ID B5LY71_HUMAN Unreviewed; 480 AA. AC B5LY71; DT 14-OCT-2008, integrated into UniProtKB/TrEMBL. DT 14-OCT-2008, sequence version 1. DT 18-APR-2012, entry version 23. DE SubName: Full=Uridine monophosphate synthetase isoform I; GN Name=UMPS; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RA Griffith M., Pugh T.J., Tang M.J., Asano J.K., Ally A., Chan S.Y., RA Taylor G., Morin G.B., Tai I.T., Marra M.A.; RT "Genomic analysis of UMPS expression and sequence reveals novel RT isoforms and sequence polymorphisms associated with 5-FU resistance."; RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; EU921894; ACH48232.1; -; mRNA. DR IPI; IPI00003923; -. DR UniGene; Hs.2057; -. DR STRING; B5LY71; -. DR PRIDE; B5LY71; -. DR HOVERGEN; HBG000870; -. DR GO; GO:0004588; F:orotate phosphoribosyltransferase activity; IEA:InterPro. DR GO; GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:InterPro. DR GO; GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IEA:InterPro. DR GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:InterPro. DR HAMAP; MF_01208; PyrE; 1; -. DR InterPro; IPR013785; Aldolase_TIM. DR InterPro; IPR014732; OMPdecase. DR InterPro; IPR018089; OMPdecase_AS. DR InterPro; IPR001754; OMPdeCOase_dom. DR InterPro; IPR004467; Or_phspho_trans_clade-1. DR InterPro; IPR023031; Orotate_PribosylTferase. DR InterPro; IPR000836; PRibTrfase. DR InterPro; IPR011060; RibuloseP-bd_barrel. DR Gene3D; G3DSA:3.20.20.70; Aldolase_TIM; 1. DR Pfam; PF00215; OMPdecase; 1. DR Pfam; PF00156; Pribosyltran; 1. DR SMART; SM00934; OMPdecase; 1. DR SUPFAM; SSF51366; RibP_bind_barrel; 1. DR TIGRFAMs; TIGR00336; PyrE; 1. DR TIGRFAMs; TIGR01740; PyrF; 1. DR PROSITE; PS00156; OMPDECASE; 1. PE 2: Evidence at transcript level; KW Transferase. SQ SEQUENCE 480 AA; 52277 MW; 2DF6CC127054018C CRC64; MAVARAALGP LVTGLYDVQA FKFGDFVLKS GLSSPIYIDL RGIVSRPRLL SQVADILFQT AQNAGISFDT VCGVPYTALP LATVICSTNQ IPMLIRRKET KDYGTKRLVE GTINPGETCL IIEDVVTSGS SVLETVEVLQ KEGLKVTDAI VLLDREQGGK DKLQAHGIRL HSVCTLSKML EILEQQKKVD AETVGRVKRF IQENVFVAAN HNASPLSIKE APKELSFGAR AELPRIHPVA SKLLRLMQKK ETNLCLSADV SLARELLQLA DALGPSICML KTHVEILNDF TLDVMKELIT LAKCHEFLIF EDRKFADIGN TVKKQYEGGI FKIASWADLV NAHVVPGSGV VKGLQEVGLP LHRGCLLIAE MSSTGSLATG DYTRAAVRMA EEHSEFVVGF ISGSRVSMKP EFLHLTPGVQ LEAGGDNLGQ QYNSPQEVIG KRGSDIIIVG RGIISAADRL EAAEMYRKAA WEAYLNRLGV //