ID   SLMA_ECO5E              Reviewed;         198 AA.
AC   B5YWD9;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   25-JAN-2012, entry version 30.
DE   RecName: Full=Nucleoid occlusion factor SlmA;
GN   Name=slmA; OrderedLocusNames=ECH74115_5011;
OS   Escherichia coli O157:H7 (strain EC4115 / EHEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=444450;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EC4115 / EHEC;
RA   Eppinger M., Sebastian Y., Ravel J.;
RT   "Complete genome sequence of Escherichia coli O157:H7 str. EC4115.";
RL   Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for nucleoid occlusion (NO) phenomenon, which
CC       prevents Z-ring formation and cell division over the nucleoid.
CC       Acts as a DNA-associated cell division inhibitor that binds
CC       simultaneously chromosomal DNA and FtsZ, and disrupts the assembly
CC       of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed
CC       on non-Ter regions of the chromosome, preventing FtsZ
CC       polymerization at these regions (By similarity).
CC   -!- SUBUNIT: Homodimer (By similarity). Interacts with FtsZ (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid (By similarity).
CC   -!- SIMILARITY: Belongs to the nucleoid occlusion factor SlmA family.
CC   -!- SIMILARITY: Contains 1 HTH tetR-type DNA-binding domain.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP001164; ACI38750.1; -; Genomic_DNA.
DR   RefSeq; YP_002273119.1; NC_011353.1.
DR   ProteinModelPortal; B5YWD9; -.
DR   SMR; B5YWD9; 9-198.
DR   STRING; B5YWD9; -.
DR   EnsemblBacteria; EBESCT00000034597; EBESCP00000033300; EBESCG00000033647.
DR   GeneID; 6967229; -.
DR   GenomeReviews; CP001164_GR; ECH74115_5011.
DR   KEGG; ecf:ECH74115_5011; -.
DR   PATRIC; 18370587; VBIEscCol74651_4907.
DR   GeneTree; EBGT00050000010889; -.
DR   HOGENOM; HBG297015; -.
DR   OMA; YRPTQEF; -.
DR   ProtClustDB; PRK09480; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0009295; C:nucleoid; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   HAMAP; MF_01839; NO_factor_SlmA; 1; -.
DR   InterPro; IPR023769; Cell_div_inh_SlmA.
DR   InterPro; IPR001647; DNA-bd_HTH_TetR-type.
DR   InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR   InterPro; IPR009057; Homeodomain-like.
DR   InterPro; IPR015893; Tet_transcr_reg_TetR-like_C.
DR   InterPro; IPR011075; Tet_transcr_reg_TetR-rel_C.
DR   Gene3D; G3DSA:1.10.357.10; TetR_C; 1.
DR   KO; K05501; -.
DR   Pfam; PF00440; TetR_N; 1.
DR   SUPFAM; SSF46689; Homeodomain_like; 1.
DR   SUPFAM; SSF48498; TetR_like_C; 1.
DR   PROSITE; PS01081; HTH_TETR_1; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Coiled coil; Complete proteome; Cytoplasm;
KW   DNA-binding.
FT   CHAIN         1    198       Nucleoid occlusion factor SlmA.
FT                                /FTId=PRO_1000188381.
FT   DOMAIN       10     70       HTH tetR-type.
FT   DNA_BIND     33     52       H-T-H motif (By similarity).
FT   COILED      117    144       Potential.
SQ   SEQUENCE   198 AA;  22836 MW;  C797B0E2875B0E39 CRC64;
     MAEKQTAKRN RREEILQSLA LMLESSDGSQ RITTAKLAAS VGVSEAALYR HFPSKTRMFD
     SLIEFIEDSL ITRINLILKD EKDTTARLRL IVLLLLGFGE RNPGLTRILT GHALMFEQDR
     LQGRINQLFE RIEAQLRQVL REKRMREGEG YTTDETLLAS QILAFCEGML SRFVRSEFKY
     RPTDDFDARW PLIAAQLQ
//