusion factor SlmA. FT /FTId=PRO_1000188381. FT DOMAIN 10 70 HTH tetR-type. FT DNA_BIND 33 52 H-T-H motif (By similarity). FT COILED 117 144 Potential. SQ SEQUENCE 198 AA; 22836 MW; C797B0E2875B0E39 CRC64; MAEKQTAKRN RREEILQSLA LMLESSDGSQ RITTAKLAAS VGVSEAALYR HFPSKTRMFD SLIEFIEDSL ITRINLILKD EKDTTARLRL IVLLLLGFGE RNPGLTRILT GHALMFEQDR LQGRINQLFE RIEAQLRQVL REKRMREGEG YTTDETLLAS QILAFCEGML SRFVRSEFKY RPTDDFDARW PLIAAQLQ //