ID SLMA_ECO5E Reviewed; 198 AA. AC B5YWD9; DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot. DT 25-NOV-2008, sequence version 1. DT 19-JAN-2010, entry version 14. DE RecName: Full=HTH-type protein slmA; GN Name=slmA; OrderedLocusNames=ECH74115_5011; OS Escherichia coli O157:H7 (strain EC4115 / EHEC). OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; OC Enterobacteriaceae; Escherichia. OX NCBI_TaxID=444450; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Eppinger M., Sebastian Y., Ravel J.; RT "Complete genome sequence of Escherichia coli O157:H7 str. EC4115."; RL Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Required for nucleoid occlusion (NO) phenomenon, which CC cooperates in the proper positioning of the ftsZ/septal ring at CC midcell during cell division. Acts as a DNA-associated division CC inhibitor directly involved in preventing Z ring assembly on CC portions of the membrane surrounding the nucleoid (By similarity). CC -!- SUBUNIT: Interacts with ftsZ (By similarity). CC -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid (By similarity). CC -!- SIMILARITY: Contains 1 HTH tetR-type DNA-binding domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP001164; ACI38750.1; -; Genomic_DNA. DR RefSeq; YP_002273119.1; -. DR SMR; B5YWD9; 11-183. DR GeneID; 6967229; -. DR GenomeReviews; CP001164_GR; ECH74115_5011. DR KEGG; ecf:ECH74115_5011; -. DR HOGENOM; HBG297015; -. DR OMA; KMREGEG; -. DR GO; GO:0005737; C:cytoplasm; IEA:HAMAP. DR GO; GO:0009295; C:nucleoid; IEA:UniProtKB-SubCell. DR GO; GO:0003700; F:transcription factor activity; IEA:InterPro. DR GO; GO:0000917; P:barrier septum formation; IEA:HAMAP. DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW. DR GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro. DR GO; GO:0006350; P:transcription; IEA:UniProtKB-KW. DR HAMAP; MF_01839; HTH-type_SlmA; 1; -. DR InterPro; IPR009057; Homeodomain-like. DR InterPro; IPR012287; Homeodomain-rel. DR InterPro; IPR011075; Tet_transcr_reg_TetR-rel_C. DR InterPro; IPR001647; Transcr-reg_TetR-like_bac/arc. DR Gene3D; G3DSA:1.10.10.60; Homeodomain-rel; 1. DR Pfam; PF00440; TetR_N; 1. DR PROSITE; PS01081; HTH_TETR_1; 1. DR PROSITE; PS50977; HTH_TETR_2; 1. PE 3: Inferred from homology; KW Cell cycle; Cell division; Complete proteome; Cytoplasm; DNA-binding; KW Transcription; Transcription regulation. FT CHAIN 1 198 HTH-type protein slmA. FT /FTId=PRO_1000188381. FT DOMAIN 10 70 HTH tetR-type. FT DNA_BIND 33 52 H-T-H motif (By similarity). SQ SEQUENCE 198 AA; 22836 MW; C797B0E2875B0E39 CRC64; MAEKQTAKRN RREEILQSLA LMLESSDGSQ RITTAKLAAS VGVSEAALYR HFPSKTRMFD SLIEFIEDSL ITRINLILKD EKDTTARLRL IVLLLLGFGE RNPGLTRILT GHALMFEQDR LQGRINQLFE RIEAQLRQVL REKRMREGEG YTTDETLLAS QILAFCEGML SRFVRSEFKY RPTDDFDARW PLIAAQLQ //