ID B5SN27_9INFA Unreviewed; 96 AA. AC B5SN27; DT 04-NOV-2008, integrated into UniProtKB/TrEMBL. DT 04-NOV-2008, sequence version 1. DT 01-SEP-2009, entry version 10. DE SubName: Full=Matrix protein 2; DE Flags: Fragment; GN Name=M2; OS Influenza A virus (A/turkey/England/N28/1973(H5N2)). OC Viruses; ssRNA negative-strand viruses; Orthomyxoviridae; OC Influenzavirus A. OX NCBI_TaxID=511839; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=A/turkey/England/N28/1973; RX PubMed=18774155; DOI=10.1016/j.virol.2008.07.038; RA Duan L., Bahl J., Smith G.J., Wang J., Vijaykrishna D., Zhang L.J., RA Zhang J.X., Li K.S., Fan X.H., Cheung C.L., Huang K., Poon L.L., RA Shortridge K.F., Webster R.G., Peiris J.S., Chen H., Guan Y.; RT "The development and genetic diversity of H5N1 influenza virus in RT China, 1996-2006."; RL Virology 380:243-254(2008). CC -!- FUNCTION: Forms a proton-selective ion channel that is necessary CC for the efficient release of the viral genome during virus entry. CC After attaching to the cell surface, the virion enters the cell by CC endocytosis. Acidification of the endosome triggers M2 ion channel CC activity. The influx of protons into virion interior is believed CC to disrupt interactions between the viral ribonucleoprotein (RNP), CC matrix protein 1 (M1), and lipid bilayers, thereby freeing the CC viral genome from interaction with viral proteins and enabling RNA CC segments to migrate to the host cell nucleus, where influenza CC virus RNA transcription and replication occur. Also plays a role CC in viral proteins secretory pathway. Elevates the intravesicular CC pH of normally acidic compartments, such as trans-Golgi network, CC preventing newly formed hemagglutinin from premature switching to CC the fusion-active conformation (By similarity). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CY030996; ACH85535.1; -; Viral_cRNA. DR GO; GO:0033644; C:host cell membrane; IEA:InterPro. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW. DR GO; GO:0055036; C:virion membrane; IEA:InterPro. DR GO; GO:0015078; F:hydrogen ion transmembrane transporter acti...; IEA:UniProtKB-KW. DR GO; GO:0005216; F:ion channel activity; IEA:UniProtKB-KW. DR GO; GO:0015992; P:proton transport; IEA:UniProtKB-KW. DR InterPro; IPR002089; Flu_M2. DR Pfam; PF00599; Flu_M2; 1. PE 3: Inferred from homology; KW Cell membrane; Hydrogen ion transport; Ion transport; Ionic channel; KW Membrane; Transmembrane; Transport; Virion. FT NON_TER 1 1 FT NON_TER 96 96 SQ SEQUENCE 96 AA; 11015 MW; 85D85665BDB61B98 CRC64; SLLTEVETPT RNGWECKCSD SSDPLVTAAS IIGILHLILW ILDRLFFKCI YRRLKYGLKR GPSTEGVPES MREEYRQEQQ SAVDVDDGHF VNIELE //